Seretide (Fluticasone/Salmeterol)

Seretide (salmeterol/fluticasone) is a combination therapy used for asthma and COPD treatment. It comes in the form of an inhaler (Seretide evohaler or Seretide accuhaler). This inhaled corticosteroid is a long-acting beta-agonist (LABA) that helps with breathing and keeping the lungs open.

• Suitable for Adults and Children
• Equivalent of “Advair” in the U.S.
• Effects Last 12+ Hours
• Improves Breathing Abilities
• Reduces Asthma-Related Mortality and Hospital Admissions
• Improves Quality of Life
• Easy to Administer
• Effective Symptom Control

Doses of this medication are formulated as an inhaler.

1. Shake the inhaler well to mix the medicine before use
2. Remove the mouthpiece cover by pressing the sides of the cap
3. Hold the inhaler upright and place thumb under the inhaler’s base
4. Exhale fully to empty your lungs
5. Place the mouthpiece in your mouth and close your lips around it (do not bite)
6. Press the top of the inhaler to release the medicine while breathing in deeply
7. Hold your breath for a few seconds and then exhale normally
8. (Optional) Repeat steps 1-7 if another puff is needed (wait about 30 seconds between puffs)
9. Rinse your mouth with water and spit to reduce the risk of thrush
10. Replace the mouthpiece cover and store the inhaler upright in its original position

The usual dose is one puff of the 25/50 formulation twice daily – with a maximum of 100 mcg of fluticasone propionate per dose – for children aged 4 years and older. Children 12 years and older may be prescribed one puff of 25/50, 25/125, or 25/250 twice daily. The maximum dose that can be used for this age group twice per day is 50/500. Adult patients usually take two puffs of 25/125 or 25/250 twice per day. It is important that the medication is taken regularly at the same times each day to maintain consistent control.

This medication should not be used by patients when they are experiencing an exacerbation. The same goes for those with unstable or acutely deteriorating asthma. This type of inhaler is not meant for quick relief during sudden asthma symptoms. A fast-acting inhaler (such as salbutamol inhalers) should be used instead for this.

This medication should be used with caution in patients with:

• Tuberculosis
• Thyroid disorders (thyrotoxicosis)
• Pre-existing cardiovascular disorders
• Low potassium levels
• Diabetes (may slightly raise blood sugar levels)

Studies showed there is an increased risk for COPD patients taking this medication to develop pneumonia. Paradoxical bronchospasm may also occur in some rare cases after use of this type of inhaler. This may be indicated by an immediate increase of wheezing after the dose has been given.

This medication has the inhaled corticosteroid “fluticasone propionate.” This means taking this medication in high doses for long periods of time may lead to issues such as Cushing’s syndrome or Cushingoid features in some cases. It could also potentially cause one of several other systematic effects. Patients whose symptoms improve over time with use may eventually be recommended to lower their dose or stop the medication.

Patients should contact a doctor right away if their asthma suddenly gets worse.
They should also get medical help if their quick-relief inhaler does not work as well as before or if they need to use it more often than usual. They should also let their doctor know of any pre-existing conditions or medications/supplements they are taking before starting Seretide.

Experiencing side effects is not certain for everyone. However, it is still important to understand possible ones that may occur. Some of the more common side effects experienced while taking this medication include:

• Feeling dizzy
• Oral or throat yeast infection (thrush)
• Muscle or joint discomfort
• Pneumonia (serious side effect that is more common in patients with COPD)
• Irritation or soreness in the throat
• Headache
• Bone or muscle pain
• Nausea or vomiting
• Coughing or bronchitis
• Upper respiratory tract infections
• Voice changes or difficulty speaking

Children using this medication may also be more likely to experience side effects such as ear, nose, or throat infections. Some of these symptoms may resolve on their own as patients get used to the medication. However, more serious side effects or those that do not go away should be immediately reported to a medical professional for further guidance.

