Tivicay is classified as an integrase strand transfer inhibitor (INSTI). HIV (human immunodeficiency virus) cannot multiply in your body when you take this medicine as an antiviral medicine. Together with other antivirals, Tivicay treats HIV, the virus that causes acquired immunodeficiency syndrome (AIDS). It inhibits the activity of the integrase enzyme, which is crucial for HIV replication.

Tivicay inhibits the integrase enzyme through its mechanism of action. As a result of Integrase, viral DNA can be integrated into the DNA of the host cell. By inhibiting this crucial step, Tivicay helps your immune system work more efficiently by decreasing the amount of HIV in your body. By doing this, you reduce your chances of developing HIV complications (such as new infections and cancer) and improve your quality of life.

Tivicay does not cure HIV or AIDS. Keep taking all HIV medications exactly as prescribed by your doctor to decrease your risk of spreading HIV disease to others. As directed by your doctor, use an effective barrier method (latex or polyurethane condoms/dental dams) during sexual activity. Items that may have come into contact with blood or other body fluids should not be shared (such as needles/syringes, toothbrushes, and razors). For more information, talk to your doctor or contact one of our customer service agents, who can set you up with a free pharmacist consultation.

Warnings and Precautions

ivicay is generally well-tolerated, but there are specific warnings and precautions you should be aware of:

Birth Control and Pregnancy

Tivicay may reduce the effectiveness of hormonal birth control methods. If you’re planning to conceive or are already pregnant, it’s essential to consult your healthcare provider before starting Tivicay. They will evaluate the potential risks and benefits to determine the most appropriate course of action.

Drug Interactions

Tivicay can interact with certain medications, affecting their efficacy or causing adverse effects. Inform your healthcare provider about all the medications and supplements you’re taking, including over-the-counter drugs. This will help them identify any potential interactions and adjust your treatment plan accordingly.

Allergic Reactions

While rare, allergic reactions to Tivicay can occur. If you experience symptoms like rash, fever, or facial swelling, seek medical attention immediately. Your healthcare provider will assess the situation and recommend appropriate steps.

Liver Health

Individuals with pre-existing liver conditions should exercise caution when taking Tivicay. Regular monitoring of liver function is important to ensure the medication is not causing any harm. If you notice symptoms like jaundice or dark urine, contact your healthcare provider promptly.

Immune Reconstitution Inflammatory Syndrome (IRIS)

Some HIV-infected patients, especially those with advanced disease, may experience immune reconstitution inflammatory syndrome upon starting antiretroviral therapy, including Tivicay. This occurs as the immune system begins to recover and responds to previously hidden infections. It’s crucial to stay in close contact with your healthcare provider if you notice any unusual symptoms.

Pediatric Use

Tivicay can be prescribed to pediatric patients, but the dosing and usage guidelines differ from those for adults. If your child is prescribed Tivicay, ensure you follow the prescribed instructions closely and communicate any concerns to your healthcare provider.

Side Effects

Tivicay is not without its side effects. Understanding these side effects is crucial for individuals who are prescribed this medication to make informed decisions about their health. Please note this is not a full list of the side effects that can occur with this medication. If you are experiencing side effects, please reach out to your prescriber immediately.

Common Side Effects

When it comes to Tivicay, some side effects are more commonly observed. These effects are often mild and tend to subside as your body adjusts to the medication. Common side effects include:

  • Headache and Nausea: Among the common side effects of Tivicay, individuals might experience mild headaches and occasional nausea. These reactions are often transient and tend to subside as the body adjusts to the medication.
  • Insomnia: Tivicay’s impact on sleep patterns can vary. While some individuals might experience difficulty sleeping, others might feel unusually drowsy. Establishing a consistent sleep routine may help regulate these effects.
  • Fatigue: Feeling tired or fatigued is a common occurrence when starting Tivicay. This fatigue might be a result of the body’s response to the new medication, and it’s usually temporary.

