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Mavenclad (Cladribine)
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Mavenclad is the brand name of a medication that uses the active ingredient cladribine to treat multiple sclerosis relapses. It isn’t a cure for the condition, but it can help prevent certain cells of the immune system, lymphocytes, from attacking certain nerves in the spinal cord and brain.
This medication is classified as an antimetabolite. It treats MS by causing a decrease in the immune system cells that have been attacking the patient’s body. These attacks are what causes the symptoms of MS that can include vision problems, difficulty walking, tingling, and numbness.
Mavenclad is used for patients who are having MS relapses. With this form of MS, there are times when the patient goes into remission and has no symptoms or very few. Then, flare-ups occur and the symptoms become worse. This medication is approved for treating both relapsing-remitting MS and active secondary progressive MS.
Because Mavenclad can come with so many side effects, it generally isn’t the first line of treatment for MS. It’s generally chosen for a patient when they have tried other medications that didn’t work well for them or came with too many side effects.
Labeled Warnings of Mavenclad
Mavenclad has boxed warnings, the most serious type of warning issued by the FDA. The first of these is that this medication may increase a patient’s cancer risk. This risk includes developing ovarian, skin, and pancreatic cancers. This risk makes it important to follow a specific treatment schedule. Mavenclad is given to a patient for two treatment courses. After that, it can’t be taken anymore for the next two years or more.
If you’ve ever had cancer, it may not be safe to take this medication. It’s important to go for cancer screenings as directed by your doctor. You may need to get a colonoscopy, a skin exam, or a mammogram to rule out cancer.
The boxed warnings also include a warning about the risks to fetuses. This medication can cause harm to a fetus, so it shouldn’t be taken by pregnant women. If you’re able to get pregnant, it’s important to use reliable birth control. Keep using it for six months after you finish taking Mavenclad. If you take birth control pills, you need to also use a reliable barrier method such as condoms.
Precautions and Warnings for Mavenclad
The boxed warnings about developing cancer and the danger to fetuses must be heeded by patients. If you take birth control pills, they can be made less effective by Mavenclad. Don’t take this medication if you’ve ever had an allergic reaction to it.
Let your doctor know if you’ve had a vaccine in the four to six weeks before starting Mavenclad. If you’re a woman, you will likely have to take a pregnancy test before starting this medication.
Warnings
You shouldn’t take Mavenclad if you have any of the following:
- Cancer
- HIV or AIDS
- Pregnancy
- Liver impairment that’s moderate to severe
- An infection, such as hepatitis B or C or tuberculosis, that is currently active
- Currently breastfeeding
Medical History
It’s important to tell your doctor about your full medical history before you take this medication. There are many conditions that may cause a doctor not to prescribe this medication unless it’s clearly needed and other medications have failed. These conditions include:
- Weak immune system
- Heart problems
- Having received blood transfusions
- Kidney disease
- Liver disease
- Heart problems
- An infection that’s chronic or active
Side Effects of Mavenclad
There is a wide range of possible side effects for patients taking Mavenclad. There are so many side effects that this medication is often a last choice after other MS medications have failed.
It’s also possible to have an allergic reaction to this medication. If this happens, you could experience effects such as trouble breathing, hives, and/or swelling of the throat, lips, tongue, or face. If you experience these effects, get emergency medical care right away.
Mild Side Effects
There are several mild side effects that may go away after one to two weeks. These include:
- Headache
- Catching a cold or another upper respiratory tract infection
- Nausea
- Insomnia
- Hair loss
- Joint pain
Serious Side Effects
There are also side effects that can be more serious. These are less common, and they could signal that you need medical attention. These serious side effects include:
- White blood cell counts that are too low- this can lead to severe infections that can be life-threatening
- Reactivating a past infection such as herpes, tuberculosis, or hepatitis
- Heart failure
- Liver damage
- The rare brain infection progressive multifocal leukoencephalopathy
- Depression
- Difficulty concentrating
- Loss of appetite
- Pounding in the ears
- Nervousness
- A cough with mucus
- Hives
Drug Interactions of Mavenclad
Make sure that your doctor knows absolutely everything you’re taking before you start Mavenclad. This includes any herbal supplements, vitamins, and over-the-counter medications that you take. They may interact badly with Mavenclad, making either of the medications less effective or creating bothersome side effects. Some of the medications that may interact with Mavenclad include:
- Prednisone
- Methylprednisolone
- Sirolimus
- Tacrolimus
- Peginterferon beta – 1a
- Interferon beta – 1b
- Interferon beta – 1a
- Methotrexate
- Chemotherapy drugs
- Carbamazepine
- Stavudine
- Lamivudine
- Zidovudine
- Ribavirin
- Rifampin
- Ritonavir
- Dipyridamole
- Nifedipine
- Cyclosporin
- Eltrombopag
- Hormonal birth control
- John’s wort
- Curcumin
Strengths and Dosages of Mavenclad
Mavenclad comes in one strength- 10 mg tablets. These are generally taken once a day, though you may be prescribed them twice a day, depending on several factors. This medication is taken for two specific treatment courses, totaling two years of treatment. Each course of treatment with Mavenclad includes two cycles each year that are about one month apart from each other. The cycles are generally four to five days in length. The dosage that you will take will largely depend on your weight.
After you’ve taken the two courses of treatment with Mavenclad, you can’t take it again for the next two years or more. This is to mitigate your risk of developing cancer.
| Mavenclad tablet: | 10 mg |
Cost of Mavenclad in America
Taking two courses of treatment over two years will cost about $238,000 in total. That’s about $119,000 per year. It can cost even more than this, depending on the pharmacy you choose. This medication is so expensive because it is a brand-name medication that’s in high demand for patients who have tried other MS medications only to have them fail.
There’s also no generic of this medication, giving it no direct competition. It’s also a newer medication, being FDA-approved in 2019.
Are There Mavenclad Alternatives?
While there’s no generic to provide direct competition, there may be drugs that a doctor can prescribe instead of Mavenclad. These include:
FAQs of Mavenclad
What does Mavenclad treat?
It treats types of multiple sclerosis that include relapses of the disease. It’s generally a last-chance drug for treating MS that continues to present with flare-ups.
What is Mavenclad used for?
It’s used to treat patients who have MS that keeps relapsing with new flare-ups.
How does Mavenclad work?
Mavenclad works to treat MS by lowering the number of immune system cells that attack an MS patient’s body. The attack of these cells is what causes MS and the symptoms that come with it.
How long does Mavenclad stay in your system?
It takes about a week for the active ingredient in Mavenclad to leave the body.
When was Mavenclad approved?
It was first approved in 2019.
How long do Mavenclad side effects last?
They often last no more than a few days to a couple of weeks. However, it’s possible for them to last longer or to last indefinitely. It’s hard to predict when the side effects will stop or even if they will stop.
How do you take Mavenclad?
This medication comes in oral tablets that are swallowed. With this medication, they can’t be chewed or crushed. Swallow it with plenty of water so that the pill washes down into the stomach. It’s taken for two cycles a year for two years. After that, it has to be avoided for at least two years.
Who is the maker of Mavenclad?
Merck is the maker of this medication.
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IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.
