The medication Feldene is also referred to as piroxicam and is used to cure symptoms of osteoarthritis and rheumatoid arthritis, including reducing swelling and treating pain.

Some doctors may also prescribe it to relieve pain caused by other conditions. It is particularly important to consult your doctor before using Feldene to cure pain resulting from chronic conditions to avoid side effects.

How Does Feldene Work?

Feldene works by inhibiting the enzyme cyclooxygenases (COX), which plays a vital role in producing prostaglandins. Prostaglandins are responsible for several body responses including fever, pain, and inflammation. There are two types of COX namely:

  • COX-1: It is mostly found in body tissues in the gastrointestinal tract. COX-1’s main role is to maintain and protect the lining of the stomach and intestines from digestive juices.
  • COX-2: Majorly concerned with inflammation, pain, and fever.

When Feldene blocks the COX enzyme, it reduces the production of prostaglandins in the body hence an overall reduction in inflammation, pain, and fever.

Forms of Feldene

Feldene is available in two forms for easy administration. These include:


The medication is taken orally to reduce pain and inflammation in conditions like arthritis. Feldene capsules come in different strengths, namely:

  • 10 mg maroon and blue capsule
  • 20 mg maroon capsule

It is advisable to start with the lowest effective dosage and adjust the dosage based on individual needs and as prescribed by your doctor.


Feldene is also available as a clear, pale yellow gel. The gel comes in 25-gram or 50-gram tubes.

Ideally, Feldene 0.5% gel is applied directly to affected areas to relieve pain and inflammation that may have been caused by sprains. The skin on the affected area should be healthy with no open wounds, rashes, or infections.

Precautions and Warnings of Feldene

Patients using Feldene should be mindful of the precautions and warnings associated with the medication. If not used appropriately, Feldene can cause serious health risks. Here are precautions and warnings to note:

  • Skin Reactions: Patients using Feldene gel, should be monitored closely for any skin reactions after applying the medicine, as it can cause progressive skin rash often accompanied by blisters or mucosal lesions. In case of any skin reaction, Feldene should be discontinued immediately.
  • Allergic Reactions: Before taking the medication, inform your doctor if you are allergic to medicines that belong to nonsteroidal anti-inflammatory drugs to prevent potential allergies that could worsen side effects like vomiting and nausea.
  • Pregnancy and Lactation: Avoid using Feldene if you are pregnant or planning to get pregnant because it can increase the risk of spontaneous abortion during the first two trimesters of pregnancy. Feldene may also pass to the breast milk, causing risks to nursing infants.
  • Gastrointestinal Risks: Using Feldene may increase the risk of a patient having serious gastrointestinal diseases such as ulcers, bleeding, and perforations. As such, patients having a medical history of gastrointestinal issues should use the medication with caution.
  • Cardiovascular Diseases: Feldene may increase the risk of developing cardiovascular diseases such as stroke and heart attack, especially in patients with pre-existing cardiovascular conditions.
  • Hypertension: The use of Feldene can result in a new development of blood pressure or exacerbation of existing blood pressure. Both scenarios can lead to an increased risk of cardiovascular diseases.
  • Elderly people: Elderly patients are most vulnerable to developing adverse effects of the drug like bleeding, hypertension, and cardiovascular disease. Therefore, they should be monitored closely while using the medication.

Feldene Side Effects

Like all medicines, Feldene can cause side effects although not every patient experiences them. In case you experience the side effects, inform your doctor immediately and stop using the medication.

Common Side Effects

These are usually mild side effects that go away on their own. You should, however, seek medical intervention if they persist or become severe.

  • Vomiting
  • Drowsiness
  • Constipation
  • Headache
  • Itching
  • Skin rash

Severe Side Effects

You should contact a health practitioner if you experience any of these side effects:

  • Skin rashes, including peeling of the skin.
  • Abnormalities in the blood such as decreased hemoglobin
  • Constriction of the muscle lining the airways of the lungs
  • Inflamed pancreas which may lead to severe pain in the upper abdomen or back
  • Inflammation of the stomach lining
  • Stomach ulcers

Interactions With Feldene

Feldene can interact with different medications which can prevent the effectiveness of the drug. Certain interactions can also lead to potential side effects like hypertension, ulcers, and bleeding.

Drug Interaction
Anticoagulants e.g., Warfarin Concurrent use of anticoagulants and Feldene can cause enhanced bleeding and gastrointestinal ulceration.
Lithium The interaction of Feldene and lithium decreases renal clearance. This increases lithium concentrations in blood leading to lithium toxicity, which also affects the central nervous system.
Alcohol Combining alcohol with Feldene results in an increased risk of central nervous system depression, which causes gastrointestinal irritation and increases the risk of bleeding.
Diuretics Causes reduced blood pressure control and compromised diuretic efficacy.
Cardiac glycoside Administering Feldene concomitantly with cardiac glycoside increases the risk of having cardiac failure and plasma glycoside levels.
Corticosteroids e.g., Prednisone Increases the risk of gastrointestinal ulceration or bleeding.

Strengths and Dosages of Feldene

The dosage and strength of the medicine will depend on factors like your age, the condition you are suffering from, the severity of the condition, other medical conditions, and how you will respond to the initial dose.


Minimum dosage (once daily)


Maximum Dosage (twice daily)








You should take Feldene orally once or twice daily with a full glass of water while taking the medication. You can take the drug with food if it upsets your stomach.

If you miss a dose, take it as soon as you remember. Avoid taking two doses at a time as it can result in potential side effects.

Feldene is not recommended for pediatric use. The safety and efficacy of Feldene for patients under the age of 18 years have not been determined.

For the 0.5% Feldene gel, patients should apply a 1-gram dose to the affected area and rub in, leaving no residual. Do this three to four times a day to experience Feldene’s effects.

Alternatives of Feldene

The alternative drug will be offered to a patient depending on the condition you are suffering from, and how well you tolerate a certain medication. Consult a doctor if you want to exchange the medication, to avoid possible interactions.

There are types of drugs that can be used in a similar way as Feldene. They include:

  • Methotrexate– It is used in the treatment of rheumatoid arthritis. The drug can also be used to treat cancers such as brain tumors, breast cancer, and cervical cancer.
  • Sulfasalazine– Effective for treating ulcerative colitis and rheumatoid arthritis in case Feldene is not available.
  • Other drugs– Certain drugs that work similarly to Feldene include prednisone, Celebrex, Remicade, and Plaquenil.

FAQs of Feldene

How should I store Feldene?

The drug should be stored at room temperature away from direct heat, moisture, and light. Keep it out of reach of children and pets. Do not keep expired medication.

What drug should I avoid when taking Feldene?

Avoid the consumption of alcohol when taking the medication as it may increase the risk of stomach bleeding. Also, discuss drug interactions with your doctor before use.

What are the side effects of Feldene?

Common side effects include swelling, anorexia, abdominal pain, ulcers, dizziness, and drowsiness. However, not all patients using the drug will experience these side effects.

What precautions should be taken when taking Feldene?

Avoid using the drug before or after heart surgery. This may increase the risk of a patient having a fatal heart attack or stroke which can lead to chronic paralysis.

Can Feldene be taken with food?

Yes. Take the medication with food, milk, or any antiacid to prevent stomach upset and reduce the chances of bleeding in the stomach or ulcerations.

Does Feldene make you feel sleepy?

Yes. Feldene can make you feel dizzy and drowsy or headache. In case any of the symptoms persist seek immediate medical assistance.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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