Inspiolto Respimat, an FDA-approved medication, helps to treat such conditions. Its active ingredients help relax your lung muscles and widen your airways (bronchi), making breathing easy.

This article looks at what Inspiolto Respimat is, how it works, its precautions and warnings, its side effects, its drug interactions, its cost, and its possible alternatives.

Inspiolto Respimat is a medication used to cure inflammatory lung diseases that cause breathing difficulties. This drug is commonly used by people suffering from a lung disease called Chronic Obstructive Pulmonary Disease (COPD). Doctors may also administer it to cure chronic bronchitis or emphysema.

The drug contains two active ingredients, which are both bronchodilators, namely:

  • Tiotropium
  • Olodateral

How Does Inspiolto Respimat Work?

Inspiolto Respimat has two mechanisms of action in treating COPD, thanks to its two active ingredients. Working together, these two active ingredients improve airflow and help people with inflamed and obstructed airways breathe easily.

  • Tiotropium– The long-acting muscarinic antagonist (LAMA) works by inhibiting the action of acetylcholine, a neurotransmitter that activates muscarinic receptors on airway smooth muscle, resulting in bronchoconstriction. This inhibition helps to relax muscles and widen the airways.
  • Olodaterol- The long-acting beta-2-adrenergic agonist (LABA) stimulates beta two receptors, which helps to widen airways and improve airflow.

Inspiolto Respimat Precautions and Warnings 

Inspiolto Respimat is considered a safe and effective medication. However, be sure to check for its precautions and warnings and notify your doctor of any medical conditions, allergies, or medications, as they may affect how you will use this medication.

  • Allergic Reactions: Avoid using the medication if you are allergic to any of its ingredients.
  • Risk of Dizziness: Inspiolto Respimat may cause dizziness and blurred vision; therefore, avoid operating heavy machinery after taking this medication.
  • Asthma: Do not use Inspiolto Respimat for asthma. Research indicates there are increased chances of asthma-related death caused by using long-acting beta-2 agonists (LABA) to treat Asthma.
  • Pregnancy and Breastfeeding: Before administering the medication, inform your doctor if you are pregnant or breastfeeding because it is unknown whether this medication can cause harm to the fetus or pass into the breast milk causing damage to your baby.
  • Narrow-Angle Glaucoma: Be cautious when using Inspiolto Respimat if you have Narrow-Angle Glaucoma since the drug can worsen this condition and its symptoms.
  • Bladder or Urinary Problems, Enlarged prostate Seizures, and Thyroid disease: Notify your doctor if you have any of these conditions, as the drug could worsen them or their symptoms.
  • Liver Function: Your doctor may need to monitor if you have liver disease or reduced liver function to prevent Inspiolto Respimat buildup in the body.
  • Kidney Function: Kidney disease or reduced kidney function may lead to the build-up of Inspiolto Respimat in the body.

Inspiolto Respimat Side Effects

Patients should be aware of possible side effects when using Inspiolto Respimat. The side effects may be mild in some patients or life-threatening in others, depending on how the body reacts to this drug.

Common Side Effects

  • Dry skin
  • Feeling tired
  • Heartburn
  • Nosebleeds
  • Back pain
  • Dehydration
  • Cough

Severe Side Effects

  • Fungal infections inside the mouth
  • Lack of bowel movements
  • Swelling of the feet, ankles, or legs
  • Symptoms of increased pressure in the eye include blurred vision, eye pain, red eye, and swelling of the eye.
  • Signs of metabolic allergic reactions, e.g., abdominal cramps, headache, and heart palpitations.

Drug Interactions With Inspiolto Respimat

Make sure to inform your pharmacist about other medications that you are currently taking, including over-the-counter drugs, herbal medicines, or any other drugs, as they may impact the effectiveness of the medication.

Drug Interaction
AntidepressantsCombining antidepressant drugs like tricyclic with Inspiolto Respimat raises the risk of cardiovascular diseases like heart attack.
Beta-blockers (propranolol)The concurrent use of beta-blocker medication in treating high blood pressure with Inspiolto Respimat may increase bronchospasm.
Monoamine Oxidase Inhibitors (MAOIs)Monoamine Oxidase Inhibitors may interact with Inspiolto Respimat, possibly leading to increased cardiovascular side effects.
Anticholinergic MedicationsThe interaction between Inspiolto Respimat and Anticholinergic medicines may lead to increased side effects such as constipation, blurred vision, and dry mouth.
TheophyllineInteraction between these two medications increases the risk of side effects such as nausea, tremors, and palpitations.
SteroidsTakingg Inspiolto Respimat with steroids, like corticosteroids, increases the risk of having glaucoma and low potassium levels that can lead to heart palpitations.

