What Is A Generic?×
A generic drug is essentially a copycat version of a brand-name medication, offering the same safety, quality, and effectiveness, but often at a lower cost. When a brand-name drug's patent expires, other companies can produce the generic version. These generics contain the same active ingredients and work in the same way in the body as the original brand-name drug. However, they might differ in color, shape, or inactive ingredients. The appeal of generic drugs lies in their affordability; they provide a more cost-effective option for consumers without sacrificing the benefits of the original medication. This makes healthcare more accessible to a larger portion of the population, ensuring that more people can receive the treatment they need without the burden of high costs associated with brand-name drugs.
Jardiance is the brand name of the generic drug empagliflozin. The drug belongs to a class of drugs known as sodium-glucose cotransporter 2 (SGLT2) inhibitors. SGLT2s are FDA-approved for use in combination with dieting and exercising to lower blood sugar levels in adults suffering from type 2 diabetes.
Type 2 diabetes affects almost 30 million Americans and it accounts for around 95% of all diabetes cases. Jardiance has helped many people struggling with type 2 diabetes. This drug is used to manage type 2 diabetes, heart failure, and cardiovascular complications.
You should note that Jardiance isn’t FDA-approved for use among type 1 diabetes patients. Consult your doctor for the appropriate medication, if you’re suffering from type 1 diabetes.
Besides type 2 diabetes, Jardiance also helps to control the following;
- The risk of cardiovascular complications, like stroke, among type 2 diabetes patients.
- Reduce the chances of death or hospitalization due to heart failure, among type 2 diabetes patients.
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How Does It Work?
Jardiance (empagliflozin) works by utilizing its SGLT2 inhibition characteristics. SGLT2 proteins are found in the kidneys and they function by absorbing glucose into the blood, causing a blood glucose spike. Jardiance blocks this process by binding with the SGLT2 proteins increasing glucose levels found in your urine.
Clinical trials have found an increase in glucose levels of approximately 64 grams and 78 grams daily in the urine of type 2 diabetes patients when using Jardiance 10 mg and 25 mg respectively.
Jardiance also reduces the amount of salt (sodium) your kidney can reabsorb back into your blood. This is effective in reducing blood vessel strain and curbing heart-related complications.
This drug can also help you to achieve your weight management ambitions safely with minimal risk of heart attacks. It works in combination with other medication, exercise, and diet to decrease your blood pressure without increasing your heart rate.
How Long Does it Take to Work?
Clinical trials lasting 24 weeks have shown significant reductions in blood glucose levels, fasting plasma glucose levels, and body weight in patients using the 10 mg and 25 mg daily doses of empagliflozin.
The results include a 7% drop in A1C (blood glucose) levels among the following;
- 35% of patients taking the 10 mg Jardiance tablet
- 44% of patients taking the 25 mg Jardiance tablet
- 12% of patients in the inactive placebo group
Moreover, the fasting glucose levels dropped by 19 and 25 points (mg/dL) for patients taking the 10 mg and 25 mg tablets respectively. Patients in the placebo group dropped their fasting glucose levels by 12 points.
In the 24-week-long study, the results for weight loss include the following;
- 8% weight loss from the baseline weight of the 10 mg empagliflozin dose
- 2% weight loss from the initial weight of the 25 mg empagliflozin dose
- 4% weight loss in the placebo group
Are there Generics?
There isn’t a generic version of empagliflozin, apart from Jardiance. However, you might find online pharmacies claiming to offer other generic versions of empagliflozin. Be wary not to entrust your health to such crooks as the drugs are unsafe for you, and their results might be catastrophic.
Remember that Jardiance is a prescription drug. It can’t be bought or refilled without a valid prescription form from your doctor.
What Forms Does it Work?
Jardiance is only available as a 10 mg and 25 mg empagliflozin pill. Both tablets are pale yellow with a biconvex shape. The drugs are always film-coated with the Boehringer Ingelheim’s company logo on either side.
You can tell the difference between the two tablets by checking for their debossed symbols. The debossed character for the 10 mg and 25 mg pills is S 10 and S 25, respectively.
Precautions and Warnings
As much as medication should work in your best interest, there’s a chance that it’ll present an opportunity for other conditions to manifest when not used correctly. You need to be cautious to avoid such conditions.
Some of the precautions and warnings that come with its use include the following;
- Although diabetic ketoacidosis (DKA) is common among type 1 diabetic patients, type 2 diabetes patients can also experience it. DKA can happen even when your blood glucose levels are below 250 mg/dL. This is a fatal condition whereby your liver breaks down fat to form energy; the byproducts are ketons- an acid. Always replace your lost fluids and electrolytes to prevent suffering from DKA.
- Patients with type 2 diabetes and an eGFR of <30 ml/min/1.73 m2 shouldn’t use Jardiance for glycemic control as it’s ineffective.
- You should stop using Jardiance for almost four days before surgery.
- Jardiance should not be used by patients who have impaired renal function, the elderly, or patients on diuretics, as it might lead to volume depletion. This condition is treatable by adding intravenous fluids or blood to your bloodstream.
- The use of Jardiance with insulin or insulin secretagogues, like sulfonylurea, increases your chances of suffering from hypoglycemia.
- Patients suffering from vaginal, or penis infections will likely get severe urinary tract infections when they use Jardiance.
- Consult your healthcare team on using Jardiance if you’ve got liver or kidney problems.
- Jardiance may result in low blood pressure. Consult your doctor if you’ve got a history of low blood pressure on how to use the medication.
Jardiance is a prescription drug that has a few side effects. If your doctor prescribes this drug, they believe its benefits outweigh the side effects. Most of these side effects occur and disappear quickly while others are serious and may require medical intervention.
Common Side Effects
Common side effects of using Jardiance include the following;
- Frequent urination
- Urinary tract infection
- Yeast infections
Severe Side Effects
More serious side effects of Jardiance are listed below;
- Kidney injury
- Severe allergic reactions
- Increased cholesterol levels
- Serious genital yeast infections
- Orthostatic hypotension, whereby your blood pressure drops when you quickly stand up from a sitting position.
Drug interactions with empagliflozin can enhance or reduce its effectiveness and also affect its safety. The following is how it interacts with other drugs;
Diuretics with empagliflozin enhance your chances of volume depletion, significantly if you’ve impaired renal function. So, always check your volume status and renal function before using Jardiance with diuretics.
Insulin or Insulin Secretagogues
Administer a low dose of insulin or insulin secretagogues to reduce the risk of hypoglycemia.
The administration of Jardiance alongside lithium may result in low serum lithium concentrations. This causes low fertility, mood swings, and depression. Check your lithium concentrations before initializing your Jardiance dose and in between doses.
Strengths and Dosages
Jardiance is an oral medication dosed once daily, preferably in the morning. It consists of two doses, namely;
- The 10 mg tablet
- The 25 mg tablet
Your doctor will determine your daily dose depending on the severity of your condition and medical history.
Cost of Jardiance
The cost of Jardiance varies significantly based on your prescription plan, insurance cover, and type of pharmacy. However, if you have no insurance or any other financial assistance, expect to pay the full retail price of $570.48 for a month’s supply.
Yes! Alternative medication of Jardiance includes the following;
IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.