Notice: Images are for illustration purposes and may not exactly represent the product you receive. Brand-name medications may look different due to their country of origin—for example, Canadian products display "PR" on the packaging by law. For generic medications, we cannot guarantee a specific manufacturer, so appearances may vary. Rest assured, the medication, dosage, and active ingredients will be exactly as prescribed. Your trust is important to us, and we're committed to providing you with safe and effective medications.
Efudex Cream (Fluorouracil)
How To Buy Efudex Cream Online
Place Your Prescribed Efudex Cream Dosage In Your Cart
Complete Checkout
Upload Your Efudex Cream Prescription
MyRx Outlet does not ship any medication without a valid and matching prescription from a U.S. prescriber. We reserve the right to refuse service if there is reason to believe the prescription has been fabricated or altered.
Why Buy Efudex Cream (Fluorouracil) from MyRx Outlet?
At MyRx Outlet, we believe everyone deserves access to affordable, high-quality prescription medications. By delivering directly to customers in the United States, we offer a trusted and cost-effective solution for your healthcare needs. Here’s what sets us apart:
Save More with Canadian Pricing
Take advantage of Canada’s lower medication costs, ensuring you get the same high-quality prescriptions at prices far below what you’d typically pay in the U.S.
Hassle-Free Prescription Transfers
Let us handle the details. Our licensed pharmacy team will contact your local pharmacy or prescriber’s office to transfer your prescription—quickly, easily, and at no cost to you.
Personalized Support When You Need It
As a valued customer, you’ll have access to free consultations with our experienced pharmacy team. Whether you have questions about your medication or need advice, we’re here to help.
Earn Rewards by Sharing
Love MyRx Outlet? Refer friends and family and enjoy discounts as a thank-you for spreading the word.
Your Privacy, Our Priority
We understand the importance of discretion. Every order is packaged securely and shipped directly to your door, ensuring your privacy is always protected.
Expert Care You Can Trust
Our dedicated team of healthcare professionals is committed to providing the support and care you deserve, making MyRx Outlet your go-to for reliable medication solutions.
Efudex (Fluorouracil topical) is a topical medicine that treats scaly overgrowths of skin actinic keratosis (a skin condition caused by long-term exposure to ultraviolet (UV) light).
Efudex works by absorbing and preventing cancer DNA cells from copying itself when applied to the affected area. It should be noted that cancer cells develop more rapidly and take up Fluorouracil quickly.
It also treats superficial basal cell carcinoma (the most common type of skin cancer). It is classified as an antimetabolite and is available in:
- Topical Solution
- Cream
Precautions and Warnings with Efudex
Efudex has potential risks and warnings and the application can worsen underlying conditions if used without checking your medical history.
Efudex may make you more sensitive to sunlight and the doctor advises you to avoid going out in the sunlight for long periods.
You should inform your doctor about the products (prescription and over-the-top medicines along with hormonal and herbal medicine) before a procedure. A healthcare professional may not set a treatment program with Efudex for pregnant or breastfeeding women due to the risks and warnings increasing the chances of harming the child.
You should inform your doctor if you have a history of the following conditions before using Efudex:
- Enzyme deficiency (dihydropyrimidine dehydrogenase – DPD)
- Skin allergies (open sores, infected, irritated, red skin)
Efudex Side Effects
A patient can experience a range of side effects when using Efudex at the targeted area site and it could be different. It targets specific skin conditions, and some patients can experience more pronounced reactions depending on individual sensitivity and treatment duration.
The chances of a patient developing serious side effects because of the medicine are rare. However, it’s important to manage them as it could become a life-threatening condition.
Therefore, patients are informed of potential outcomes and discuss their concerns about side effects before starting to use the medicine.
The common and serious side effects of Efudex are:
Common Side Effects
- Blood vessels appearing under the skin
- Skin allergies and rashes
- Inflamed skin accompanied by pain, itching, burning, and irritation
Serious Side Effects
- Abdominal or stomach pain
- Bloody stools/diarrhea
- Respiratory issues
- Pain or swelling at the application site
- Severe itching, burning, or irritation
- Eyesight problems
Drug Interactions with Efudex
It is important to discuss your concerns about Efudex’s drug interactions with any medicines you are taking as it compromises its efficacy or lead to adverse effects. Your doctor may adjust the dosage or recommend safe and effective treatment plans to treat your conditions.
