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Pimozide (brand name Orap) is an antipsychotic medication used primarily to reduce some of the most troubling symptoms common to Tourette’s syndrome. Pimozide alters the actions of chemicals in the brain, helping to control vocal outbursts and physical tics that interfere with daily life. It is specifically used to inhibit involuntary physical tics and vocal outbursts. Pimozide is generally effective at reducing the quantity and severity of these symptoms, though it is rarely able to eliminate them completely.
It targets the central nervous system to reduce involuntary movements and vocal outbursts. The drug works to decrease dopaminergic action in the brain. Dopamine is a neurotransmitter that has a strong impact on movement and moods. A reduction in the dopaminergic activity in the brain has been shown to reduce both the frequency and the severity of these troubling symptoms, allowing those living with Tourette’s syndrome to have a more comfortable and rewarding life.
Pimozide’s effectiveness is strongly dose-dependent and can also differ significantly from patient to patient depending, in part, on the individual’s ability to metabolize the drug effectively. Patients must follow their doctor’s instructions carefully to achieve the best results.
This medication is available by prescription and typically comes in tablet form. Pimozide can produce significant side effects making it crucial to carefully review all available literature, and seek information from your medical health provider to ensure that all of your questions are answered before beginning to use pimozide.
Precautions and Warnings of Pimozide
Pimozide can have serious side effects and may interact in undesirable or dangerous ways with many commonly prescribed and over-the-counter medications. Because of the many contraindications, pimozide is not generally prescribed for mild to moderate symptoms that are able to be sufficiently controlled by other medications.
Pimozide is generally contraindicated for pregnant women and may cause physical withdrawal symptoms, including involuntary muscle movement in newborns. Pregnant women should not use pimozide without proper medical advice due to its potential risks.
Pimozide Side Effects
Pimozide can cause serious side effects and should be used with caution under the supervision of a proper medical professional. Pimozide is particularly risky for patients with existing heart conditions, as it may cause changes in heart rhythms, as well as more serious heart conditions.
Dry mouth is the most common side effect reported by patients taking pimozide. Chewing sugarless gum or sucking on sugar-free hard candy can help ease this symptom. Alternatively, ice chips or a saliva substitute may help as well. While this symptom is not life-threatening, if dry mouth persists for longer than 2 weeks patients should seek advice from their doctor or dentist as persistent dry mouth can increase the risk of dental disease.
As with any drug, allergic reactions are possible. Seek medical help immediately if you experience any symptoms of an allergic reaction such as facial swelling, or difficulty breathing.
Common Side Effects
The most common side effects reported by patients taking pimozide include:
- Headache
- Fever
- Drowsiness or dizziness
- Dry mouth
- Blurred vision
- Weakness or lethargy
Rare Side Effects
The following side effects are less common but may be serious and should be reported to a doctor immediately.
- Difficulty breathing
- Swelling of the face, lips, tongue, or throat
- Increase or new involuntary movements
Pimozide Drug Interactions
Care must be taken when using more than one medication. Even the most innocuous of drugs may produce unexpected and potentially dangerous adverse health conditions when taken with another drug. For this reason, it is important to discuss all medications you may use while taking pimozide, including any over-the-counter medications, vitamins, or supplements.
Pimozide is known to produce adverse reactions when combined with many different drugs so it is vital that patients take a careful inventory of all medications they use regularly and discuss each medication with the prescribing doctor before starting the first dose of pimozide.
Some types of drugs are known to cause more severe drug interactions when combined with pimozide and medications in any of these “high-risk” categories should only be used under the express instruction of your doctor.
Drug categories with a high risk of potential adverse interaction with Pimozide:
- Allergy & Cold Medications: Most allergy & cold meds contain central nervous system (CNS) suppressants which can lead to serious oversedation and respiratory suppression when combined with pimozide. Alcohol, motion sickness, and sleeping pills are CNS suppressants as well
- Antidepressants: Common selective serotonin reuptake inhibitors (SSRIs) like sertraline and paroxetine can also lead to dangerous oversedation when taken with pimozide
- Antiarrhythmic drugs: Medications like sotalol and disopyramide can disrupt heart function when taken with pimozide.
- Certain Antifungals & Antibiotics: Clarithromycin, fluvoxamine, and fluoroquinolones like ciprofloxacin, enoxacin, and norfloxacin may increase the risk of serious heart conditions
Pimozide is available in an oral tablet form and sold in either 1mg or 2mg strengths. Dosages will vary depending on several factors including the age of the patient, the severity of the symptoms, the patient’s current and past medical history, and more. Your doctor will determine the correct dosing schedule for your specific needs.
| Patient Age | Initial Dose | Maximum Dose |
| Adult | 1 to 2 mg total per day, taken in multiple doses | Generally not more than 10 mg per day |
| Children (12 years old and older) | 0.05 mg per kg of body weight given orally at bedtime | Dependent on age & weight; 0.2 mg per kg per day, not to exceed 10 mg per day |
Pimozide dosages have a high degree of variability and your doctor will likely increase the dose gradually. It is important to follow your doctor’s instructions carefully. Do not stop taking pimozide abruptly without speaking with your doctor first as you will likely need to stop taking the drug gradually as well.
