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Treximet (Sumatriptan/Naproxen)
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Treximet (sumatriptan/naproxen) is an oral tablet used to treat migraines in adults and children 12 years of age and older. Its active ingredient, sumatriptan, belongs to the class of drugs called triptans, which act as selective serotonin receptor agonists, while naproxen is a non-steroidal anti-inflammatory drug.
This combination is effective in relieving migraine symptoms as well as headache, sensitivity to light and sound, and nausea. However, Treximet is only used when a migraine has already started and does not prevent future migraine attacks or reduce the frequency of attacks.
Treximet works because its active ingredients, such as sumatriptan, bind to certain receptors in the brain. This helps reduce migraine pain by constricting blood vessels in the head and blocking the nerve signals that cause pain.
The other component of Treximet, naproxen, works by blocking the production of prostaglandins, which are substances in the body that cause inflammation and increase pain sensitivity . By reducing these prostaglandins, naproxen helps to reduce pain and inflammation, which helps to relieve migraine symptoms.
It is a very effective treatment option, especially when other migraine medications have not worked, but it is not recommended for the treatment of other types of headaches, such as cluster headaches or headaches caused by loss of movement on one side of the body.
Treximet Precautions and Warnings
Treximet, as a migraine medication, comes with important FDA warnings about possible serious risks, including serious cardiovascular and digestive problems.
It is important to note that it should not be used if you are planning coronary artery bypass surgery. In addition, it has several contraindications, which means that it should not be prescribed if you have certain conditions, such as previous heart disease, uncontrolled hypertension, severe kidney or liver problems, aspirin-exacerbated asthma, among others. Also, if you have recently taken other medications such as ergotamine or monoamine oxidase inhibitors.
Always remember that before taking Treximet you should talk to your doctor about your medical history as other conditions such as anemia, circulation problems, or coronary artery disease require careful evaluation. In this regard, Treximet may cause serious side effects such as serotonin syndrome, as well as severe skin reactions or headaches from overuse of the drug.
Treximet Side Effects
Treximet may cause some side effects, some more common than others. These side effects may be temporary and last from a few days to weeks, but if they last longer or continue to cause discomfort or worsen, be sure to talk to your doctor or pharmacist.
Mild Side Effects
- Drowsiness
- Dizziness
- Feeling of nausea
- Indigestion
- Dry mouth
- Numbness or tingling in hands or feet
- Pain or pressure in your jaw, throat, or neck
Moderate Side Effects
- Headache from overuse of the medicine (rebound headache)
- Severe skin reactions (such as exfoliative dermatitis, and Stevens-Johnson syndrome)
- Circulation problems (pale fingers, weakness or numbness in one part of the body)
- Kidney problems (decreased urination, fluid retention in legs or feet)
- Increased blood pressure
Serious Side Effects:
- Serotonergic syndrome (changes in blood pressure, tachycardia, hallucinations)
- Severe cardiovascular problems (heart attack, stroke)
- Serious digestive problems (gastrointestinal bleeding, ulcers)
- Heart failure
- Seizures
- Severe skin reactions (rash, hives)
- Liver problems (jaundice, flu-like symptoms)
- High potassium levels
Allergic Reactions
If you experience rash, itching, redness, swelling of the eyelids, lips, hands, or feet, or difficulty breathing due to swelling of the mouth, tongue, or throat, it is important to contact a doctor immediately.
Drug Interaction with Treximet
When taking Treximet concurrently with other medications, it is important to be aware of possible interactions and side effects that may occur.
- Avoid taking it with ibuprofen as it may increase the risk of side effects such as bleeding, ulcers, and tears in the stomach or intestines.
- Also do not take it with aspirin or other salicylates such as Nuprin Backache Caplet, Kaopectate, KneeRelief, Pamprin Cramp Formula, Pepto-Bismol, Tricosal, and Trilisate.
- Not recommended to be taken with certain antidepressants may cause easy bruising or bleeding.
- You must inform your doctor if you are taking medications such as cyclosporine, lithium, methotrexate, heart or blood pressure medications, including diuretics.
- Do not take anticoagulants at the same time, such as warfarin (Coumadin, Jantoven).
- Tell your doctor if you are taking steroids such as prednisone or dexamethasone.
Strengths and Dosages of Treximet
Treximet is available in two presentations:
- Coated tablets of 10 mg sumatriptan/60 mg naproxen sodium
- Tablets containing 85 mg sumatriptan/500 mg naproxen sodium
How to Take Treximent
Take one tablet with or without food whenever you have migraine headaches. If the pain persists, consult your doctor before taking a second tablet, which should be taken at least two hours after the first.
