Seretide is a combination medication containing two active ingredients: salmeterol (a long-acting beta agonist) and fluticasone (a corticosteroid). It is commonly used for the long-term treatment of asthma and chronic obstructive pulmonary disease (COPD).

Asthma and COPD are lung diseases with no known cure. You can prevent severe symptoms of these conditions by making lifestyle changes like stopping smoking and avoiding allergens like pollen and dust.

How Does Seretide Work?

Seretide uses the inhaled corticosteroid fluticasone propionate and salmeterol, a long-acting beta-agonist, to adequately control Asthma and COPD.

Corticosteroids, naturally produced by adrenal glands, control inflammatory responses in the body. In particular, fluticasone in Seretide helps reduce lung inflammation, allowing airways to stay open for easy breathing.

Salmeterol, a long-acting bronchodilator, allows smooth muscles of the bronchi to relax and dilate, allowing for improved airflow and ease of breathing. While the effects of Salmeterol last longer than most other beta two agonists, keeping airways open for about 12 hours, they usually take time to set in. As such, it cannot be used to cure Asthma attacks!

What Forms Does Seretide Come In?

The MDI is usually administered as two inhalations twice daily. At the same time, the Accuhaler is given as one inhalation two times a day to provide a similar dosage of the active ingredient.

Seretide can be administered in two forms, depending on the patient’s needs. These are:

  • Seretide Accuhaler(Dry powder device): 100/50, 250/50
  • Metered Dose Inhaler (MDI): 50/25, 125/25, 250/25

Precautions and Warnings With Seretide

These precautions provide safety information to ensure the mediation is used safely and effectively. Talk to your doctor about how your condition will affect the way you should take the medication.

  • Asthma Severity: Seretide shouldn’t be started when asthma symptoms are significantly worse or are acute. For quick relief from asthma attacks, a short-acting beta agonist (SABA) should be administered instead.
  • Allergic Reactions: Avoid using Seretide if you have ever experienced an allergic reaction to salmeterol, fluticasone, or any excipients.
  • Pregnancy and Breastfeeding: Since there is little information regarding the safety of Seretide during pregnancy and lactation, medical professionals must consider the advantages and disadvantages of the medication before recommending it to a patient who is pregnant or nursing.
  • Bone Health: Lengthy-term use of inhaled corticosteroids such as fluticasone may raise the risk of osteoporosis, especially at high dosages or over lengthy periods.
  • Long-term Use: Corticosteroid use may also raise the chance of developing eye diseases such as cataracts and glaucoma. It is advised that patients receiving prolonged Seretide medication should carry out regular eye exams.
  • Seizure Disorder: Use Seretide with caution if you have a medical history of seizures, as it may increase the risk of worsening this condition.
  • Candida Infections: Before using the medication, it is advisable to undergo an examination for candidiasis, an infection caused by the fungus candida albicans. This is because Seretide may intensify the effects of candidiasis, like thick white clothing on the tongue, leading to a smell in your mouth.
  • Patients with Diabetes, Heart Problems, or High Blood Pressure: You may require extra monitoring from your doctor and dosage adjustments if you have these conditions. Talk with your doctor for the correct dosage recommendations.

Seretide Side Effects

Just like other medications, Seretide can cause side effects to patients using it. They can either be common side effects that are easy to manage or severe side effects that require immediate medical assistance.

Still, not every individual has side effects. If you experience worsening of your side effects, contact the doctor immediately.

