Benzaclin is a prescription-only topical gel that combines two active ingredients: benzoyl peroxide and clindamycin. The gel is primarily used for the treatment of acne vulgaris, a common skin condition characterized by pimples, blackheads, and whiteheads. The combination of benzoyl peroxide and clindamycin makes Benzaclin an effective solution for mild to moderate acne cases.

The effectiveness of Benzaclin lies in the actions of its two main components – benzoyl peroxide and clindamycin. Benzoyl peroxide is renowned for its ability to target and eliminate the bacteria responsible for causing acne. It works by releasing oxygen upon application, creating an oxygen-rich environment that kills the bacteria thriving in clogged pores. Additionally, benzoyl peroxide helps to remove excess oil and dead skin cells, preventing further blockages. Clindamycin is an antibiotic that effectively reduces inflammation associated with acne. By inhibiting the production of bacterial proteins, clindamycin curbs the growth of acne-causing bacteria. This reduction in bacteria leads to a decrease in skin inflammation, promoting faster healing and a clearer complexion.

Benzaclin is an effective treatment option for individuals dealing with mild to moderate acne issues. It is especially useful for those whose acne is characterized by inflammatory papules and pustules. However, it’s essential to consult a dermatologist before starting any new skincare regimen, including Benzaclin, to ensure it’s the right fit for your specific skin type and condition.

Warnings and Precautions

Like any medication, Benzaclin comes with its share of warnings and precautions that users should be aware of.

  1. Consult a Dermatologist: Before starting any acne treatment, including Benzaclin, it’s essential to consult a dermatologist or healthcare professional. They can assess your skin type, severity of acne, and medical history to determine if Benzaclin is suitable for you.
  2. Patch Test: Perform a patch test before applying Benzaclin to your entire face. Apply a small amount of the product on a small area of your skin to check for any allergic reactions or irritation.
  3. Avoid Eye Area: Benzaclin is not intended for use around the eyes. Ensure you avoid contact with the eyes, as it may cause irritation and discomfort.
  4. Avoid Broken Skin: Do not apply Benzaclin on broken, irritated, or sunburned skin, as it can exacerbate the condition and cause further irritation.
  5. Avoid Sun Exposure: Benzoyl peroxide, one of the active ingredients in Benzaclin, may increase sensitivity to sunlight. Use sunscreen with at least SPF 30 when going outside to protect your skin from potential sunburn.
  6. Limit Sunlamp Exposure: Avoid using sunlamps or tanning beds while using Benzaclin, as it may lead to severe skin irritation.
  7. Pregnancy and Breastfeeding: If you are pregnant or breastfeeding, consult your healthcare provider before using Benzaclin. The safety of this medication during pregnancy and breastfeeding has not been established.
  8. Concomitant Use: Inform your healthcare provider about any other topical or oral medications you are using to avoid potential interactions.
  9. Avoid Harsh Cleansers: Refrain from using harsh cleansers, astringents, or exfoliants while using Benzaclin, as they can further irritate the skin.
  10. Acne Severity: Benzaclin is typically recommended for mild to moderate acne. If you have severe acne, your dermatologist may suggest alternative treatments.
  11. Storage: Store Benzaclin at room temperature, away from direct sunlight and heat, and keep it out of the reach of children.
  12. Medication Allergies: If you have a history of allergies to benzoyl peroxide, clindamycin, or any other medications, inform your healthcare provider before using Benzaclin.
  13. Avoid Contact with Hair and Clothing: Be cautious while applying Benzaclin to avoid contact with hair and clothing, as it may cause bleaching or discoloration.
  14. Gentle Application: Apply Benzaclin gently and avoid excessive rubbing or scrubbing of the skin.
  15. Don’t Overuse: Follow the prescribed dosage and application instructions. Overuse may lead to increased side effects without improving efficacy.
  16. Initial Worsening: Some users may experience initial worsening of acne before improvement. This is normal and usually subsides with continued use.
  17. Possible Side Effects: Be aware of potential side effects, such as dryness, redness, peeling, or burning sensation. If these side effects persist or worsen, consult your dermatologist.
  18. Not for Cystic Acne: Benzaclin is not effective for treating cystic acne. Consult your dermatologist for appropriate treatment options if you have cystic acne.
  19. Age Restrictions: Benzaclin is generally safe for individuals above the age of 12. If you are under 12 years old, consult your healthcare provider before use.
  20. Avoiding Sensitive Areas: Avoid applying Benzaclin to sensitive areas of the face, such as the lips and nostrils, as it may cause discomfort.
  21. Check Expiry Date: Ensure the product is within its expiration date before use.
  22. Not for Rosacea: Benzaclin is not suitable for the treatment of rosacea. If you have this condition, consult your dermatologist for appropriate treatment options.
  23. Medical Conditions: Inform your healthcare provider about any existing medical conditions, such as allergies, eczema, or asthma, before using Benzaclin.
  24. Keep Away from Pets: Keep Benzaclin out of reach of pets, as it can be harmful to animals.
  25. Follow the Instructions: Adhere to the usage instructions provided by your healthcare provider or on the product label.