Serious Side Effects

Serious adverse effects are uncommon but can happen. This includes side effects such as:

• Pneumonia (more common in patients with COPD)
• Infections
• Adrenal insufficiency (more likely to occur when oral corticosteroid drug was stopped before taking this medication)
• Difficulty breathing after taking the medication
• Serious allergic reactions
• Heart or nervous system problems
• Osteoporosis
• Eye problems
• Churg-Strauss syndrome or similar conditions
• Low potassium levels
• High blood sugar
• Slowed growth (in children)

Seek emergency attention if you experience any of the serious side effects listed.

Patients should tell their doctor about medications or supplements they are taking before starting Seretide. Some known possible interactions include ritonavir and CYP3A4 inhibitors. Patients should avoid using Seretide with ritonavir or strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, or itraconazole) unless absolutely necessary. These drugs can greatly increase steroid levels and can lead to conditions like Cushing’s syndrome or adrenal suppression.

Beta-blockers can also have an interaction. Both selective and non-selective beta-blockers can reduce the effect of Seretide and worsen breathing problems. They should only be used together if a doctor determines it to be necessary. Always advise consulting a healthcare provider for personal advice on combining medications.

These inhalers should not be stored at temperatures reaching above 30°C (86°F). Do not store this medication in the freezer or refrigerator. The canisters used to hold this medication contain pressurized liquid. Do not place this medication anywhere it can be exposed to direct sunlight. The canisters should also never be burned or pierced/punctured – even if they are empty. Medication used from cold canisters may have reduced effectiveness. MyRx Outlet ships all medications – including the Seretide Evohaler – in safe and temperature-sensitive packaging to patients’ homes in the U.S.

Why should I rinse my mouth after taking Seretide?

Rinsing your mouth with water after inhalation can help avoid oral thrush. This is a type of yeast infection that can occur in the mouth.

Can you cure asthma permanently and naturally?

There is currently no known permanent or natural cure for asthma. However, medications like Seretide can help manage symptoms and prevent flare-ups so that patients can live a more comfortable and healthy life.

Are there any side effects associated with Seretide?

Common side effects may include sore throat/coughing or mild oral yeast infections. Some people may also experience nausea and headaches or dizziness. Serious effects such as pneumonia or difficulty breathing are rare but require immediate medical attention. There are several other possible side effects that patients should discuss with their doctor before starting the medication.

Can Seretide be used for acute asthma attacks?

No. Seretide is not a rescue inhaler and should not be used for sudden asthma symptoms or breathing emergencies. Use a short-acting inhaler to relieve sudden symptoms.

How should Seretide be stored?

Store Seretide below 30°C (86°F) and away from direct sunlight. Do not freeze or refrigerate.

Is it safe to stop Seretide suddenly?

No. This is dangerous to do without consulting a doctor first and getting approval. Stopping the medicine abruptly can cause symptoms to flare up.

How quickly does Seretide begin to take effect?

Patients may notice better breathing within about 30 minutes of inhalation. However, full benefits usually develop after several days or weeks of regular use.

Is Seretide a steroid inhaler?

Yes. Seretide contains fluticasone propionate – an inhaled corticosteroid that helps reduce inflammation in the lungs.

Is it okay to use Seretide every day?

Yes. Seretide is designed for daily use to keep asthma or COPD symptoms under control.

Is Seretide the same as Advair?

Yes. Seretide is the brand name used in Canada and some other countries for the same medication known as Advair in the U.S.

Is it better to take Seretide at night or in the morning?

Patients should take this medication at the same time each day as the doctor prescribes. Many patients take this medication in twice-daily doses.

At MyRx Outlet, we are committed to delivering safe, high-quality medications that you can trust. We adhere to strict regulations in every country we operate in, ensuring that your order is handled by a licensed Canadian pharmacy or a trusted partner overseas. Each medication has been legally approved by Health Canada or other respected authorities. To purchase Seretide Accuhaler & Evohaler at a discounted rate, call 1-888-551-2467.