Prasugrel is the generic antiplatelet drug sold under the trade name Effient. Prasugrel is a P2Y12 inhibitor, which blocks platelets from clumping together and forming blood clots in a patient’s veins. In a healthy individual, the ability to clot blood is a normal function, preventing excessive blood loss from minor scrapes and cuts. However, when a patient has had a heart attack and had a stent placed to reopen the heart valves, it can become necessary to prevent blood from forming clots to reduce the risk of a clot forming and traveling to the heart or brain, causing a life-threatening heart attack or stroke in patients with compromised cardiovascular systems.

Prasugrel is a platelet inhibitor or antiplatelet drug. It may also be referred to as an anticoagulant. These drugs all work by disrupting the ability of blood platelets to stick to one another. By preventing platelets’ natural clumping ability, Prasugrel helps keep the blood vessels free of obstructions, reducing the risk of a repeat heart attack or a stroke.

Prasugrel  Precautions and Warnings

Patients must take precautions when using Prasugrel due to the increased risk of bleeding. When the patient takes Prasugrel, they must proactively inform all medical and dental care providers to avoid any possible interactions or complications. If you need dentistry work performed during the period, your dentist will likely require that you stop taking Prasugrel at least seven days before any procedure.  However, stopping Prasugrel may involve some risk, so you must discuss the best way to manage your care before taking any action.

Additionally, Prasugrel has been associated with a rare but dangerous allergic reaction, angioedema. In some patients. Angioedema can be life-threatening and requires immediate medical attention. Seek immediate medical attention if you experience any of the following symptoms:

  • Chest pain
  • Rash
  • Itching
  • Swelling of the face, lips, tongue, or throat
  • Difficulty swallowing or breathing

Prasugrel Side Effects

Prasugrel is a powerful antiplatelet drug and can have severe or fatal side effects, even when taken as prescribed. While some side effects are common and likely resolve with time, other, more severe side effects could indicate a life-threatening condition. If a patient displays any severe side effects listed below, contact a medical provider immediately.

Common Side Effects

  • Back pain
  • All Bleeding
  • Chest pain
  • Cough
  • Diarrhea
  • Dizziness
  • Fatigue
  • Headache
  • High blood pressure
  • High cholesterol
  • Low blood pressure
  • Nausea
  • Arm or Leg Pain
  • Rash
  • Shortness of breath

Serious Side Effects

The most dangerous risk associated with the use of Prasugrel is the risk of excessive bleeding due to the repression of the clotting factor. Take extra care to avoid injury while taking Prasugrel, and any signs of internal bleeding or excessive external bleeding require immediate medical attention. Serious side effects include:

  • Black, tarry stools
  • Bloating
  • Swelling (especially face or extremities)
  • Blurred vision
  • Change in mental status
  • Chest pain or discomfort
  • Chills
  • Cough
  • Dark or bloody urine
  • Difficult or labored breathing
  • Dizziness
  • Fainting
  • Fever
  • Headache
  • Irregular heartbeat
  • Lightheadedness, dizziness, or fainting
  • Nervousness
  • Painful or difficult urination
  • Pale color of the skin
  • Pinpoint red spots on the skin
  • Pounding in the ears
  • Rapid weight gain
  • Seizures
  • Slow or fast heartbeat
  • Sore throat
  • Mouth Ulcers
  • Swollen Lymph Nodes
  • Tightness in the chest
  • Tingling of the hands or feet
  • Bruising
  • Lethargy
  • Weakness
  • Sudden Wight Change
  • Yellow eyes or skin

Prasugrel Drug Interactions

Prasugrel may interact with other drugs, vitamins, or supplements, resulting in unexpected or harmful side effects. Let your doctor know all your drugs, including over-the-counter, vitamins, and herbal prescriptions.

As a general rule of thumb, any class of drug with the potential to increase bleeding or reduce clotting may be contraindicated while taking Prasugrel. This includes other antiplatelet drugs, anticoagulants, and NSAIDS like Ibuprofen. The one exception to this rule is low-dose Aspirin (81 mg to 162 per day), whose value outweighs the risk.

Seek physician approval before using any of the following drugs while taking Prasugrel.

  • Eliquis
  • Cangrelor
  • Caplacizumab
  • Codeine
  • Defibrotide
  • Heparin
  • Hydromorphone
  • Morphine
  • Oxycodone
  • Oxymorphone
  • Protamine

Prasugrel Strength & Dosage

Prasugrel is available as either a 5mg or 10mg oral tablet. This medication has several serious contraindications, and the dose may be increased or decreased significantly from the standard maintenance doses shown below. You must take this medication exactly as prescribed by your doctor.

Additionally, serious side effects could occur if you stop taking Prasugrel abruptly. Consult with your prescribing physician before you stop taking this medicine.

StrengthFormDosageIndications
5mgOral tabletMaintenance: 1 tab by mouth once dailyAdults 75 years old or older and weighing less than 135 pounds
10mgOral tabletMaintenance: 1 tab by mouth once dailyAdults 74 years old or less and weighing more than 135 pounds,

Prasugrel FAQ

Do you still have questions? If you are a customer of MyRx Outlet, we can provide you with a free consultation from a licensed pharmacist. Please feel free to contact us to learn more.

Can I take Prasugrel if I am pregnant or breastfeeding?

Prasugrel should only be used during pregnancy in cases where the mother’s life depends on it, and there is no viable alternative. Inform your physician if you are pregnant, breastfeeding, or planning to breastfeed,  as there is limited information on the use of Prasugrel in pregnant women. It is not known if Prasugrel passes into breast milk, which could endanger a nursing infant.

How long do I need to take Prasugrel after a heart attack or stent placement?

The duration of treatment with Prasugrel can vary based on individual health concerns and the specific reasons the medication was prescribed. Generally, Prasugrel is taken for up to a year following a heart attack or stent placement. Your healthcare provider will determine the best length of treatment for you.

What should I do if I miss a dose of Prasugrel?

If you miss a dose of Prasugrel and you are less than halfway through the period before the next dose, then go ahead and take the missed dose. If you are past the halfway point, wait and resume your regular dosing schedule on the next dose. Please check with your doctor for more precise instructions. Never take a more potent dose than prescribed.

Are there any foods or activities I should avoid while taking Prasugrel?

Because Prasugrel reduces your blood’s ability to form clots, the risk of excessive bleeding from even a seemingly mild injury is high. Patients should take more excellent care to avoid activities that could lead to injury as the bleeding may be difficult to stop. Take extra precautions if you must use sharp-bladed objects like knives, scissors, or screwdrivers, and keep pets’ claws trimmed to reduce the risk of injury. There is no specific list of dietary restrictions associated with Prasugrel. Be sure to speak with your medical care provider if you have any concerns.

What is the difference between Prasugrel and other antiplatelet medications?

Like other antiplatelet medications, Prasugrel helps disrupt the blood’s ability to form blood clots. Some studies have indicated that Prasugrel may reach peak effect faster and work more effectively than earlier antiplatelet medications like clopidogrel (Plavix). On the downside, there may also be a higher risk of uncontrolled bleeding in certain patients. Your healthcare provider will consider your risk factors and medical history when deciding which medication is best for you.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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