Rare Side Effects

While less frequent, certain side effects of Tivicay warrant attention due to their potential impact on your well-being. These include:

  • Allergic Reactions: While rare, allergic reactions to Tivicay can occur. Symptoms might include skin rashes, itching, swelling of the face or throat, and difficulty breathing. If any of these signs appear, immediate medical attention is essential.
  • Liver Issues: In some cases, Tivicay can lead to elevated liver enzymes. Regular monitoring is crucial to ensure that the medication is not adversely affecting liver function.
  • Mood Changes: There have been rare instances of mood swings or depressive episodes associated with Tivicay. Individuals with a history of mental health concerns should be cautious and communicate any changes to their healthcare provider.
  • Elevated Liver Enzymes: Monitoring liver function is crucial during Tivicay treatment. Elevated liver enzymes can occur, although infrequently. Regular check-ups and adherence to your healthcare provider’s instructions can aid in early detection and management.

Severe Side Effects

While severe side effects are extremely rare, it’s important to be aware of them for your safety and well-being. If you encounter any of the following symptoms, seek medical assistance immediately:

  • Serious Skin Reactions: Severe skin reactions, although rare, can occur with Tivicay usage. Conditions such as Stevens-Johnson syndrome or toxic epidermal necrolysis demand immediate medical intervention.
  • Lactic Acid Buildup: Tivicay use has been linked to lactic acid buildup in the body, a condition known as lactic acidosis. This severe reaction requires immediate medical attention and can lead to life-threatening complications.
  • Immune Reconstitution Inflammatory Syndrome (IRIS): In some cases, Tivicay can lead to an exaggerated immune response known as IRIS. This condition typically occurs when the immune system starts to recover and might present as inflammation in various body parts.
  • Mood Changes and Depression: While uncommon, some individuals might undergo mood swings, depression, or even suicidal thoughts. If you or a loved one notice any abrupt shifts in mental well-being, consult a healthcare professional.


By being aware of potential drug interactions, herbal supplement effects, and food-related impacts, you can take control of your treatment journey. Please note, this list does not cover all interactions with Tivicay. Remember, always consult your healthcare provider before making any changes to your medication or supplement regimen. With the right information and guidance, you can ensure the effectiveness of Tivicay while prioritizing your overall well-being.

Drug Interactions

Tivicay, also known by its generic name dolutegravir, is often prescribed to manage conditions such as HIV. However, it’s crucial to be aware of potential drug interactions to prevent adverse effects. Some common medications that might interact with Tivicay include:

Aluminum Hydroxide

Aluminum hydroxide, commonly found in antacids, can reduce the absorption of dolutegravir. To avoid potential interactions, it’s recommended to take Tivicay at least two hours before or six hours after taking aluminum hydroxide-containing medications.

Calcium Supplements

Calcium supplements, like calcium carbonate and calcium citrate, can interfere with the absorption of dolutegravir. Similar to aluminum hydroxide, it’s advisable to separate the intake of calcium supplements and Tivicay to ensure proper absorption.


Carbamazepine (such as Tegretol), used to treat seizures and certain mood disorders, can decrease the levels of dolutegravir in the body. Regular monitoring and dose adjustments may be necessary when using both medications simultaneously.


Efavirenz, another medication used to manage HIV, can impact the effectiveness of dolutegravir. The combination of these drugs may require dosage adjustments or alternative treatment approaches.


Etravirine, often used in antiretroviral therapy, can influence the levels of dolutegravir in the body. Close monitoring and medical guidance are essential if these medications need to be taken together.


Fosamprenavir, a protease inhibitor used in HIV treatment, can affect the concentration of dolutegravir. Healthcare professionals should be consulted to determine the appropriate dosages.


Fosphenytoin, an anticonvulsant, may alter the effectiveness of dolutegravir. Adjustments in dosages and vigilant monitoring are essential to ensure both medications work optimally.

Iron Supplements

Iron supplements, including ferrous fumarate, ferrous gluconate, and ferrous sulfate, can hinder the absorption of dolutegravir. Taking Tivicay a few hours apart from iron supplements is advisable.


Isoniazid, used to treat tuberculosis, might impact the levels of dolutegravir in the body. Regular medical supervision is necessary to manage these potential interactions.

Magnesium Supplements

Magnesium supplements, such as magnesium hydroxide and magnesium oxide, can affect the absorption of dolutegravir. Maintaining a time gap between the intake of both medications is recommended.


