Monovisc (Sodium Hyaluronate)
Monovisc is a prescription-use knee injection (administered by a qualified healthcare professional) used to help relieve pain from osteoarthritis of the knee. It is a single-injection viscosupplement for patients who have not had enough relief from conservative non-drug therapy or simple pain relievers such as acetaminophen.
We only dispense medications with a valid prescription from a licensed prescriber.
All prescriptions are reviewed and verified before dispensing. Orders may be delayed or declined if prescription details are missing, do not match the patient information on file, appear altered, or are expired. We may also refuse service if we believe an order is intended for resale or redistribution.
What You Receive
- Monovisc in sealed manufacturer packaging
- Personalized prescription instructions based on your prescriber’s directions
- Medication information leaflet provided by the manufacturer
- Itemized invoice detailing your order
- Rx Required
- Delivered Within 4-7 Days
- Medication From Canada
From $449.95
Shipping & Delivery
- Shipped from licensed pharmacy partners
- Tracking information is provided once your order ships
Delivery times may vary based on location and prescription verification.
This page is for general information only and is not medical advice. For medical questions, please speak with your prescriber. See Sources & Methodology for how this information is reviewed and referenced.
Monovisc Key Facts
What Monovisc is
Monovisc is a sterile, single-use, high molecular weight hyaluronan (hyaluronic acid) viscosupplement in a prefilled syringe. It is derived from bacterial fermentation and is injected directly into the knee joint by a trained medical professional.
What it’s used for
Monovisc is indicated for treatment of pain in osteoarthritis of the knee in patients who have not responded adequately to conservative non-pharmacologic therapy or simple analgesics.
How it works
Monovisc supplements joint fluid with hyaluronan, which helps support lubrication and shock absorption in the knee joint. In osteoarthritis, natural hyaluronan may be reduced or poorer in quality, and this injection is used to help improve knee pain in appropriate patients.
Monovisc Safety Overview
Monovisc is a clinician-administered knee injection, so screening for allergies, infection risk, and injection-site issues is important before treatment.
Monovisc Warnings & Precautions
The labeling of Monovisc also includes handling and technique precautions because this is a sterile single-use product.
Do not use Monovisc if:
- You have a known allergy to hyaluronate preparations or gram positive bacterial proteins
- You have an infection or skin disease in the area of the injection site or joint
- You have an infection or skin disease in the area of the injection site or joint
Key warnings to know
- Monovisc should be injected by a trained medical professional using strict aseptic technique
- Quaternary ammonium salt disinfectants should not be used for skin preparation
- Temporary knee pain, swelling, or inflammation flare can occur after injection
- The syringe is single use only and should not be used if the package is opened or damaged
- Safety and effectiveness have not been established for joints other than the knee, in pregnancy, during nursing, in pediatric patients, or for more than one treatment course
Side Effects and When to Get Help
Most side effects reported with Monovisc are local knee or injection-site reactions and are often temporary. Patients should contact their healthcare professional if symptoms appear after the injection or if symptoms worsen.
Possible side effects may include
- Joint pain or knee pain
- Joint swelling or injection site pain
- Injection area irritation such as warmth, redness, bruising, rash, or itching
- Mild achiness or discomfort after the injection
- Less common reactions such as headache, dizziness, nausea, chills, muscle cramps, swelling, or malaise
Get urgent help right away for
- Signs of a serious allergic reaction such as trouble breathing, swelling, or hives
- Severe or rapidly worsening knee pain, swelling, heat, or redness after injection
- Symptoms that do not improve or feel severe after the injection
- Any serious or unusual reaction after the injection procedure
Interactions
Monovisc is not known for typical systemic drug-drug interactions, but there is an important administration-related compatibility warning in the labeling. Your prescriber should also review your allergies, bleeding history, and other knee treatments before injection.
