Pregnyl is a hormone that is administered to treat reproduction and hormonal imbalances among men, women, and young boys.

It is also known as Human Chorionic Gonadotropin (HCG). It is classified as a synthetic hormone and is administered to help women get pregnant. The medicine matures the eggs and triggers their release during the ovulation process.

It helps men maintain their testosterone levels and enhance fertility by mimicking the functions of Luteinizing Hormone (LH), which balances hormonal levels. HCG also treats young boys whose testicles have not descended naturally into the scrotum.

Pregnyl can be injected either by yourself into the muscle, following proper training from your doctor, or by a healthcare professional during an appointment. A healthcare professional will prescribe Pregnyl products if you are diagnosed with prepubertal cryptorchidism because of an anatomical obstruction. It can also be prescribed if you are diagnosed with hypogonadotropic hypogonadism secondary to a pituitary deficiency in males.

However, Pregnyl is not approved for treating conditions and symptoms like

  • Obesity
  • Fatigue
  • Weight loss
  • Erectile or sexual dysfunction
  • Performance enhancement
  • Anti-aging
  • Chronic pain management.

Warnings and Precautions with Pregnyl

Pregnyl is not recommended for breastfeeding women. Studies suggest the medication may pass into breast milk, potentially affecting the infant. It is advised to avoid using Pregnyl if it is past the expiration date, the package is torn, or there are signs of tampering.

You need to inform your doctor and pharmacist about your drugs and health problems before consumption. You must ensure that Pregnyl is safe for use. You should not start, stop, or change the dose of any medicine without consulting with your physician.

A patient should take precautions before using Pregnyl if they:

  • Are allergic to human gonadotropins.
  • They have cancer or tumors in the ovary, breast, or uterus in females.
  • Have prostate or breast carcinoma in males.
  • Have malformations of the reproductive organs.
  • Fibroids in the uterus
  • Heavy or irregular vaginal bleeding
  • Menstrual bleeding.

Pregnyl Side Effects

Pregnyl has some side effects, which are as follows:

Common Side Effects

Serious Side Effects


Mood Swings

Facial hair growth


Pain, irritation, or inflammation at the injection site


Abdominal issues

Allergic reactions (rashes, itching or hives, swelling of the face, lips, or tongue)

Respiratory problems

Breast enlargement

Penis and testes enlargement

Nausea and vomiting

Bloating or pelvic pain

Increase in height

Sudden weight gain

Trouble passing urine or change in its amount

Fluid build-up around the lungs or stomach

Cough with foamy mucus

Rapid heartbeats

Signs of a blood clot

Numbness or weakness on one side of the body

Chest pain

Audio and vision impairment

Pain or swelling in one leg

Early puberty in boys

Common side effects of Pregnyl may occur, but it’s essential to inform your doctor regardless. However, seek immediate medical attention if you experience serious side effects.

Females are at risk of developing a rare yet serious disease called Ovarian Hyper-Stimulation Syndrome (OHSS) when taking Pregnyl. The condition occurs when abnormal follicles and ovaries are overstimulated. It is a life-threatening condition and requires immediate medical attention.

Pregnyl should be used according to the doctor’s instructions and guidance. A healthcare expert monitors you via ovarian ultrasound and checks your hormonal level.

Drug Interactions with Pregnyl

Pregnyl interacts with Gonadorelin. It releases a hormone called gonadotropin, which treats fertility problems in men and women. It is effective in treating amenorrhea and hypogonadism. Its chemical structure resembles that of its chemical. This medication is administered by injecting it into a blood vessel like Pregnyl.

They are also available as a nasal spray. However, the medication can have an effect on specific lab tests (including luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels and cause false test results.

The doctors and lab personnel should be informed of all the products (prescription and nonprescription drugs and herbal products) the patient uses for proper treatment and diagnosis. This is important because it could increase the risks of serious side effects.

Pregnyl Alternatives

It is recommended to seek the approval of a doctor or a healthcare professional before you start taking the above medicines. These are called “urinary-derived human products” in the medical field with no difference between them.

Ovidrel is produced with a “genetic recombinant technology.”It is easy to do since it is packaged in a prepared syringe and needle and causes fewer skin reactions. They are available in a 250-mcg dose which is 5,000 – 6,000 IU of hCG.

Ovidrel is the sole FDA-approved hCG for subcutaneous use. Doctors administer other uHCG products, which have shown outstanding results.

Pregnyl contains human chorionic gonadotropin (hCG). Here are some alternative medications that a doctor might prescribe depending on the specific condition being treated:

Strengths and Dosages of Pregnyl

Pregnyl has to be administered under the supervision of a doctor or a healthcare expert. It is for intramuscular use only for one patient.

Each dosage of Pregnyl depends on the physican’s preference and patient’s age, weight and condition.

If the initial treatment course is not effective, a doctor may recommend another series of injections with a higher dosage (1,000 USP units per injection) after a one-month break.

Here are some examples of Pregnyl dosing:

  • 4000 USP units thrice a week for three weeks.
  • 5000 USP units every second day for four injections.
  • Fifteen injections for 500 to 1000 USP units over six weeks.
  • 500 USP units thrice a week for 4 to 6 weeks.

Pregnyl FAQ

How do I inject Pregnyl?

You should start by cleaning the injection area with an alcohol swab before pinching your skin to create a small fold. Insert the needle at a specific angle. After injecting the medication, you can hold the needle in place for a few seconds before taking it out. Discard the syringe immediately and put it into a Sharps Container after use.

How long does it take for Pregnyl to work?

Pregnyl, which is generally taken three times per week, takes approximately 24 to 36 hours to work.

What is Pregnyl used for in IVF?

Pregnyl causes ovulation and treats infertility and sexual problems among men and women.

Which area to inject Pregnyl in?

Pregnyl is a subcutaneous injection (under your skin) that is injected in the lower abdominal area or thigh.

What size of needle do I need to inject Pregnyl?

You can use a three-cc syringe with a 22-gauge 1.5-inch needle for mixing and drawing up. The length and diameter make injection easier.

How long do Pregnyl side effects last?

There are certain side effects of Pregnyl that may occur but don’t require immediate medical attention. They go away as the body adjusts to the treatment. Your healthcare provider will teach you how to cope with or prevent it.

Why do men take Pregnyl?

Pregnyl is given to men to treat hypogonadism, a condition that causes the body to produce low testosterone. It is also used among young boys whose testicles have not descended into the scrotum naturally.

How do I store Pregnyl?

Pregnyl is used as a trigger or supporting injection in the menstrual cycle. It should be kept in the original package in a cool, dry place below 25°C. It should not be stored in the freezer or used after its expiration date.

Do people take Pregnyl for bodybuilding?

Bodybuilders who consume anabolic steroids such as testosterone use Pregnyl to prevent or reverse the side effects of steroids, such as infertility and gonad shrinkage.

When do you get your period after Pregnyl?

After Pregnyl, expect your period within your usual cycle (around 14 days after ovulation) if you are not pregnant. Pregnancy stops menstruation. Consult your doctor if you have concerns.

How much does Pregnyl cost in America?

The per-unit cost of a Pregnyl injection is between $131.92 and $188.51. However, the prices could vary at different pharmacies.

Why is Pregnyl so expensive?

Pregnyl and other HCG medications are expensive because insurance companies don’t pay for fertility treatments and medication. There have been reports of a hike in fertility medicines prices because of a lack of affordable and generic alternatives.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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