Inlyta is a kinase inhibitor used to treat renal cell carcinoma (RCC), a common type of kidney cancer. For the most part, Inlyta is prescribed for advanced kidney cancer or one that has spread to the rest of the body, mainly when other treatments have failed.

Renal cell carcinoma is the most prevalent type of kidney cancer that affects 90% of people who have kidney cancer. RCC may start as a single tumor in one kidney but could grow to several tumors in one or both kidneys.

While renal cell carcinoma can be noticed early in some patients, others may fail to recognize it until it metastasizes. Inlyta is used to treat advanced kidney cancer when other treatments have failed.

Typically, this medication is administered to adults and is taken twice daily during treatment.

How Does Inlyta Work?

Inlyta contains the active ingredient axitinib, which is responsible for its function. Being a kinase inhibitor, Inlyta works by preventing the formation of blood vessels that supply the tumor with blood.

Since cancer cells rely on the blood supply to acquire nutrients, cutting its supply deprives the cells of nutrients, which slows their growth.

Precautions and Warnings of Inlyta

Before starting Inlyta, you should be aware of the precautions and warnings associated with the medication. You should inform your doctor about your previous medical conditions and the medications you are currently taking to ensure safe usage.

  • Proteinuria: Inlyta may cause patients to develop proteinuria. If you experience severe or moderate proteinuria when undergoing the treatment, discontinue the medication immediately and seek medical assistance.
  • Hemorrhage: Individuals using Inlyta may experience hemorrhage. Stop using Inlyta if you experience any signs and symptoms of hemorrhage, such as dizziness, rapid heart rate, and unilateral weakness.
  • Cardiovascular Conditions: If you have heart problems that cause difficulty breathing or chest pain, make sure you inform the doctor before starting the medication, as Inlyta may worsen your condition.
  • Wound Healing Complications: Inlyta can slow down the rate of wound healing because it disrupts the signaling pathways essential for healing.
  • Abnormal Bleeding: Using Inlyta may result in side effects such as nosebleeds, coughing blood, and heavy menstrual flow, which may cause you to lose a lot of blood. This can be fatal.
  • Blood Clotting: Inlyta could potentially increase the risk of developing blood clots in your legs, leading to swelling or a blood clot in your lungs that may cause difficulty in breathing or chest pains.
  • Thyroid Dysfunction: The medication may cause the development of thyroid dysfunction, intensifying side effects such as weight changes and fatigue. Patients should be monitored regularly for any thyroid dysfunction.

Inlyta Side Effects

Patients taking Inlyta may have side effects. The common and mild side effects are usually temporary. However, if you experience severe side effects, contact your doctor for medical assistance and guidance.

Common Side Effects

  • Cough, shortness of breath
  • Headache
  • Rash and peeling of the skin on your hands or feet
  • Stomach pain
  • Hoarse voice
  • Feeling weak or tired
  • Decreased or increased appetite

Severe Side Effects

  • Blood in your urine or stool
  • Trouble breathing
  • Seizures
  • Allergic reactions
  • Hair loss
  • Weight gain or loss
  • Muscle and bone pain

Drug Interactions With Inlyta

Inlyta can interact with several medicines, potentially causing an impact on its effectiveness and safety. It is important to be aware of these interactions and consult with your doctor to ensure the safe and effective use of Inlyta alongside other medications.

Drug Interaction
CiprofloxacinCombining ciprofloxacin medication with Inlyta may increase the risk of adverse side effects such as fatigue, hypertension, and gastrointestinal symptoms
RifampinConcurrent use of Inlyta and rifampin (Rifadin) could potentially reduce the concentration of Inlyta in the bloodstream and compromise the efficacy of the medication.
Anticoagulant medicationsThe interaction between Inlyta and anticoagulant drugs such as heparin can lead to an increased risk of bleeding complications.
Calcium blockers like verapamilUsing verapamil while taking Inlyta could elevate the concentration of Inlyta in the blood, possibly resulting in side effects like hypertension or hand-foot syndrome.
PhenytoinPhenytoin (Dilantin) medication can decrease the concentration of Inlyta in the bloodstream. This can potentially lead to decreased therapeutic effects in managing the condition.
RitonavirThe interaction of Inlyta and ritonavir (Norvir) may alter the metabolism of Inlyta affecting its effectiveness and possibly intensifying side effects.