Side Effects

While Benzaclin can be effective in clearing up acne, it’s essential to be aware of potential side effects that may occur during its use.

Common Side Effects

  1. Dryness and Peeling: One of the most common side effects of Benzaclin is skin dryness and peeling. This occurs due to the drying properties of benzoyl peroxide, which can lead to flaky and irritated skin.
  2. Redness and Irritation: Some users may experience redness and irritation at the application site. This is generally mild and tends to improve with continued use.
  3. Burning or Stinging Sensation: A burning or stinging sensation upon application is also common, especially during the initial stages of treatment.
  4. Itching: Itching is another frequent side effect, and it is typically mild. However, if itching becomes severe or persistent, it is essential to seek medical advice.
  5. Sensitivity to Sunlight: Benzoyl peroxide increases the skin’s sensitivity to sunlight, making it crucial to use sunscreen regularly to protect the skin from sunburn.
  6. Temporary Discoloration: In some cases, Benzaclin may cause temporary discoloration of the skin. This usually resolves once treatment is discontinued.

Rare Side Effects

  1. Allergic Reactions: Although rare, some individuals may experience allergic reactions to Benzaclin. Signs of an allergic reaction include hives, swelling, and difficulty breathing. If any of these symptoms occur, seek immediate medical attention.
  2. Severe Itching and Rash: In rare instances, Benzaclin can cause a severe itching sensation and a widespread rash. If this occurs, discontinue use and consult a healthcare professional.
  3. Eczema-like Reactions: Some individuals may develop eczema-like reactions characterized by red, itchy, and inflamed skin patches.
  4. Contact Dermatitis: Benzaclin can cause contact dermatitis, an allergic reaction that results from skin contact with the medication.

Severe Side Effects

  1. Severe Skin Irritation: In some cases, Benzaclin may cause severe skin irritation, including persistent redness, swelling, and extreme discomfort. If these symptoms occur, discontinue use and seek medical advice.
  2. Prolonged Peeling and Dryness: While mild dryness and peeling are common, some individuals may experience prolonged and severe peeling, leading to skin discomfort.
  3. Skin Discoloration: In rare instances, Benzaclin can cause skin discoloration that persists even after discontinuing the medication.
  4. Swelling and Skin Inflammation: Severe swelling and skin inflammation may occur in sensitive individuals.
  5. Gastrointestinal Upset: In some cases, the clindamycin component of Benzaclin may cause gastrointestinal upset, such as nausea and diarrhea.
  6. Photosensitivity: Severe photosensitivity can be a rare but significant side effect of Benzaclin, leading to severe sunburn upon minimal sun exposure.


Understanding the interactions with Benzaclin is crucial for ensuring safe and effective acne treatment.

