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Trulance (Plecanatide)
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This medication is a brand name for the active ingredient plecanatide. Trulance is a prescription medication that is used to treat patients with IBS-C, or irritable bowel syndrome with constipation. It is also used to treat constipation that doesn’t go away and has no obvious cause, or chronic idiopathic constipation.
Trulance treats these conditions by causing specific substances in the intestines to become active. These substances can help to create more secretion of fluids as well as increase muscle movement. This can help people to have bowel movements who had trouble with them before. It changes the stools’ consistency so that they are easier to pass. It can also help with stomach pain, bloating, and other bowel movement changes.
This medication is classified as a guanylate cyclase-C agonist or GC-C agonist. The protein GC-C works inside the intestines and brings fluid to them. This can help speed up how fast food moves through your system. This can relieve stomach pain and soften stools so that patients are able to have bowel movements regularly.
Labeled Warnings of Trulance
There is a boxed warning for this medication which is the most serious type of medication warning. It warns that patients under the age of six shouldn’t take this medication because of a great risk of serious dehydration. This risk is also present for children who are aged six to 18. For this reason, Trulance isn’t recommended for use in children, and it’s not approved for children.
In animal trials, it was found that this medication caused young animals to have serious dehydration. The dehydration is generally caused by persistent diarrhea.
Precautions and Warnings for Trulance
Don’t use this medication if you’re allergic to it. Patients who have a bowel obstruction shouldn’t take Trulance. This is a blockage in either the small or large intestines.
This medication can cause severe diarrhea in some patients. When this happens, it can lead to serious dehydration that can be severe and even fatal. If you take this medication and get dizzy, suddenly have stomach pain, or you experience serious diarrhea, you may need immediate medical help. While you take this medication, be sure to drink a lot of fluids to prevent dehydration.
If you’re pregnant, there may be a risk to your baby if you take this medication. While no harm was found in animal trials of pregnant animals, it isn’t known whether human babies could face risks. If you’re breastfeeding, it might be safe for you to use this medication. But, it’s unknown whether Trulance ends up in breast milk. Talk to your doctor about whether you should take Trulance while nursing an infant.
It’s unknown whether it’s safe to keep taking birth control while taking Trulance. Talk to your doctor about any possible risk and whether you need to use other forms of birth control. Before you have any type of surgery while on this medication, make sure the doctor knows that you take it.
Side Effects of Trulance
While many patients don’t have any side effects from Trulance, there are some possible side effects.
Mild Side Effects
Patients who experience these side effects often have them go away after a couple of weeks. If they get worse or bother you, talk to your doctor about them. Some of the milder side effects possible include:
- Nausea
- Abdominal tenderness or bloating
- Mild diarrhea – loose stools with cramps, bloating, or abdominal pain
- Developing infections like a UTI or a cold
- Dizziness
Serious Side Effects
Some of the more serious side effects that patients can experience include:
- Allergic reactions such as developing an itchy rash, swelling in the face or in the mouth, dizziness, or trouble breathing
- Serious diarrhea that can cause dehydration
Strengths and Dosages of Trulance
Trulance is only available as a 3 mg tablet. It’s generally prescribed to be taken once per day. A Trulance tablet can be crushed and put into applesauce for those who have a hard time swallowing pills. It can also be crushed and fed into a GI tube. The dosage is typically the same in every patient who takes this medication for constipation or Crohn’s disease with constipation.
| Trulance tablets: | 3 mg |
Cost of Trulance in America
The exact price that a patient pays in the U.S. for Trulance depends on the specific pharmacy that they go to. In general, the price is about $675 for a 30-day supply of tablets. There is no generic yet for this medication, and that keeps the price of the brand-name drug Trulance expensive.
Trulance Alternatives
There are many laxatives and stool softeners that are available on the market. These include bisacodyl, sold over the counter as Dulcolax, and lactulose, also known as Generlac. There is also polyethylene glycol 3350, sold OTC as MiraLAX, and senna, sold under the brand name Senokot. Linzess, or linaclotide, is another possible alternative that is available by prescription.
FAQs of Trulance
What does Trulance treat?
It is used to treat irritable bowel syndrome with constipation or frequent constipation that doesn’t have an obvious cause.
What forms does Trulance come in?
It’s only available in a 3 mg tablet. It can be crushed if necessary so that it can be taken more easily by those with problems with pill swallowing.
Why is Trulance so expensive?
Trulance is a brand-name medication with no generic equivalent, so the price can be kept high by the pharmaceutical company because of the lack of competition.
Which company manufactures Trulance?
The manufacturer is Salix Pharmaceuticals.
Can Trulance be used to treat occasional constipation?
It’s generally used for chronic constipation. The occasional bout of constipation can usually be treated with an OTC laxative or stool softener.
Can Trulance be used in children?
No, it does not have approval for those under 18, and it isn’t suggested for them to take it. It can cause severe dehydration in kids and adolescents.
What is the active ingredient in Trulance?
The active ingredient is plecanatide.
How does Trulance work to treat constipation?
Trulance is a GC-C agonist, working with this protein to cause more fluid to be drawn to the intestines. This helps food to move through the intestines more quickly and allows stools to be softer and easier to pass.
When was Trulance FDA-approved?
It was first approved by the FDA in 2017.
How often do patients take Trulance?
It’s generally taken once a day, every day to keep stools passing more easily.
Is Trulance the same thing as Linzess?
Both of these drugs are classified as GC-C agonists, but they each contain different ingredients and work in different ways. Trulance is newer than Linzess.
Do you have to take Trulance with food?
You can take it with food or without it
Our Guarantee For Buying Trulance From A Canadian Pharmacy Partner
At MyRx Outlet, we are committed to delivering safe, high-quality medications that you can trust. We adhere to strict regulations in every country we operate in, ensuring that your order is handled by a licensed Canadian pharmacy or a trusted partner overseas. Each medication has been legally approved by Health Canada or other respected authorities. To purchase Trulance at a discounted rate, call 1-888-551-2467.
IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.