Do not take more than two tablets in 24 hours and do not treat more than five migraines per month (or two if you are between 12 and 17 years of age). The starting dose is one 85/500 mg tablet for adults and one 10/60 mg tablet for children 12 years and older.
Cost of Treximet in America
The price of Treximet can vary widely depending on various factors, including the manufacturer, the country of origin, and the pharmacy where it’s purchased. The cost of the (500 mg-85 mg) oral tablets is around $1,338 for a supply of 9 tablets. In some cases, prices may also vary depending on insurance coverage, discount programs, or pharmacy-specific promotions. And for a better price, find it here at MyRx Outlet.
Treximet Alternatives
| Treximet
(naproxen / sumatriptan) |
Sumatriptan | Imitrex (sumatriptan) |
| Prescription only | Prescription only | Prescription only |
| For Migraine. Treximet may also be used for purposes not listed in this medication guide. | Sumatriptan may be used to quickly relieve the symptoms of a migraine but may not be suitable for everyone including those with pre-existing cardiovascular conditions. | For Cluster Headaches, Migraine. Imitrex may also be used for purposes not listed in this medication guide. |
| For Cluster Headaches, Migraine, New Daily Persistent Headaches, and Cyclic Vomiting Syndrome. | ||
| Ratings | Ratings | Ratings |
| Treximet has an average rating of 9.1 out of 10 from a total of 92 ratings on Drugs.com. 91% of reviewers reported a positive effect, while 4% reported a negative effect. | Sumatriptan has an average rating of 7.7 out of 10 from a total of 543 ratings on Drugs.com. 71% of reviewers reported a positive effect, while 17% reported a negative effect. | Imitrex has an average rating of 7.8 out of 10 from a total of 205 ratings on Drugs.com. 71% of reviewers reported a positive effect, while 14% reported a negative effect. |
Treximet FAQs
How should I store Treximet?
Store this product at room temperature at 25°C (77°F); also permitting 15°-30°C (59°-86°F), and in a safe place away from excessive heat and direct sunlight.
Be sure to dispose of any leftover medication safely by not flushing it down the toilet or pouring it down the drain.
Keep this medicine and all medicines out of the reach of children and pets.
Can I get other forms of this medicine?
You can get Treximet in two different dosages as well as in generic versions:
- An 85/500 mg with 119 mg sumatriptan succinate equivalent to 85 mg sumatriptan and 500 mg naproxen sodium, presented as blue film-coated tablets and in bottles of 9 tablets with desiccant.
- An 10/60 mg with 14 mg sumatriptan succinate equivalent to 10 mg sumatriptan and 60 mg naproxen sodium, also presented as light blue film-coated tablets and in bottles of 9 tablets with desiccant.
What happens if you take an overdose of Treximet?
In case of an overdose of this medicine, seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Can I take Treximet if I have asthma? If so, what side effects should I expect?
Because it contains naproxen, this medication may worsen asthma symptoms in people with aspirin-exacerbated respiratory disease.
Symptoms of this condition include nasal congestion, sinus pain, sneezing, coughing, chest tightness, flushing, rash, abdominal pain, and vomiting.
People with AERD often have asthma, sinusitis, nasal polyps, and sensitivity to aspirin or NSAIDs. Tell your doctor, who will not prescribe Treximet.
If you have asthma and you develop these symptoms while taking Treximet, consult your doctor immediately.
What happens if you forget to use Treximet?
This will not be a problem since Treximet is taken only when needed, it does not have a daily dosing schedule. It is important not to take more than 2 tablets in 24 hours.
Can I drink alcohol while taking Treximet?
You should not combine Treximet with alcohol. One of the active ingredients in Treximet is naproxen (the other is sumatriptan) and combining it with alcohol could cause ulcers (sores) and bleeding in your stomach and intestines. Drinking alcohol during treatment with Treximet may irritate your digestive tract. Tell your doctor immediately if you have any symptoms of bleeding in your digestive tract, including bright red or brownish-colored vomit and bloody or black stools.
Should I continue to use Treximet even if I feel better?
As this is a single dose, the treatment must be completed in its entirety.
Our Guarantee For Buying Treximet From A Canadian Pharmacy Partner
At MyRx Outlet, we are committed to delivering safe, high-quality medications that you can trust. We adhere to strict regulations in every country we operate in, ensuring that your order is handled by a licensed Canadian pharmacy or a trusted partner overseas. Each medication has been legally approved by Health Canada or other respected authorities. To purchase Treximet at a discounted rate, call 1-888-551-2467.
IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.