Metformin, a medication for diabetes management, may interact with dolutegravir. Monitoring blood sugar levels and potential dosage adjustments might be needed when using both drugs.

Multiple Vitamins and Minerals with Vitamins A, E

Supplements containing multiple vitamins and minerals, including vitamins A and E, can impact the absorption of dolutegravir. It’s advised to consult a healthcare professional to manage this interaction effectively.

Herbal Interactions

Herbal supplements are often perceived as natural remedies, but they can still interact with prescribed medications like Tivicay. Here are a few herbal supplements to approach with caution:

St. John’s Wort

Known for its mood-enhancing properties, St. John’s Wort can accelerate the breakdown of Tivicay in the body, reducing its effectiveness. If you’re considering using this herbal supplement, discuss it with your healthcare provider to find suitable alternatives.


While Echinacea is commonly used to boost the immune system, it’s important to note that it may interact with Tivicay, potentially affecting your treatment outcomes. Your doctor can guide you on the best course of action.

Ginkgo Biloba

Often taken to enhance cognitive function, Ginkgo Biloba may have interactions with Tivicay. Consulting your healthcare professional can help you make informed decisions about its use.

Food Interactions

Surprisingly, certain foods can also impact the way Tivicay is metabolized in the body. While dietary adjustments are not usually necessary, being aware of these interactions can contribute to your treatment’s success:


This beloved fruit contains compounds that can interfere with the enzymes responsible for breaking down Tivicay. It’s advisable to moderate your consumption of grapefruit or grapefruit juice while on this medication.

High-Fat Meals

Meals rich in high-fat content can slow down the absorption of Tivicay, potentially delaying its effects. While this doesn’t require complete avoidance, consider timing your medication with meals that are lower in fat.

Calcium-Rich Foods

Calcium supplements and dairy products might reduce the absorption of Tivicay. To ensure you’re getting the most out of your medication, discuss your calcium intake with your healthcare provider.


Tivicay tablets come in multiple strengths, allowing for tailored treatment plans. The available strengths include:

10mg Tablets

The 10mg Tivicay tablets are the lowest strength available. They are often used as a starting point for treatment-naive patients or those with specific medical considerations. These tablets provide a foundation for personalized HIV therapy.

25mg Tablets

Tivicay tablets at 25mg offer a mid-range strength that can be suitable for patients who require moderate suppression of the virus. They strike a balance between efficacy and potential side effects, making them a versatile option.

50mg Tablets

At 50mg, Tivicay tablets provide a higher potency for patients who need robust viral suppression. They are commonly prescribed to individuals with advanced HIV infection or those with resistance to other antiretroviral drugs.


By following the recommended dosages and guidelines provided by healthcare professionals, patients can effectively manage their condition and improve their overall well-being.

Dosages for Adults

For adults, the recommended dosage of Tivicay is 50 milligrams (mg) taken orally, once a day. It’s crucial to take the medication consistently around the same time every day to ensure its effectiveness. Tivicay can be taken with or without food, providing flexibility for patients with varying dietary preferences.

Dosages for Pediatric Patients

Pediatric patients, particularly those weighing at least 30 kilograms, can also benefit from Tivicay’s therapeutic effects. The recommended dosage for children is determined based on their body weight. Generally, the dosage is calculated at 1 mg/kg of body weight, up to a maximum of 50 mg, taken once daily.


Tivicay should be stored in a cool and dry environment, away from direct sunlight and heat sources. Ideal storage temperatures typically range between 68°F and 77°F (20°C – 25°C). Avoid storing the medication in places like the bathroom or kitchen, where humidity and temperature fluctuations are common.

The original packaging of Tivicay is designed to provide the necessary protection from light, moisture, and air exposure. Leaving the medication in its original packaging ensures a controlled environment, preserving its integrity.

Whether it’s a bottle or blister pack, always seal the container tightly after each use. This prevents moisture and air from entering and affecting the medication’s stability. If using a bottle, ensure the cap is screwed on securely.

While pill organizers might seem convenient, they can expose Tivicay to varying conditions, including air and light, potentially compromising its effectiveness. It’s best to keep the medication in its original packaging.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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