Eucrisa is a topical prescription medication that is used to treat mild-to-moderate eczema, also known as atopic dermatitis. It contains the active ingredient crisaborole, which belongs to a class of drugs called phosphodiesterase 4 (PDE-4) inhibitors. Eucrisa works by reducing inflammation and controlling the symptoms associated with eczema.


Eczema, also known as atopic dermatitis, is a chronic inflammatory skin condition that results in patches of dry, itchy, and irritated skin. It can affect individuals of all ages, from infants to adults, and often appears in early childhood. Eczema can vary in severity, with some individuals experiencing mild symptoms and others dealing with more intense flare-ups.There are several types of eczema, each with its own unique characteristics (Example: Dyshidrotic Eczema: Occurring on the palms of the hands and soles of the feet, often presenting as small blisters). The exact cause of eczema is not yet fully understood, but it is believed to be a combination of genetic and environmental factors. People with a family history of allergies, asthma, or eczema are more likely to develop this condition. Additionally, certain triggers can worsen eczema symptoms or lead to flare-ups.

Warnings and Precautions

While Eucrisa can be effective in managing eczema symptoms, it is important to be aware of the warnings and precautions associated with its use to ensure safe and proper treatment.

Allergic reactions

If you have a known allergy to crisaborole or any other ingredients in Eucrisa, it is essential to avoid using this medication. Allergic reactions can range from mild skin irritation to severe symptoms such as swelling, difficulty breathing, or anaphylaxis. If you experience any signs of an allergic reaction, seek medical attention immediately.

Open wounds or infections

Eucrisa should not be applied to open wounds or areas of infected skin. The medication is intended for intact skin only and may cause further irritation or delay the healing process if applied to broken skin. If you have any open wounds or signs of infection, consult your healthcare provider before using Eucrisa.

Pregnancy and breastfeeding

The safety of Eucrisa during pregnancy and breastfeeding has not been established. It is important to discuss with your doctor the potential risks and benefits of using Eucrisa if you are pregnant or breastfeeding. Your healthcare provider can help you make an informed decision based on your individual circumstances.

Pediatric use

Eucrisa is approved for use in children aged 2 years and older. However, it is always recommended to consult with a pediatrician before using any medication on a child. The doctor can assess the child’s condition and provide appropriate guidance on the use of Eucrisa.

Eye contact

Eucrisa is for external use only and should not come into contact with the eyes. If accidental eye exposure occurs, rinse the eyes thoroughly with water and seek medical attention if irritation persists.

Side Effects

While it is effective for many individuals, it’s important to be aware of potential side effects that can occur.

Common Side Effects

  • Burning or stinging sensation: Upon application of Eucrisa, some individuals may experience a temporary burning or stinging sensation at the site of application. This sensation typically subsides quickly and should not cause significant discomfort.
  • Itching or dryness: It is possible to experience mild itching or dryness in the treated area. This is usually a temporary side effect and can be managed with moisturizers or emollients.
  • Redness or irritation: Eucrisa may cause localized redness or irritation on the skin. This is a common side effect that typically resolves without intervention.
  • Headache: In some cases, individuals may experience a mild headache after using Eucrisa. This side effect is generally short-lived and does not require medical attention.
  • Nausea: Although uncommon, some individuals may experience mild nausea as a side effect of Eucrisa. If you experience persistent or severe nausea, it is advisable to consult your healthcare provider.

Rare Side Effects

  • Allergic reactions: Although uncommon, some individuals may develop an allergic reaction to Eucrisa. Signs of an allergic reaction may include hives, itching, swelling, difficulty breathing, or dizziness. If you experience any of these symptoms, seek immediate medical attention.
  • Worsening of eczema: In rare cases, individuals may experience a worsening of their eczema symptoms after using Eucrisa. If you notice increased redness, swelling, or severe itching, discontinue use and consult your healthcare provider.
  • Skin infection: While Eucrisa is primarily used to treat atopic dermatitis, there is a small risk of developing a skin infection. If you notice signs of infection such as increased pain, warmth, redness, or the presence of pus, seek medical attention promptly.
  • Headache or dizziness: Rarely, some individuals may experience persistent or severe headaches, or even dizziness after using Eucrisa. If you encounter these symptoms, it is advisable to consult your healthcare provider.
  • Eye irritation: Eucrisa is not meant to be applied to the eyes, but accidental contact may occur. If you experience eye irritation or any changes in vision, rinse your eyes thoroughly with water and seek medical advice.

