Videx, a nucleoside, falls under a class of drugs that is best known for reversing transcriptase inhibitors but does not cure HIV. This drug is used in collaboration with other HIV drugs like tenofovir DF to control HIV infection and boost your immune system.

Improving human immunity helps to reduce the risk of HIV complications like cancer, tuberculosis, pneumonia, and the formation of new infections. In turn, this helps to improve the overall quality of life of the infected people.

You can reduce the risk of transmitting HIV by taking the HIV drugs as advised. During this time, your doctor may recommend latex or polyurethane condoms/dental dams for sexual activity. You should also not share needles/syringes, toothbrushes, or razors that may have contact with body fluids like blood and saliva.

How Does Videx Work?

HIV is a retrovirus that transforms its RNA genome into DNA in host cells. This conversion occurs via reverse transcriptase. Videx (Didanosine) inhibits reverse transcriptase, an enzyme needed for HIV replication.

Videx blocks reverse transcriptase to stop HIV replication in cells. This inhibits viral replication, slowing HIV infection and lowering bloodstream viral load. By doing so, this medication boosts the immune system and prevents HIV consequences.

Videx Precautions and Warnings

Videx is a very effective drug in decreasing the amount of HIV in your body. However, the following warnings and precautions should be considered for maximum efficacy and reliability.

  • Pancreatitis: Videx can cause pancreatitis, a potentially serious pancreatic inflammation. Pancreatitis symptoms, including severe abdominal discomfort, nausea, vomiting, and fever, should be observed. You should immediately stop taking Videx if pancreatitis is detected.
  • Liver failure: Prolonged use of Videx can damage or kill the liver. Patients with liver illness or increased liver enzymes should be continuously monitored while using Videx. Jaundice, abdominal pain, and black urine are liver disease symptoms that require immediate medical attention.
  • Peripheral Neuropathy: This drug can cause peripheral neuropathy, resulting in tingling, numbness, or pain in the hands and feet. Notify your doctor about peripheral neuropathy symptoms.
  • Immune Reconstitution Inflammatory Syndrome (IRIS): In HIV-infected patients taking antiretroviral therapy, including Videx, immune reconstitution inflammatory syndrome (IRIS) has been reported. As the immune system recovers, this condition may aggravate pre-existing illnesses or cause new infections or inflammatory diseases. Videx-treated patients should be monitored for IRIS.
  • Lactic Acidosis: This drug causes lactic acidosis and hepatomegaly, a dangerous metabolic disorder defined by high blood lactic acid levels. Patients should seek medical assistance if they experience rapid breathing, muscle pain, weakness, gastrointestinal discomfort, or unexplained weight loss.
  • Resistance: Like other antiretrovirals, Videx can cause drug resistance if administered inconsistently or if the virus mutates. Patients should follow the dose plan to avoid resistance.
  • Pregnancy and Breastfeeding: If you are a pregnant or breastfeeding woman, make sure to consult your doctor before using this medication. This drug may not be safe for your baby.

Videx Side Effects

Didanosine side effects range in degree and occurrence. They include:

Common Side Effects

  • Nausea
  • Mild Stomach pains
  • Vomiting
  • A frequent, watery bowel output
  • Headache: Mild to severe head pain
  • Rash: Redness, itching, or inflammation
  • Pain or cramping in the abdomen
  • Fatigue: Tiredness

Severe Side Effects

Please report severe or persistent adverse effects to your doctor immediately. Intolerable or severe adverse effects may require therapy changes, or your doctor may recommend replacing the drug with alternatives. Serious adverse effects can develop and may include:

  • Pancreatitis: Pancreatic inflammation causing severe abdominal discomfort.
  • Liver Problems: Liver toxicity causes jaundice, stomach pain, black urine, and weariness.
  • Lactic Acidosis: Blood lactic acid buildup causes fast breathing, muscle soreness, weakness, stomach discomfort, and unexplained weight loss.
  • Immune Reconstitution Inflammatory Syndrome (IRIS): IRIS is a sudden worsening of pre-existing infections or developing new infections or inflammatory disorders when the immune system recovers.

Videx Drug Interactions

Drug interactions can alter pharmaceutical effects or cause dangerous side effects. Please list all your products, including prescription/nonprescription and herbal products, and discuss them with your doctor and pharmacist. Do not start, stop, or change medication dosage without the doctor’s consent.

Products that may interact with this medication include:

  • Tenofovir: Using Videx and tenofovir may cause pancreatitis and liver damage.
  • Ribavirin: Videx may interact with ribavirin, a hepatitis C antiviral, raising the risk of lactic acidosis and liver damage.
  • Proton Pump Inhibitors: The absorption of Videx may be reduced by proton pump inhibitors (PPIs), which treat stomach acid problems. It would be best if you took Videx 1 hour before or 2 hours after PPIs to minimize possible interaction effects.
  • Tetracyclines and quinolones may interact with Videx, reducing its absorption and efficacy. Taking these drugs 2 hours before or after Videx may mitigate the effects of their interaction.

Videx Strengths and Dosages

Videx dosage will depend on the age and weight of the patient, how severe the condition is, and your general health profile. The standard dosages include:

Patient’s Weight Maximum dosage (once daily) Minimum dosage (twice a day)
At least 60kg and above 400mg 250mg
30-59kg 200mg 150mg
10-29kg 150mg 100mg
Children less than 10kg 100mg 75mg


Take Videx capsules by swallowing them whole. Avoid breaking, crushing, or opening the capsule beforehand. You can use water to take the drug, but avoid using soft drinks and other acidic juices as they may cause allergies.

These capsules should be administered on an empty stomach for increased efficacy. Taking the medication with food reduces the absorption of Videx.

If you miss a dose of Videx, take it as soon as you remember. However, if it is time for the next dose, you can skip the missed dose and continue with the regular dosing schedule. Refrain from doubling the dosage to make up for the missed dosage.

Videx Alternatives

Different medicines can be used instead of Videx to inhibit the reverse transcriptase enzyme necessary for HIV replication. Some of these alternatives include:

  • Biktarvy– A combination of three drugs, namely tenofovir alafenamide, bictegravir, and emtricitabine, that is used in the treatment of HIV-1.
  • Descovy– Used alongside other HIV-1 medicines to treat and prevent the risk of acquiring HIV-1.
  • Other medication, including zidovudine, lamivudine, abacavir, tenofovir, and emtricitabine.

The choice of alternative drugs depends on individual factors, including their health profile, drug interactions, and possible side effects. You should consult a healthcare provider to help you figure out the best drug based on your circumstances.

FAQs of Videx

What should I avoid while taking Videx?

Avoid drinking alcohol while taking Videx since alcohol can increase the risk of pain and inflammation of the pancreas or cause liver damage.

What should I do if I take an overdose?

In case you take an overdose of the drug and experience trouble breathing, dizziness, and muscle pain, seek medical attention immediately.

What is Videx used to treat?

Videx is a prescription medicine used in the treatment and prevention of HIV replication in children and adults.

Can Videx prevent HIV transmission?

No. The drug does not prevent a patient infected with HIV from passing the virus to another person. HIV transmission can be prevented by practicing safe sex, avoiding sharing needles, as well as using HIV prevention medication.

Can Videx cure HIV?

No. The drug does not cure or kill HIV. It prevents the virus from reproducing, leading to a low viral load, which reduces complications.

What is the cost of Videx in America?

The 10mg/ml Videx price is about $125  for a 200 ml supply for cash-paying customers. The prices may vary according to the pharmacies you buy. You can purchase Videx for a lower price if you qualify for discount offers, rebates, and copays.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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