Efudex may interact with other medications, which can reduce its effectiveness or increase the chance of side effects. Your doctor may not prescribe Efudex if you are on the following medicine:
- Acenocoumarol
- Warfarin
- Azanidazole
- Tinidazole
- Benznidazole
- Isoconazole
- Metronidazole (found in Flagyl and MetroGel)
- Allopurinol
- Secnidazole
- Nimorazole
- Phenprocoumon
- Oxypurinol
- Cimetidine
- Methotrexate
- Tamoxifen
- Levoleucovorin
- Ornidazole
- Thiamine
- Levamisole
- Fosphenytoin
- Phenytoin
- Leucovorin
Strengths and Dosages of Efudex
Efudex is available in the following strengths:
- Efudex 2%
- Efudex 5%
The ingredients (active and inactive) in the topical solution and cream variants of the medicine are:
| Strengths | Forms | Active Ingredients | Inactive Ingredients |
| 2% and 5% | Topical Solution | Fluorouracil | Aminomethane, tris (hydroxymethyl), propylparaben, disodium edetate, methylparaben, hydroxypropyl cellulose, propylene glycol. |
| 2% and 5% | Cream | Fluorouracil | White petrolatum, stearyl alcohol, purified water, methylparaben, propylene glycol, polysorbate 60, and propylparaben. |
The medicine should be applied once or twice at the same time daily. You should not use it just before bedtime because the medicine can spread to other parts of the body when coming into contact with pillows or bed sheets.
Efudex should not be applied on irritated, peeling, and infected skin or on open wounds. It can be used on these areas after they are fully healed.
Your doctor may prescribe Efudex for up to six weeks. The targeted area may have an undesirable appearance during the healing process, which may take several weeks.
Efudex must be applied according to the treatment plan prescribed by your healthcare provider or the product description in the package.
You need to make sure the following while using Efudex:
- Wash your hands before and after each application.
- Apply the medicine to the topical solution/cream via a non-metal applicator, cotton bud, or rubber glove to apply the cream/solution.
- Avoid getting Efudex on mucous membranes like the eyes, nose, or mouth.
Cost of Efudex in America
Efudex is covered by most insurance plans, but terms and conditions may vary depending on the insurance provider and the individual’s policy. The patients should discuss the coverage details and any potential out-of-pocket costs with their insurance provider or pharmacist.
Efudex can set you back around $148.91 in the United States without insurance. The prices may vary depending on:
- The pharmacy from where it was purchased
- Insurance coverage
- Treatment plan
Why is Efudex so expensive?
Efudex can be expensive without insurance coverage in the US because it is a “chemotherapy drug” that treats precancerous skin conditions and certain types of skin cancer.
There are limited generic equivalents available and lack of market competition allows the manufacturer to maintain higher prices. It is a prescription drug with no over-the-counter alternatives while many insurance plans do not cover Efudex leaving no other option for patients but to purchase the medicines.
Efudex Alternatives
Your healthcare provider may recommend Efudex alternatives depending on factors such as the extent of the skin condition, patient tolerance, and desired treatment outcomes.
You should discuss these options with a healthcare professional before self-medicating with alternative versions of Efudex. Your doctor will decide the best possible option depending on their efficacy along with your condition.
The alternatives of Efudex are:
- Fluorouracil topical
- Picato
- Solaraze
- Aldara
- Voltaren
- Imiquimod topical
- Carac
- Santyl
- Ameluz
- Klisyri
- Fluoroplex
- Aminolevulinic acid topical
- Tolak
FAQs of Efudex
What is Efudex?
Efudex is a topical solution that treats precancerous skin conditions and certain types of skin cancer like basal cell carcinoma. It stops abnormal cancer cells from copying themselves in the body.
How to use Efudex for wrinkles?
Efudex is not recommended for treating wrinkles and is prescribed for medical conditions such as actinic keratosis and skin cancer. There are alternative versions available that reduce wrinkles which your healthcare provider can recommend.
Should you moisturize after using Efudex?
You can use moisturizer to soothe the skin and alleviate dryness or irritation caused by using Efudex after 30 minutes after applying the medicine.
How to soothe Efudex treatment?
A gentle application of moisturizer or soothing cream can be used to soothe skin during Efudex treatment after 30 minutes. You should not use harsh soaps and hot water, and protect the treated areas from excessive sun exposure.
When can I wear makeup after Efudex treatment?
You are recommended to wait until the skin has healed from Efudex treatment before applying makeup. Your healthcare provider can guide you on when it is safe to wear makeup.
How long does Efudex stay in your system?
Efudex stays in your system for two to four weeks after getting absorbed through the skin and metabolized in the body. It does not stay in for an extended period once treatment is discontinued.
How to apply Efudex?
Efudex should be applied thinly and evenly to clean, dry skin using an applicator or a cotton bud.
How long after taking Efudex can I shower?
You should wait for 30 minutes after applying Efudex before showering or washing the treated area as it allows the medication to be absorbed properly.
Our Guarantee For Buying Efudex Cream From A Canadian Pharmacy Partner
At MyRx Outlet, we are committed to delivering safe, high-quality medications that you can trust. We adhere to strict regulations in every country we operate in, ensuring that your order is handled by a licensed Canadian pharmacy or a trusted partner overseas. Each medication has been legally approved by Health Canada or other respected authorities. To purchase Efudex Cream at a discounted rate, call 1-888-551-2467.
IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.