Cost of Pimozide in the USA
Pimozide prices can vary significantly depending on the patient’s location, the pharmacy they choose, their health insurance coverage, and their use of pharmacy coupons and discount programs.
| Strength | Per Tablet Price | Price Per Bottle of 100 Tablets |
| 1 mg | Up to $1.65 | Up to $165 |
| 2 mg | Up to $2.17 | Up to $217 |
For patients using Medicare to cover prescription costs, pimozide is covered on all Medicare plans. However, it is classified as a tier 4 (out of 5 tiers) drug in the Medicare formulary. The higher the tier, the more out-of-pocket expense you have when purchasing a prescription.
Why Is Pimozide So Expensive?
High prices often reflect research and development investment, patent protections, and distribution costs. For prescription drugs with a broad user base, those costs are recouped through the high sales volume resulting in a relatively low per-unit price.
Drugs like pimozide, with an extremely limited efficacy range, are forced to spread the cost of development over a much smaller sales volume, resulting in a higher per-unit cost.
Producing limited runs of pills results in higher per-pill manufacturing and packaging expenses, adding yet another layer of additional cost to the final tally as well.
Patients are encouraged to compare prices, use coupons, and seek patient assistance programs to minimize expenses.
Pimozide Alternatives
Several drugs exist that work in similar ways to pimozide. However, very few have been officially approved for the treatment of Tourette’s syndrome. Because pimozide is generally used as a last resort when other drugs have not been effective, alternatives are limited.
Here are a few of the most commonly used alternative treatments for management of Tourette’s syndrome symptoms. Your doctor will be able to help you decide if alternative medications are appropriate for your scenario.
Haloperidol
Haloperidol is an antipsychotic medication marketed under the brand name Haldol and is most commonly used to manage the symptoms of Schizophrenia. However, Haloperidol has also been shown to reduce the motor tics and vocal outbursts associated with Tourette’s syndrome.
Aripiprazole
Aripiprazole is an atypical antipsychotic drug, marketed under the brand name Abilify, that is used to treat several conditions related to schizophrenia, Bipolar disorder, Autism, and Tourette’s syndrome. As a treatment for Tourette’s syndrome, aripiprazole is generally used for the management of symptoms in children aged 6 – 18.
Risperidone
Risperidone, marketed under the brand name Risperdal, is another antipsychotic drug that has been shown to reduce the frequency and severity of motor tics and vocal outbursts associated with Tourette’s syndrome.
FAQs About Pimozide
Do you still have questions? We’ve provided answers to some of the most frequently asked questions regarding the use of Pimozide below.
What are the common side effects associated with pimozide?
Common side effects of Pimozide may include headache, fever, dry mouth, blurred vision, drowsiness, and weakness. Some people may also experience more serious side effects including an increase in involuntary movements, irregular heartbeat, or signs of an allergic reaction like facial swelling, and difficulty breathing. These symptoms should be evaluated by a doctor immediately..
What is the brand name for pimozide?
Pimozide is commonly marketed under the brand name Orap.
How does pimozide function in treating Tourettes and similar disorders?
Pimozide helps suppress motor tics or vocal outbursts by inhibiting the brain’s uptake of dopamine. Suppressing the brain’s dopamine function has been shown to reduce the occurrence of unwanted tics, however, it does not cure them completely.
Is pimozide the most effective drug for treating Tourtette’s Syndrome tics?
There is still much that doctors do not fully understand about Tourette’s syndrome and other neurologic disorders. Managing the symptoms of these disorders is often a matter of finding the right combination of treatments that work for the individual patient. A treatment that works well for one patient may not be as effective for another. Pimozide is one of the drugs that has been shown to be effective in relieving the tics associated with Tourette’s for many patients.
What is the usual dosage range for pimozide, and how is it administered?
The usual dosage of pimozide varies and must be determined by a doctor. It can be taken with or without food. To minimize the negative impact of side effects like drowsiness, it’s often recommended to take it at bedtime, especially in children.
What are the contraindications and warnings associated with the use of pimozide?
Pimozide should not be used with certain medications or by people with conditions like prolonged QT interval or severe cardiovascular disorders. It is crucial to consult a healthcare provider for a full list of contraindications and warnings.
Are there any foods or beverages that I need to avoid while taking pimozide?
While taking Pimozide, it is important to avoid eating grapefruit or drinking grapefruit juice as it can increase drug levels in the body and lead to serious side effects. Alcohol should be avoided to reduce the risk of oversedation. Patients should maintain a regular diet unless advised otherwise by their doctor.
Is pimozide used to treat other disorders or just Tourette’s Syndrome?
Pimozide is primarily used for suppressing the motor tics and vocal outbursts associated with Tourette’s syndrome. In certain cases, it may also be used to treat schizophrenia and other psychiatric disorders.
Is pimozide safe for pregnant women or nursing mothers?
The safety of Pimozide for pregnant women or nursing mothers has not been well-established. Babies born to mothers taking pimozide in the final trimester of pregnancy may be at risk of suffering muscle spasms and withdrawal symptoms. It is essential to consult a healthcare professional to weigh the risks and benefits before continuing or starting pimozide during pregnancy or breastfeeding.
Our Guarantee For Buying Pimozide From A Canadian Pharmacy Partner
At MyRx Outlet, we are committed to delivering safe, high-quality medications that you can trust. We adhere to strict regulations in every country we operate in, ensuring that your order is handled by a licensed Canadian pharmacy or a trusted partner overseas. Each medication has been legally approved by Health Canada or other respected authorities. To purchase Pimozide at a discounted rate, call 1-888-551-2467.
IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.
