Creon is a prescription medication that contains a combination of three enzymes: lipase, protease, and amylase. Lipase helps break down fats into fatty acids and glycerol, protease aids in protein digestion, and amylase facilitates the breakdown of carbohydrates into simple sugars. These enzymes are vital for proper digestion and absorption of nutrients from the food we consume.

Pancreatic insufficiency is a condition in which the pancreas does not produce enough enzymes to properly digest food. This deficiency leads to malabsorption and various gastrointestinal symptoms, such as steatorrhea (fatty stools), weight loss, and nutritional deficiencies. Creon is primarily prescribed for individuals with pancreatic insufficiency to supplement the lacking enzymes and improve nutrient absorption.

The most common people to use this medication are patients with cystic fibrosis, chronic pancreatitis patients, post pancreatic surgery patients, pancreatic cancer patients, and patients with other digestive disorders

Warnings and Precautions

While Creon is an effective treatment option, it is crucial to understand the potential risks and take necessary precautions to ensure safe usage.

  1. Consult Your Healthcare Provider: Before starting Creon treatment, always consult your healthcare provider. They will assess your medical history, current medications, and health condition to determine the appropriate dosage and usage instructions.
  2. Allergies and Sensitivities: Inform your doctor about any allergies or sensitivities you may have, especially to pork products or pancreatic enzymes. Creon is derived from pig pancreas, and allergic reactions may occur.
  3. Dosage Adjustment: Never change the prescribed dosage of Creon without your doctor’s approval. Dosage adjustments should only be made under medical supervision.
  4. Pediatric Use: If administering Creon to a child, ensure you follow your pediatrician’s instructions carefully. Dosage for children may differ from that of adults.
  5. Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Creon with your doctor. They will determine whether it is safe for you and your baby.
  6. Drug Interactions: Inform your doctor about all the medications, supplements, and herbal products you are taking. Some drugs may interact with Creon, affecting its efficacy.
  7. Acute Pancreatitis: Creon is not indicated for the treatment of acute pancreatitis. If you have a sudden episode of pancreatitis, seek immediate medical attention.
  8. Gout: Creon may increase uric acid levels in the blood, potentially worsening gout. Inform your doctor if you have a history of gout.
  9. High Blood Uric Acid Levels: Individuals with high blood uric acid levels (hyperuricemia) should use Creon with caution.
  10. Diabetes: Creon may affect blood glucose levels. Diabetic patients should monitor their blood sugar closely while taking this medication.
  11. Gastrointestinal Disorders: Use Creon with caution if you have a history of gastrointestinal obstruction or other significant gastrointestinal disorders.
  12. Liver or Kidney Impairment: If you have liver or kidney impairment, your doctor will carefully assess whether Creon is suitable for you.
  13. Respiratory Disorders: Creon can be inhaled accidentally and may cause respiratory irritation. Be cautious during handling.
  14. Pancreatic Insufficiency in Cystic Fibrosis: Creon is commonly used to treat pancreatic insufficiency in cystic fibrosis patients. Follow your doctor’s instructions carefully.
  15. Intestinal Obstruction: Creon is not recommended for individuals with intestinal obstruction.
  16. Swallowing Difficulties: If you have trouble swallowing capsules, consult your doctor for alternative administration methods.
  17. Storage and Handling: Store Creon in a cool, dry place away from moisture and heat. Keep it out of reach of children and pets.
  18. Expired Medication: Do not use Creon beyond its expiration date.
  19. Adverse Effects: Be vigilant about any adverse effects while using Creon, and report them to your doctor promptly.

Side Effects

While it is generally well-tolerated, like any medication, it may lead to side effects in some patients.

Common Side Effects of Creon

  1. Abdominal Discomfort: One of the most common side effects reported with Creon usage is mild abdominal discomfort, including bloating and gas. These symptoms usually resolve with continued use as the body adjusts to the medication.
  2. Diarrhea: Some patients may experience loose stools or diarrhea, especially during the initial phase of treatment. If this persists, consulting a healthcare professional is essential.
  3. Nausea: In certain cases, Creon may cause mild nausea, particularly when taken on an empty stomach. Taking the medication with meals can help reduce this effect.
  4. Headache: While rare, some individuals might experience headaches while taking Creon. If headaches become severe or persistent, medical advice should be sought.

Rare Side Effects of Creon

  1. Allergic Reactions: Although uncommon, some individuals may develop allergic reactions to Creon, characterized by itching, rash, hives, or difficulty breathing. Any signs of an allergic reaction warrant immediate medical attention.
  2. Constipation: While Creon more commonly causes diarrhea, it can also lead to constipation in some patients. Maintaining adequate hydration and adjusting the dosage under medical supervision can help manage this side effect.
  3. Vomiting: Rarely, Creon usage may result in vomiting. If this occurs frequently or becomes severe, a healthcare provider should be notified.
  4. Increased Blood Uric Acid: In isolated cases, Creon may elevate blood uric acid levels, which could be a concern for individuals with a history of gout.