Common Side Effects

  • Headache
  • Throat irritation
  • Hoarseness
  • Tremor
  • Nausea
  • Muscle cramps
  • Increased colds for COPD patients
  • Pain in Muscles
  • Reduced Potassium levels in blood, especially for COPD patients

Severe Side Effects

  • Blurred vision
  • Aggression
  • Glaucoma
  • Thinning of the bones
  • Difficulty breathing
  • Tremor
  • Chest Pains
  • Hyperglycemia

Drug Interactions with Seretide

As with any medication, there are potential drug interactions to be aware of when using Seretide with other medicines, vitamins, or foods. Here are some common interactions:

DrugInteraction
Beta-blockersThis may antagonize the bronchodilator effects of salmeterol and increase the risk of bronchospasm in patients with asthma or COPD.
Monoamine oxidase inhibitors (MAOIs)MAOIs may intensify the cardiovascular side effects of Seretide.
Tricyclic antidepressants (TCAs)TCAs may increase the risk of specific cardiovascular side effects, including irregular heart rhythms or hypertension. Combining TCAs with LABAs like Seretide containing salmeterol may increase this risk further.
KetoconazoleCombining ketoconazole with Seretide, which contains fluticasone, could result in higher concentrations of fluticasone in the body, increasing the risk of adrenal gland problems.
Ritonavir (Norvir)Ritonavir can increase the blood concentration of fluticasone.
Other corticosteroidsThe combination of other corticosteroids and fluticasone may result in systemic effects, including Cushing’s syndrome, hyperglycemia, and osteoporosis. These effects are more likely when fluticasone is taken orally or by injection, but caution is still necessary when using inhaled fluticasone.
DiureticsRisk of hypokalemia (low potassium levels)
Xanthine derivativesThis medication, when used with Seretide, has the potential to cause side effects that are commonly associated with corticosteroids. Therefore, it is essential to monitor any possible adverse reactions closely.

Strengths and Dosages of Seretide

The patient’s characteristics determine individual dosages, the severity of the ailment, and the response to prior treatment. Asthma patients usually begin with one inhalation twice daily, and their dosage can be changed as needed. Regarding dosage and administration, patients should adhere to the advice given by their healthcare provider.

Seretide Evohaler (Metered-Dose inhaler)Seretide Diskus (Dry Powder Inhaler)
AGEStrength depending on condition severityInhalations in a dayInhalations in a day
Adult (12 years and older)Seretide 100 (25 mcg fluticasone/125 mcg salmeterol)21
Seretide 250 (25 mcg fluticasone/250 mcg salmeterol)21
Seretide 500 (25 mcg fluticasone/500 mcg salmeterol)21
Children (4 years and older)Seretide 100 (25 mcg fluticasone/125 mcg salmeterol)11

Seretide Alternatives

Doctors can prescribe other medications to treat COPD and asthma besides Seretide. Some of the alternatives to Seretide include:

  • Corticosteroid Inhalers: When treating mild to moderate asthma, inhaled corticosteroids like Avamys or Entocort can be used alone. They can be used in conjunction with a long-acting beta-adrenergic blocker for more severe instances.
  • Long-acting beta Agonists (LABAs): Although LABAs like salmeterol or formoterol are usually used with corticosteroids for improved asthma control, they can be administered independently for bronchodilation.
  • Other treatments include ProAir, Trelegy Ellipta, Budesonide, Albuterol, and Symbicort.

FAQs of Seretide

Why should I rinse my mouth after taking Seretide?

Rinsing your mouth after using Seretide helps prevent side effects such as throat irritation and infections like oral thrush.

Can you cure asthma permanently and naturally?

To date, there is no cure for asthma, but it can be effectively controlled using the medication prescribed by a pharmacist.

What are the possible side effects of Seretide?

Common side effects of Seretide may include throat irritation, hoarseness, cough, headache, and oral thrush (yeast infection in the mouth). Less common but severe side effects may include increased heart rate, chest pain, and allergic reactions.

Can Seretide be used for acute asthma attacks?

No, Seretide is not used to treat acute asthma attacks. It is a maintenance medication intended for long-term control of asthma symptoms.

How should Seretide be stored?

Seretide inhalers should be stored at room temperature, away from moisture and heat.

Is it safe to stop Seretide suddenly?

Sudden stopping of the use of Seretide can cause withdrawal symptoms and could even worsen the condition.

How long does it take for Seretide to start working?

The onset of noticeable changes and improvement is after a few days to a few weeks of treatment.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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