Severe Side Effects

  • Severe allergic reaction: In rare cases, Eucrisa may trigger a severe allergic reaction known as anaphylaxis. Symptoms may include difficulty breathing, chest tightness, rapid heartbeat, severe swelling, or dizziness. Anaphylaxis is a medical emergency, and immediate medical attention is necessary.
  • Severe skin irritation or burning: Although rare, some individuals may experience severe skin irritation or a burning sensation that persists or worsens with Eucrisa use. Discontinue the medication and seek medical help promptly if you encounter this side effect.
  • Unusual fatigue or weakness: While uncommon, Eucrisa may cause extreme fatigue or weakness. If you experience these symptoms to a severe extent, it is important to consult your healthcare provider.
  • Mental health changes: Rarely, individuals using Eucrisa may experience changes in mood or behavior. If you notice any unusual mental health changes such as increased anxiety, depression, or thoughts of self-harm, seek immediate medical assistance.

Severe side effects of Eucrisa are extremely rare but have been reported in a few isolated cases. While these occurrences are unlikely, it is crucial to be aware of them. If you experience any of the mentioned severe side effects, contact your healthcare provider immediately.

Drug Interactions

While Eucrisa is generally considered safe and effective, it is essential to be aware of any potential drug interactions that may occur when taking this medication alongside other drugs. By understanding the possible interactions, you can ensure the safe and optimal use of Eucrisa for your condition.


Eucrisa is not typically recommended for use in combination with topical corticosteroids due to the limited data available on their combined effects. It is advisable to consult your healthcare provider before using Eucrisa alongside any steroid medications to ensure they are compatible and to avoid any potential adverse reactions.


Immunosuppressant drugs, such as cyclosporine or methotrexate, are commonly used in the treatment of various autoimmune disorders. While there is no known specific interaction between Eucrisa and immunosuppressants, it is crucial to discuss their concurrent use with your doctor to evaluate any potential risks or benefits.


Some antibiotics, particularly those from the macrolide class (e.g., erythromycin, clarithromycin), may interact with Eucrisa. These interactions are generally minimal and do not pose significant risks. However, it is always advisable to inform your healthcare provider about any antibiotics you are taking to ensure there are no potential complications.

Antifungal Medications

Eucrisa may be used alongside antifungal medications, such as ketoconazole or miconazole, without any known adverse interactions. However, it is essential to follow the prescribed guidelines and consult your healthcare provider to ensure the safe and effective use of both medications.

How To Use

If you have been prescribed Eucrisa by your healthcare provider, it is important to understand how to use it correctly to maximize its effectiveness.

1. Clean the Affected Area: Before applying Eucrisa, gently cleanse the affected area with a mild, fragrance-free cleanser and lukewarm water. Avoid using hot water as it can further irritate the skin. Gently pat the area dry with a soft towel.

2. Apply a Thin Layer: Using clean fingertips, take a small amount of Eucrisa and apply a thin layer to the affected area. Rub it in gently until the ointment is evenly distributed. Avoid using excessive pressure or rubbing, as this may aggravate the skin.

3. Wash Your Hands: After applying Eucrisa, wash your hands thoroughly to remove any residue. This will help prevent accidental contact with the eyes or mouth, which may cause irritation.

4. Follow Your Healthcare Provider’s Instructions: It is crucial to follow your healthcare provider’s instructions regarding the frequency and duration of Eucrisa application. They will determine the most appropriate treatment plan based on the severity of your eczema and your individual needs.



To ensure the safe and effective use of Eucrisa, it is important to follow the prescribed dosing instructions provided by your healthcare professional.

Adults and Children 3 Years of Age and Older

  1. Apply a thin layer of Eucrisa to the affected areas of the skin twice daily.
  2. Gently rub the medication into the skin until it is fully absorbed.
  3. Wash your hands after applying Eucrisa unless the hands are the area being treated.