Strengths and Dosages of Inlyta

Your doctor will consider factors like the medications you are currently taking, any potential side effects you might experience while taking Inlyta, and your liver conditions when prescribing Inlyta for you.

In most cases, you will start with a conservative dosage, and then adjust it to find the optimal level for you. The process ensures that the medication achieves the desired effect with minimal side effects.

Inlyta tablets should be swallowed whole and avoid crushing, chewing, or breaking it.

Age Dose Modification    No. of days
 Starting dose Dosage increase  Dosage decrease   
1st increase 2ndincrease 1stdecrease 2nddecrease
Adult5mg7mg10mg3mg2mgTwice per day

Cost of Inlyta in America

The cost of a 180-tablet supply of Inlyta each containing 1mg, usually falls around $21,644. However, this price can fluctuate depending on the pharmacy you purchase the drug.

It is worth noting that the prices are primarily meant for individuals who are paying in cash and may not be applicable if you have medical insurance coverage.

Why is Inlyta so expensive?

Inlyta is expensive because of several factors:

  • Developing Inlyta involves a lot of research, testing, and meeting regulatory requirements, which all cost a significant amount of money. These costs are transferred to the price of the medication.
  • Limited competition and effectiveness of the drug results in higher pricing.
  • Making Inlyta requires advanced manufacturing processes and special facilities, which add to the expenses.
  • Companies spend lots of money on distributing and promoting the medication which affects the overall cost.

Inlyta Alternatives

Inlyta has alternative medications that offer diverse approaches to treat cancer by targeting specific pathways involved in tumor growth and angiogenesis. Here are some alternative medications to Inlyta.

  • Nexavar: This medication is a multi-kinase inhibitor that targets tumor proliferation by inhibiting the receptors.
  • Sutent: It inhibits multiple tyrosine kinases including the ones involved in tumor growth. This helps prevent the growth and spread of cancer cells
  • Cabometyx: This drug blocks the tyrosine kinase enzyme essential for tumor growth and the formation of new blood cells that feed the tumor. This helps in stopping the tumor from getting the resources it needs to grow and spread.
  • Other Medications: Other alternative medications include Lemvima, Votrient, Afinitor, Ketruda, Opdivo, and Nivolumab.

FAQs of Inlyta

How long does Inlyta stay in your system?

Typically, Inlyta has a half-life of about 2.5-6.1 hours.

What is Inlyta used for?

Inlyta is used in the treatment of advanced renal cell carcinoma a type of kidney cancer. It is particularly given to patients who have previously received systemic therapy for renal cell carcinoma.

How does Inlyta work?

The medication works by inhibiting VEGF receptors responsible for tumor growth and blood vessel formation. By blocking these receptors, Inlyta cuts blood supply to cancer cells thereby slowing down the progression of the cancer.

What should I avoid while on Inlyta?

Avoid eating grapefruit or drinking grapefruit juice because it can lead to the build-up of Inlyta in your system, which increases the chances of experiencing severe side effects.

When taking Inlyta what are the chances of getting hypothyroidism?

There’s a high risk of getting hypothyroidism when using Inlyta. Hypothyroidism is usually a predictive marker of Inlyta’s therapeutic effects.

Can I take alcohol while on Inlyta?

No. Consuming alcohol while undergoing the treatment of Inlyta can increase the likelihood of liver damage since both alcohol and Inlyta impact liver function.

What are the possible side effects of Inlyta?

Possible side effects of Inlyta include headache, chest pains, trouble talking, stomach pain, pain in your arms, neck, and jaw, and feeling weak or tired.

Is there a generic of Inlyta?

Inlyta is solely available as a brand-name drug, with no generic version currently on the market. This also makes it expensive.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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