Synvisc, a brand name for Hylan G-F 20, is a viscosupplement injection used to relieve pain and improve joint function in individuals with osteoarthritis. It falls under hyaluronic acid injections, designed to supplement the natural synovial fluid in the joints and provide long-lasting relief.

How Does Synvisc Work?

Synvisc supplements the synovial fluid in the joints, acting as a lubricant and shock absorber. In osteoarthritis, the synovial fluid’s natural properties are diminished, contributing to joint pain and stiffness.

Synvisc contains hyaluronic acid, a substance that closely resembles the synovial fluid. When injected into the affected joint, Synvisc enhances lubrication, reduces friction, and helps cushion the joint, alleviating pain and improving mobility.

Precautions and Warnings of Synvisc

Before considering Synvisc treatment, please be aware of the following precautions and warnings:

  • Allergies: If you have known allergies to hyaluronic acid or avian proteins, avoid Synvisc.
  • Infection at the Injection Site: Synvisc should not be administered in the presence of skin diseases or infections around the site.
  • Pregnancy and Breastfeeding: Limited data are available on the use of Synvisc during pregnancy and breastfeeding, so it is recommended to consult with your doctor before use for a tailored, personalized recommendation.

Side Effects of Synvisc

In the case of persistent or severe side effects, medical attention should be sought promptly. If the symptoms persist beyond a week or become more severe, you should contact your healthcare provider.

Synvisc injections may lead to specific side effects, including:

  • Pain at the Injection Site: Some individuals may experience temporary pain, swelling, or warmth at the injection site.
  • Joint Stiffness: Transient stiffness in the treated joint may occur following the injection.
  • Minor Skin Reactions: Redness or bruising at the injection site is possible but typically resolves independently.
  • Signs of Infection: Watch out for signs of infection such as persistent warmth, redness, increased pain, or drainage from the injection site. If you notice any of these signs, seek medical attention promptly.
  • Severe or Prolonged Pain: If you experience severe or prolonged pain that is not improving, consult your healthcare provider sooner rather than later.

Drug Interactions with Synvisc

Synvisc (Hylan G-F 20) is administered through intra-articular injections, which minimizes the potential for systemic drug interactions.

That being said, it is still crucial to communicate all medications, including over-the-counter drugs, supplements, and herbal products, to your doctor to ensure a comprehensive understanding of your treatment context.

Although direct drug interactions with Synvisc are uncommon, certain medications like anticoagulants or blood thinners (such as Eliquis or Xarelto) may pose a theoretical risk due to the injection procedure. One notable consideration is the potential impact on the injection site, particularly in individuals taking medications affecting blood clotting. This underscores the importance of a thorough discussion with your healthcare provider to see any potential interactions and make informed decisions about your treatment plan. Please always follow your healthcare provider’s guidance and report any unusual symptoms as soon as possible.

Strengths and Dosages of Synvisc

Synvisc is available in a single-dose syringe, and the recommended treatment typically involves a series of injections. The specific dosage and frequency of injections depend on the severity of osteoarthritis and your doctor’s recommendations, but the following is a general guide.

Synvisc Single Dose1 6 ml injection


Synvisc-One Single Dose1 6 ml injection


Synvisc Triple DoseThree 2 mL injections


The main differences between Synvisc, Synvisc-One, and Synvisc Triple lie in their formulations and administration:

Synvisc: Synvisc is typically administered as three injections, each containing 2 mL of the viscosupplement. The injections are usually given at weekly intervals.

Synvisc-One: Synvisc-One is a single-dose formulation that comes in one pre-filled syringe with 6 mL of Hylan G-F 20. This eliminates the need for multiple injections over several weeks, as a complete treatment course is administered in a single session.

Synvisc Triple: Synvisc Triple is a treatment regimen where three separate injections of Synvisc (2 mL each) are administered. This term is used to describe the three-injection course of Synvisc.

Essentially, the primary distinction lies in the number of injections and the volume of the viscosupplement in each syringe. Synvisc requires three separate injections, while Synvisc-One provides the full course in a single injection. The term “Synvisc Triple” essentially refers to the traditional three-injection course of Synvisc. The choice between these formulations is typically based on your doctor’s recommendation and your preferences.

Synvisc Alternatives

Patients should consult with their healthcare provider to determine the most suitable treatment option based on their specific condition and medical history.

While Synvisc is a commonly used viscosupplement for osteoarthritis, alternatives may include:

  • Hyalgan (Sodium Hyaluronate): Another hyaluronic acid injection used for similar purposes.
  • Corticosteroid Injections: In some cases, healthcare providers may recommend corticosteroid injections for short-term relief of osteoarthritis symptoms.

FAQs of Synvisc

How long does the pain relief from Synvisc last?

The duration of pain relief varies, but some individuals experience relief for several months.

How many injections are typically needed?

A common treatment regimen involves three injections given at weekly intervals.

Can Synvisc be used in all joints?

Synvisc is commonly used in the knee joint and may be used in other joints based on the healthcare provider’s recommendation.

Are there any specific restrictions after receiving Synvisc injections?

Patients are typically advised to avoid strenuous activities for a short period after the injections, as recommended by their healthcare provider.

Can Synvisc be used for other types of arthritis?

Synvisc is specifically approved for osteoarthritis and may not be suitable for other forms of arthritis.

Can I receive Synvisc injections if I have allergies?

Individuals with allergies to hyaluronic acid or avian proteins should avoid Synvisc. It is crucial to inform your healthcare provider about any allergies before treatment.

How much does Synvisc cost in America?

The cost of Synvisc in America varies based on factors such as the number of injections needed and the location, but on average, a course of Synvisc injections can range from $500 to $2,500. Prices may differ between healthcare providers and regions.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

Product was successfully added to your cart!