Children 2 to 3 Years of Age

  1. Apply a thin layer of Eucrisa to the affected areas of the skin twice daily.
  2. Gently rub the medication into the skin until it is fully absorbed.
  3. Wash your hands after applying Eucrisa unless the hands are the area being treated.
  4. The use of Eucrisa in children below 2 years of age is not recommended. Consult a healthcare professional for alternative treatment options.


If you have been prescribed Eucrisa, it’s important to store it properly to ensure its effectiveness and safety.

  • Store at Room Temperature: Eucrisa should be stored at room temperature, between 68°F (20°C) and 77°F (25°C). Avoid exposing the medication to extreme temperatures, such as direct sunlight or freezing conditions.
  • Keep it in the Original Container: Always keep Eucrisa in its original container. The container is designed to protect the medication from light and moisture, which can degrade its potency. Additionally, the packaging provides important information, such as the expiration date and usage instructions, that you may need to refer to.
  • Avoid Excessive Moisture: Moisture can affect the quality of Eucrisa. Make sure to keep the container tightly closed when not in use to prevent moisture from entering. Avoid storing the medication in the bathroom, where humidity levels are typically high. Instead, choose a dry and cool location for storage.
  • Do Not Freeze: Do not freeze Eucrisa. Freezing can alter the consistency and effectiveness of the medication. If your Eucrisa accidentally freezes, discard it and obtain a new prescription.
  • Keep Out of Reach of Children and Pets: Store Eucrisa in a safe place where children and pets cannot access it. Accidental ingestion of Eucrisa can lead to serious health complications.
  • Store Away from Heat Sources: Keep Eucrisa away from heat sources such as radiators, stoves, and direct sunlight. High temperatures can compromise the medication’s stability and effectiveness.
  • Avoid Humid Areas: Moisture can degrade the quality of Eucrisa. Avoid storing it in areas with high humidity, such as bathrooms. Instead, choose a dry and cool location for storage.
  • Do Not Share Eucrisa: Eucrisa is a prescription medication meant for individual use. It should not be shared with others, even if they have similar skin conditions. Each person’s treatment plan may differ, and sharing medication can lead to adverse effects or ineffective treatment.


1. Returning to a Pharmacy or Healthcare Facility: One of the safest ways to dispose of expired or unused medications is to return them to a pharmacy or healthcare facility. Many pharmacies have drug take-back programs that allow individuals to bring in their unwanted medications, including Eucrisa, for proper disposal. These programs ensure that the medications are disposed of in an environmentally friendly manner.

2. Contacting Local Authorities: If there are no drug take-back programs available in your area, you can contact your local authorities, such as the city or county government, for guidance on how to dispose of Eucrisa safely. They may provide instructions on proper disposal methods or direct you to designated collection sites or events.

3. Following FDA Guidelines: The U.S. Food and Drug Administration (FDA) provides guidelines for the safe disposal of medications. According to the FDA, you should not flush Eucrisa down the toilet or pour it down the drain unless specifically instructed to do so. Flushing medications can contaminate water sources and harm aquatic life. Instead, follow the specific disposal instructions provided by the medication’s label or the patient information leaflet.

4. Using Medication Disposal Bags: Another option for the disposal of Eucrisa is to use medication disposal bags. These bags are designed to safely and easily dispose of medications. You can typically find them at pharmacies or online. Follow the instructions provided with the disposal bag to ensure proper usage.

5. Mixing with Undesirable Substances: To prevent accidental ingestion, you can mix Eucrisa with an undesirable substance such as used coffee grounds or kitty litter. Place the mixture in a sealed plastic bag or container and dispose of it in your regular household trash. This method helps deter people or animals from retrieving and consuming the medication.

6. Avoiding Unapproved Disposal Methods: It is important to avoid certain disposal methods that can be harmful to the environment or others. Do not burn Eucrisa or dispose of it in a pit or landfill. These methods can lead to soil and water contamination. Additionally, do not give or sell your unused Eucrisa to others, as it is a prescription medication that should only be used under medical supervision.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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