Drug Interactions

  1. Retinoids: Combining Benzaclin with oral or topical retinoids can lead to excessive skin dryness and irritation. It’s advisable to use these medications at different times of the day or as directed by your healthcare provider.
  2. Sulfur-based Products: Using Benzaclin simultaneously with sulfur-based products may cause skin sensitivity and exacerbate dryness. Space out the application of these products to avoid skin irritation.
  3. Topical Antibiotics: Combining Benzaclin with other topical antibiotics may result in reduced efficacy and potential antibiotic resistance. Avoid using multiple topical antibiotics together unless advised by your dermatologist.
  4. Oral Antibiotics: Some oral antibiotics can interact with Benzaclin, affecting their absorption or effectiveness. Your healthcare provider will determine the best course of action if you need to take both medications.
  5. Products Containing Alcohol: Using products that contain alcohol, such as certain toners or astringents, alongside Benzaclin can cause excessive skin dryness and irritation. Opt for alcohol-free alternatives for better results.

Herbal Interactions

  1. Aloe Vera: Aloe vera gel can soothe and hydrate the skin, making it a potentially beneficial companion to Benzaclin. However, always perform a patch test and consult your dermatologist before using aloe vera with any prescription medication.
  2. Tea Tree Oil: Known for its antimicrobial properties, tea tree oil may enhance the antibacterial effects of Benzaclin. However, it can also be irritating to some individuals, so use with caution.
  3. Green Tea: Drinking green tea, rich in antioxidants, may complement your acne treatment. However, avoid applying green tea extracts topically along with Benzaclin, as it may lead to skin irritation.

Food Interactions

  1. Dairy Products: Some individuals experience increased acne breakouts when consuming dairy products. Although there is limited evidence of direct interactions with Benzaclin, avoiding excessive dairy intake may help manage acne better.
  2. High-Glycemic Foods: Diets rich in high-glycemic foods (e.g., sugary and processed foods) have been associated with acne flare-ups. Opt for a balanced diet with more whole foods for better skin health.
  3. Grapefruit: While this fruit is often associated with oral medications, it’s worth noting that grapefruit may interact with topical medications as well. Although there is no direct evidence for Benzaclin interactions, consider avoiding grapefruit-based skincare products.

How to Use

Using Benzaclin is relatively simple, but to ensure its effectiveness, it’s crucial to follow the correct application process.

  1. Cleanse Your Face: Before applying Benzaclin, wash your face gently with a mild cleanser and pat it dry. Make sure to remove all makeup, dirt, and excess oil, allowing the medication to penetrate the skin properly.
  2. Spot Test: If you are using Benzaclin for the first time, consider conducting a spot test. Apply a small amount of the gel on a small area of your skin and wait for 24 hours to check for any allergic reactions or irritation.
  3. Apply a Thin Layer: Squeeze a pea-sized amount of Benzaclin onto your fingertips. Gently apply a thin layer of the gel to the affected areas of your face. Avoid contact with your eyes, mouth, and any open wounds.
  4. Spread Evenly: Using a gentle circular motion, spread the gel evenly across your skin. Be cautious not to rub the gel vigorously, as it may cause irritation.
  5. Frequency of Use: Initially, start with once-daily application, preferably in the evening. After a week or two, if your skin tolerates the treatment well, you can gradually increase the application to twice daily.
  6. Moisturize: To prevent excessive dryness and flakiness, follow up with a non-comedogenic moisturizer after the gel has dried.
  7. Consistency is Key: For optimal results, use Benzaclin consistently as directed by your dermatologist. Remember, acne treatment is a gradual process, and improvements may take several weeks to become noticeable.


When it comes to managing acne, Benzaclin is a popular topical medication known for its efficacy. However, to achieve optimal results, it’s essential to understand and follow the dosing guidelines carefully.