Severe Side Effects of Creon

  1. Severe Allergic Reactions: Although rare, severe allergic reactions to Creon can occur, leading to anaphylaxis. This life-threatening condition requires immediate emergency medical attention.
  2. High Blood Sugar (Hyperglycemia): In some cases, Creon may cause elevated blood sugar levels. Diabetic patients should closely monitor their blood glucose levels and inform their healthcare provider if any abnormalities arise.
  3. Fibrosing Colonopathy: A very rare but serious side effect, fibrosing colonopathy is associated with high doses of pancreatic enzyme replacement therapy (PERT) like Creon. It results in the thickening of the colon wall and may lead to intestinal blockages.
  4. Gastrointestinal Obstruction: Rarely, Creon can cause gastrointestinal obstruction due to the formation of concretions. Symptoms may include severe abdominal pain, bloating, and vomiting.
  5. Hypersensitivity Pneumonitis: This is an extremely rare side effect of Creon, characterized by inflammation of the lung tissue. It requires immediate medical intervention.
  6. Rectal Bleeding: In isolated cases, Creon usage has been associated with rectal bleeding. If this occurs, a healthcare provider should be consulted promptly.


While Creon is generally safe and effective, it’s crucial to understand its interactions with other medications, herbs, and foods to ensure optimal results and avoid potential adverse effects.

Drug Interactions with Creon

  1. Proton Pump Inhibitors (PPIs): PPIs, often used to treat acid reflux and peptic ulcers, can reduce stomach acid. Since stomach acid is essential for activating Creon, taking PPIs simultaneously may hinder its efficacy. It’s advisable to take PPIs at least two hours apart from Creon.
  2. H2 Blockers: H2 blockers, another type of acid-reducing medication, may also interfere with Creon’s activation. Similar to PPIs, it’s best to separate the dosages of H2 blockers and Creon by a few hours.
  3. Antacids: Antacids neutralize stomach acid, which can impact Creon’s function. It’s recommended to avoid taking antacids at the same time as Creon. If needed, take them a few hours apart.
  4. Iron Supplements: Iron supplements may reduce the absorption of lipase, an essential enzyme in Creon. If you take iron supplements, discuss the timing with your healthcare provider to avoid any conflicts.
  5. Orlistat (Alli): Orlistat is a weight-loss medication that reduces fat absorption in the intestine. Taking it concurrently with Creon may decrease the effectiveness of both medications.

Herbal Interactions with Creon

  1. St. John’s Wort: This popular herbal supplement used to treat depression and anxiety can increase the production of certain enzymes in the liver. These enzymes may break down Creon more quickly, reducing its efficacy.
  2. Ginseng: Ginseng is known for its potential to lower blood sugar levels. When taken with Creon, it may lead to unpredictable changes in blood sugar levels, particularly in individuals with diabetes.
  3. Echinacea: Echinacea is often used to boost the immune system, but it may interfere with certain enzymes in Creon, affecting its overall effectiveness.
  4. Garlic: Garlic is another herb that may influence the activity of enzymes in Creon, potentially reducing its effectiveness in aiding digestion.

Food Interactions with Creon

  1. High-Fat Foods: Creon is specifically designed to aid in the digestion of fats. Consuming high-fat meals while taking Creon can help the medication work effectively. However, avoid extremely high-fat meals as they may overwhelm the enzymes in Creon.
  2. Grapefruit and Grapefruit Juice: Grapefruit and its juice can interact with enzymes in the small intestine and potentially affect the absorption of certain medications, including Creon. It’s best to avoid grapefruit products while on Creon.
  3. Alcohol: While alcohol does not directly interact with Creon, it can worsen some conditions that require Creon therapy, such as chronic pancreatitis. Limiting alcohol intake is advisable if you’re on Creon.
  4. Spicy Foods: Spicy foods may exacerbate gastrointestinal symptoms in some individuals. If you experience discomfort, discuss dietary modifications with your healthcare provider.


To ensure its effectiveness and safety, understanding the dosing guidelines for Creon is crucial.

Initial Dosing of Creon

The initial dosage of Creon is determined by a healthcare provider based on several factors, such as the patient’s age, weight, and the severity of their pancreatic enzyme deficiency. Generally, the initial dose for adults is higher than that for children. The goal of the initial dosing is to address the immediate need for enzyme replacement and stabilize the patient’s condition.

Maintenance Dosage for Creon

Once the initial dosing phase is completed, the maintenance dosage of Creon is established. Maintenance doses are often lower than the initial doses and are intended to provide continuous support for proper digestion. Healthcare professionals adjust maintenance dosages as needed, depending on the patient’s response to the treatment and any changes in their medical condition.

Missed Dose of Creon

If a dose of Creon is missed, the patient should take the missed dose as soon as they remember, unless it is almost time for the next scheduled dose. In such cases, patients should skip the missed dose and continue with the regular dosing schedule. It is important not to take double doses to make up for the missed one.

Overdose of Creon – What to Do?

In the rare event of a Creon overdose, it is crucial to seek immediate medical attention. Overdose symptoms may include abdominal pain, bloating, or diarrhea. Prompt medical intervention can help manage any adverse effects and prevent complications.


To ensure its effectiveness and potency, proper storage is essential.

  1. Temperature: Store Creon at room temperature, ideally between 68°F and 77°F (20°C and 25°C).
  2. Avoid Moisture: Keep the medication away from excessive moisture and humidity.
  3. Protect from Light: Store Creon in its original container, protecting it from direct sunlight.
  4. Keep Out of Reach: Store the medication out of the reach of children and pets.
  5. Medication Expiry Date: Always check the expiry date and discard any expired medication promptly.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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