Cephalosporin is an antimicrobial agent that destroys infections caused by bacteria, especially respiratory ones. Administered orally, this second-generation cephalosporin impairs cell wall synthesis in bacteria weakening them, rupturing their membrane, and eventually killing the bacteria.

This oral antibiotic is used to treat common diseases such as bronchitis, sinusitis, and otitis media among others. A study revealed the bioavailability rates of cefprozil as high as 95% when given orally can attain peak plasma levels in 1.5 hours of administration, making it a fast-acting antibiotic.

How Does Cefprozil Work?

Cefprozil acts by attaching to penicillin-binding proteins, inhibiting peptidoglycan crosslinking in the cell wall. This damages their wall structure and kills the bacteria. Among these infections, Cefprozil is useful as an antibacterial capable of combating resistance to even more developed cases.

This medication is usually administered once or twice daily for a specified period, ranging from 10 days in general. The dosage should be completed and taken following the physician’s direction to prevent resistance.

Cefprozil Precautions and Warnings

There are several essential cautionary notes and warnings that you should heed before taking the antibiotic Cefprozil. Some include:

  • Urine Glucose Testing: Cefprozil interferes with urine glucose testing and may cause false positives. Notify the lab before taking a test.
  • Infants: Not recommended for infants 6 months and younger with ear infections or sinusitis. Also, Cefprozil doesn’t cover children under two years for throat and skin abscesses since such safety efficacy has yet to be established.
  • Pregnant and Breastfeeding Women: Be careful and consult with your doctor first before using this antibiotic because Cefprozil excretes into milk when breastfeeding. Similarly, safety has not been established for pregnant women.
  • Alters Urine Ketone Tests: Cefprozil may cause false positives for people with diabetes (due to diabetic medication) during urine ketone tests; the liquid version of this antibiotic contains phenylalanine (which is harmful to Phenylketonuria).

Cefprozil Side Effects

One data found Cefprozil to have comparable efficacy to amoxicillin/clavulanate for treating acute otitis media—however, with significantly fewer side effects—especially gastrointestinal issues. However, you should still consult your provider about potential reactions.

Common Side Effects

  • Gastrointestinal issues like nausea, vomiting, and diarrhea.
  • Leukopenia (reduced white blood cell count)
  • Vaginal yeast infections

Serious Side Effects

While rare, serious side effects requiring medical attention can occur. These include severe or persistent diarrhea, allergic reactions indicated by rash, and abnormal lab results like increased thrombocyte or eosinophil counts.

Other serious side effects include:

  • Unusual Weight Loss
  • Feeling of discomfort
  • Shortness of breath
  • Swollen lymph glands
  • Tightness in the chest
  • Unpleasant breath odor
  • Muscle aches
  • Pain
  • Pinpoint red spots on the skin
  • Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • Rash
  • Vomiting of blood
  • Watery or bloody diarrhea
  • Wheezing
  • Yellow eyes or skin
  • Red skin lesions, often with a purple center
  • Red, irritated eyes
  • Headache
  • Large hives
  • Dark urine
  • Diarrhea, watery and severe, which may also be bloody
  • Difficulty with swallowing
  • Dizziness
  • Fast heartbeat
  • Abdominal or stomach cramps, pain, or tenderness
  • Bleeding gums
  • Blistering, peeling, or loosening of the skin
  • Increased thirst
  • Inflammation of the joints
  • Itching
  • Joint or muscle pain
  • Bloating
  • Blood in the urine or stools
  • Clay-colored stools


More seriously, Cefprozil may result in:

  • Diarrhea
  • Liver damage or failure
  • Kidney problems
  • Allergic reactions
  • Drowsiness, dizziness, or seizures in some individuals

Cefprozil Drug Interactions

Some medications interact with Cefprozil, altering its effectiveness or causing other side effects. As such, you need to let your doctor know about any additional medications you are currently taking like vitamins, over-the-counter medicines, and herbal remedies.