Interactions you should discuss with your prescriber include
- Skin preparation products that contain quaternary ammonium salts
- Blood thinners or bleeding concerns, especially if you have a bleeding disorder
- Other knee injections or procedures planned around the same time
- Allergy history, including reactions to hyaluronate products or gram positive bacterial proteins
- All prescription medicines, otc medicines, vitamins, and supplements
Monovisc Drug Facts
| Category | Details |
|---|---|
| Brand Name | Monovisc |
| Drug Class | Viscosupplement (cross-linked hyaluronan) |
| Indication | Knee osteoarthritis pain after inadequate response to conservative therapy/simple analgesics |
| Dosage Forms | Prefilled single-use syringe for intra-articular knee injection |
| Strengths | 88 mg/4 mL |
| Administration Timing | Single knee injection by a healthcare professional |
| Key warnings | Allergy to hyaluronate/gram positive bacterial proteins; infection/skin disease at site/joint; systemic bleeding disorders; inflammation flare can occur |
| Storage | Store in original package at room temperature below 25°C (77°F); do not freeze |
| Missed Dose | Clinic-administered injection; contact your clinic/prescriber to reschedule |
| Alternatives | Orthovisc, corticosteroid knee injection, other knee viscosupplements (prescriber-selected) |
Helpful Information
How To Buy Monovisc Online
1
Select Your Prescribed Monovisc Dosage & Strength
Choose the strength and quantity that matches your prescription, then add it to your cart. Orders are limited to a 90-day supply per fill.
2
Complete Checkout
Ensure your shipping and contact information is correct so your order can be processed without delays.
3
Submit Your Monovisc Prescription
Upload your prescription at checkout. If you need a transfer, provide your prescriber or current pharmacy details and we will request it on your behalf.
Prescription & Dispensing Standards
- Prescription required for all orders and reviewed for pharmacy and regulatory compliance
- Dispensed by licensed pharmacy partners
- Orders are held if information is missing, unclear, or does not match.
- No substitutions without prescriber approval, and no controlled substances.
Our Guarantee
At MyRx Outlet, we are committed to delivering safe, high-quality medications that you can trust. We adhere to strict regulations in every country we operate in, ensuring that your order is handled by a licensed Canadian pharmacy or a trusted partner overseas. Each medication has been legally approved by Health Canada or other respected authorities. To purchase Monovisc at a discounted rate, call 1-888-551-2467.
FAQs
What is Monovisc used for?
Monovisc is used to treat pain from osteoarthritis of the knee in patients who have not had enough relief from conservative non-drug treatment or simple pain relievers such as acetaminophen.
How is Monovisc given?
A qualified healthcare professional gives Monovisc as a single injection directly into the knee joint. The patient information describes a single injection of 88 mg/4 mL into the knee.
What should I avoid after a Monovisc injection?
The patient information recommends avoiding strenuous or prolonged weight-bearing activities (for example jogging, tennis, heavy lifting, or standing for long periods) for 48 hours after the injection.
What are the most common side effects of Monovisc?
The most commonly reported adverse events include joint pain (arthralgia), joint swelling, and injection site pain. Other reactions such as rash, headache, dizziness, itching, nausea, and malaise have also been reported.
Who should not get Monovisc?
Monovisc should not be used in people with certain allergies (including hyaluronate products or gram positive bacterial proteins), infection or skin disease near the injection site/joint, or known systemic bleeding disorders.
Ordering & Prescription FAQs
Do I need a prescription?
Yes, a prescription is required. Refills depend on what your prescriber authorizes.
How do I submit my prescription?
You can upload it through our Upload Prescription page, email it to info@myrxoutlet.com, or fax it to 1-888-230-1245. If you need a prescription transfer, just let us know at checkout and include your pharmacy or prescriber contact details.
When is my payment processed?
Your payment is processed only after your prescription and order have been reviewed and approved by our licensed pharmacy team. Once everything is confirmed, we’ll process payment and prepare your order for shipping.
What happens if my prescription can’t be verified?
Your order may be placed on hold or declined if prescription details are missing, don’t match, are expired, or can’t be confirmed.
Sources
Anika Instructions for Use, MONOVISC (USA IFU, AML 500-299 REV-E 2023-07)
https://www.anikaifu.com/wp-content/uploads/2023/12/Monovisc-USA-AML-500-299-E.pdf
FDA Information for Prescribers, MONOVISC High Molecular Weight Hyaluronan (PMA P090031)
https://www.accessdata.fda.gov/cdrh_docs/pdf9/p090031c.pdf
FDA Patient Information, MONOVISC High Molecular Weight Hyaluronan (PMA P090031)
https://www.accessdata.fda.gov/cdrh_docs/pdf9/P090031d.pdf