Inspiolto Respimat Strengths, Dosages and Usage

Inspiolto Respimat is administered orally. The prescription will depend on several factors, including age, the disease you are suffering from, and how severe the condition is.

Inspiolto Respimat comes in a Respimat cartridge containing an aqueous solution comprising 2.5 µg of tiotropium and 2.5 µg of olodaterol. The medication is then administered using a Respimat inhaler device.

The ideal dosage for adults is to inhale two puffs from the device once daily, giving you a daily dose of 5 µg of tiotropium and five µg of olodaterol.

Age Drug Dosage No. of times a day
AdultTiotropium bromide2.5mg (2 puffs)Once per day
AdultOlodateral2.5mg (2 puffs)Once per day

The medication should not be used by children below the age of 18 years unless prescribed by a doctor. For best results in adults, take your medication once daily, simultaneously, every day.

Follow these steps to use the Respimat inhaler device correctly.

  • Insert the cartridge into the inhaler device
  • After the insertion, prime the device by turning the transparent part toward the arrows until it clicks.
  • Open the cap, point the inhaler towards the ground, and press the dose release button.
  • Repeat the steps until a visible cloud of medication is released.

Inspiolto Respimat Alternatives

While Inspiolto Respimat is a commonly prescribed medication for COPD management, you may need to consider alternative treatment options if you experience severe side effects or if you find the medication to be expensive.

Below are the alternatives available and how they compare to Inspiolto Respimat.

Trelegy Ellipta

Trelegy Ellipta is a triple therapy inhaler containing umeclidinium, vilanterol, and fluticasone. It offers combined bronchodilation and anti-inflammatory effects.

When acting as an anti-inflammatory agent, Fluticasone Furoate reduces inflammation in the airways, preventing exacerbations. At the same time, Umeclidinium Bromide and Vilanterol Trifenatate provide bronchodilation properties that relax airway muscles and improve airflow.

Bevespi Aerosphere

Bevespi Aerosphere has shown improvement in airway movement for moderate to severe COPD patients compared to placebo. It combines a long-acting beta-agonist (LABA), formoterol fumarate, and an anticholinergic, glycopyrrolate, to open airways and improve airflow.

Advair Diskus

Advair Diskus is a combination of fluticasone (a corticosteroid) and salmeterol (a LABA). It provides long-term symptom control for moderate to severe COPD. Fluticasone reduces inflammation in the airways and prevents exacerbations, while salmeterol stimulates beta-2 receptors and widens the airways.

Anoro Ellipta

Anoro Ellipta is effective for COPD treatment. It combines umeclidinium, a long-acting muscarinic antagonist (LAMA) that relaxes airway muscles and prevents airway muscles from tightening, and vilanterol, a long-acting beta-2-adrenergic agonist (LABA) that dilates airways.


Symbicort is another inhaler used for both COPD and asthma management. It contains:

  • Budesonide– An inhaled corticosteroid (ICS) that reduces airway inflammation, preventing exacerbations and
  • Formoterol– A long-acting beta2-adrenergic agonist (LABA) that dilates airways.

FAQs of Inspiolto Respimat

Does Inspiolto Respimat contain a steroid?

Inspiolto Respimat doesn’t contain any steroids. This medication is made of two components: olodaterol, a long-acting beta2-agonist (LABA), and tiotropium, a long-acting anticholinergic (LAMA).

How does Inspiolto Respimat work?

The medication has two mechanisms of action. It contains tiotropium, which inhibits the action of acetylcholine, a neurotransmitter that plays a role in bronchoconstriction. By inhibiting acetylcholine action in the body, tiotropium helps relax and widens the airways, making breathing easier for individuals with COPD. The drug also contains Olodaterol, which stimulates beta2 receptors that widen the airways and improve airflow.

How long does it take for Inspiolto Respimat to work?

It typically takes about 15 minutes for Inspiolto Respimat to start working after inhalation.

How is the Inspiolto Respimat drug stored?

Inspiolto Respimat should be stored at room temperature, away from excess heat and direct sunlight, and in a secure location far from children’s reach.

What are the common side effects of Inspiolto Respimat?

Inspiolto Respimat is generally well-tolerated, but it has some side effects such as dryness of the mouth, dizziness, especially when getting up from a lying or sitting position, increased blood pressure, urinary retention, and respiratory infections.

How long should I use Inspiolto Respimat before disposing of it?

You can safely discard your inhaler after three months, even if it is loaded.

Can I drink water after using the Inspiolto Respimat inhaler?

After inhaling, you can rinse your mouth with water but do not swallow the water. Instead, you should gargle and spit it.

What is the cost of Inspiolto Respimat in America?

The Inspiolto Respimat inhalation aerosol (2.5 mcg-2.5 mcg/inh) costs approximately $519 for a supply of 4 grams of the medication.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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