There are specific drugs that are usually not recommended for concurrent usage with Cefprozil, including:

  • Drospirenone (found in Yaz)
  • Norethindrone
  • Norgestimate
  • Norgestrel
  • Cholera vaccines, Live
  • Various hormonal birth control methods containing desogestrel
  • Dienogest
  • Estradiol (such as Vagifem)
  • Ethinyl estradiol
  • Ethynodiol
  • Gestodene
  • Levonorgestrel
  • Mestranol
  • Nomegestrol
  • Cefprozil
  • Anticoagulants (blood thinners)
  • Probenecid or oral contraceptives.

Alcohol, tobacco, and certain foods could also interact with Cefprozil. You should, therefore, discuss your Cefprozil usage recommendations related to diet, drinking, or smoking with your healthcare professional.

While Cefprozil cannot be taken with certain drugs, a combined regimen could, however, still be optimal depending on a patient’s condition. If prescribed together, the doctor or pharmacist may adjust the dosage or frequency of either medication for efficacy and to prevent severe side effects.

How to Use Cefprozil Suspension

Cefprozil suspension is an oral medication, which can be taken once or twice a day. Shake the bottle well before usage to allow uniform mixing of the medicine. You can then measure the dose with a syringe, spoon, or dropper provided and administer it appropriately.

Children should be dosed by weight and you must ensure you balance out your doses so that the amount of drug is continuously achieved. You may take Cefprozil with or without food. Taking it with food might help lessen aggression to the stomach.

Common symptoms of infection may subside after a few days of taking antibiotics. However, it does not mean the issue is resolved. Follow the entire course as recommended by your physician to prevent a new bout of infection.

Cefprozil Strengths and Dosages

Cefprozil comes in two forms; oral tablets and powder for suspension. These forms enable dosage flexibility across different strengths suitable for varying patients.

Formulation Strengths Typical Adult Dose Typical Children’s Dose
Tablets 250 mg, 500 mg 250-500 mg every 12-24 hours Not recommended
Powder for Oral Suspension 125 mg/5 mL, 250 mg/5 mL 250-500 mg every 12 hours 7.5-20 mg/kg every 12-24 hours


Table 1 summarizes the currently available Cefprozil strengths and common dosage recommendations.

  • For adults and individuals older than thirteen years the drug is available in tablets of 250-500mg. The tablets are administered every 12 to 24 hours for about a week, depending on how severe the illness is.
  • Dosages for children between 6 months to 12 years of age are generally weight-based, with 7.5–15 mg/kg every 12 hours or a complete dose of about 20mg/kg once in day.

Cefprozil is accessible in different formulations and strengths to allow for customized dosage regimens per patient’s age, weight, kidney function, and infection profile. Still, close provider supervision is needed to determine optimal personal dosage.

Cost of Cefprozil in America

The average retail price for the most commonly prescribed version of Cefprozil oral suspension is $124.60 for 50 mL. However, patients can obtain it for way less if they qualify for coupons and discounts.

Drug Formulation Quantity Estimated Cost
Cefprozil 250 mg/5 mL oral suspension 50 mL $20.90
Augmentin 125 mg-31.25 mg/5 mL oral suspension 100 mL $642.04
Amoxicillin 500 mg oral capsule 4 capsules $9.93

The table above shows a cost comparison between Cefprozil and two alternative antibiotics

  • Augmentin is substantially more expensive than Amoxicillin which provides a lower-cost alternative.
  • All three drugs are commonly prescribed antibiotics to treat bacterial infections. However, their drug class and approval differ.

FAQ for Cefprozil

Can I take food with Cefprozil?

Cefprozil can be taken with food or milk. Taking the medication with food helps to prevent stomach upset as is common when a patient is on antibiotics.

What should I do if I miss a dose?

If you’ve missed taking a dose of Cefprozil, take it as soon as you remember. Nevertheless, skip doses if they fall close to the next administration time and continue with the regular dose.

How should Cefprozil be stored?

Cefprozil should be kept at room temperature, away from light and moisture. Also, ensure that all medications are kept away from children’s reach, as well as out of pets’ reach. The suspension liquid should be thrown when 14 days are over regardless of what is left inside.

Does Cefprozil cure viral infections?

No. This drug does not cure any of the viral infections be it flu or colds, although it can treat bacterial ones.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

Product was successfully added to your cart!