Initial Application

Before applying Benzaclin, it’s crucial to cleanse the affected areas thoroughly with a mild cleanser and pat the skin dry. Take a pea-sized amount of the gel and apply it evenly to the affected areas. It’s essential to avoid contact with the eyes, mouth, and nose. For best results, apply Benzaclin once daily, preferably in the evening.

Maintenance Dosing

As your skin begins to improve, your healthcare provider may recommend reducing the frequency of Benzaclin application. This maintenance dose might involve applying the gel every other day or as instructed by your dermatologist. Always follow your doctor’s recommendations for the best outcomes.

Dealing with a Missed Dose

If you forget to apply Benzaclin at the scheduled time, apply it as soon as you remember. However, if it is close to the time of your next application, skip the missed dose and continue with your regular dosing schedule. Avoid doubling the dose to make up for the missed application, as this may increase the risk of skin irritation.

Signs and Symptoms of Overdose

Using excessive amounts of Benzaclin can lead to skin irritation, redness, and peeling. In some cases, it may cause an allergic reaction. If you experience severe itching, rash, swelling, or difficulty breathing after applying Benzaclin, seek immediate medical attention.


To ensure its effectiveness and safety, proper storage is crucial.

  1. Store at Room Temperature: Keep Benzaclin at room temperature, preferably between 68°F to 77°F (20°C to 25°C).
  2. Avoid Direct Sunlight: Protect the medication from direct sunlight, as exposure to light can degrade its active ingredients.
  3. Keep the Original Packaging: Always store Benzaclin in its original packaging. The packaging is designed to protect the medication from environmental factors.
  4. Close Tightly After Use: Ensure the cap of the Benzaclin tube is tightly closed after each use to prevent air exposure.
  5. Keep Away from Moisture: Moisture can affect the stability of the medication. Store Benzaclin in a dry place.
  6. Avoid Extreme Temperatures: Never store Benzaclin in extremely hot or cold environments, such as a car during summer or winter.
  7. Keep Out of Reach of Children: Store Benzaclin in a secure location, out of reach of children and pets.
  8. Don’t Freeze: Freezing temperatures can damage the active ingredients. Avoid storing Benzaclin in the freezer.
  9. Check Expiry Date: Before use, always check the expiry date on the packaging. Expired medication may lose its efficacy.
  10. Avoid Humid Environments: High humidity can lead to the degradation of the medication. Store Benzaclin away from humid areas like bathrooms.
  11. Traveling with Benzaclin: When traveling, store Benzaclin in a travel-sized toiletry bag away from direct sunlight.
  12. Don’t Transfer to Another Container: Avoid transferring Benzaclin to another container, as it may compromise its quality.
  13. Don’t Share Medication: Never share your Benzaclin with others, as it may lead to cross-contamination.
  14. Store Away from Heat Sources: Keep Benzaclin away from heat sources like radiators and stoves.
  15. Keep in an Upright Position: Store the medication in an upright position to prevent leakage.
  16. Don’t Store in the Bathroom: Although common, storing Benzaclin in the bathroom exposes it to heat and humidity. Find an alternative storage location.
  17. Avoid Storing Near Electronic Devices: Electronic devices like hairdryers and chargers can emit heat, affecting the medication’s quality.
  18. Check for Discoloration: If Benzaclin changes color, texture, or develops an unpleasant odor, discard it.
  19. Read Manufacturer’s Guidelines: Follow the storage instructions provided by the manufacturer.
  20. Separate from Cosmetics: Keep Benzaclin away from cosmetics, as they may react with the medication.
  21. Avoid Leaving the Cap Off: Leaving the cap off the tube may cause the medication to dry out.
  22. Keep in a Dark Place: Store Benzaclin in a dark place, away from direct light exposure.
  23. Store in a Medicine Cabinet: A medicine cabinet is an ideal storage location, providing protection from environmental elements.
  24. Check for Signs of Contamination: Inspect Benzaclin regularly for any signs of contamination or foreign particles.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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