Daliresp is a medication that treats ongoing chronic obstructive pulmonary disease. It is used to decrease the risk of exacerbations of COPD symptoms in adults with severe COPD.

Since this medication is not a bronchodilator, patients should not use it to treat sudden breathing problems. Instead, it works best for long-term management of COPD.

How Does Daliresp Work?

Daliresp, a selective phosphodiesterase 4 (PDE4) inhibitor, works by inhibiting the activity of PDE4, an enzyme that modulates inflammation. The inhibition reduces the number of inflammation mediators released and prevents tissue damage, resulting in a healthy lung that allows easy breathing.

Precautions and Warnings With Daliresp

Daliresp has several precautions and warnings you need to follow to minimize cases of side effects that may occur due to the medication.

  • Weight Loss: It is advisable to closely monitor your weight when using Daliresp as it can cause severe weight loss. This weight loss reverses once you discontinue the medication.
  • Pregnancy and Breastfeeding: Daliresp can pass into breast milk, so lactating mothers should consult a medical doctor before using the medication. Similarly, Daliresp might affect the growth of the fetus, so pregnant women should seek medical advice before using the drug.
  • Driving or Using Heavy Machinery: Do not operate on heavy machinery when under this medication because it causes dizziness and drowsiness.
  • Acute Bronchospasm: This drug is not designed to open airways like typical bronchodilators; therefore, do not rely on the medication for immediate relief during sudden asthma attacks or acute bronchospasm.
  • Psychiatric Events: Using Daliresp may cause certain types of mental illness, such as depression, suicidal thoughts, anxiety, and insomnia. Discontinue the medication immediately and seek medical advice if you experience any signs and symptoms of mental illness.
  • Medical History: Inform your doctor about your medical history, such as liver disease, kidney disease, cancer, and heart disease. Daliresp could worsen the symptoms of some of these conditions.
  • Ongoing Discomfort: You may experience discomfort such as stomach pain, headaches, and nausea on your first time using Daliresp. If the symptoms persist, seek medical advice immediately.

Dalirespt Side Effects

Despite its effectiveness and safety, Daliresp may have some side effects that can either be severe or temporary. If side effects persist or become severe, seek medical attention immediately.

Common Side Effects

  • Diarrhea
  • Headache
  • Dizziness
  • Back pain
  • Flu-like symptoms
  • Decreased appetite

Severe Side Effects

  • Depression
  • Allergic reactions
  • Weight loss
  • Fast or irregular heartbeats
  • Shaking
  • Allergies symptoms, e.g., difficulty breathing, hives, and swelling of your face and throat

Drug Interactions With Daliresp

Taking Daliresp with other medication may alter how it works, or it may raise the likelihood of severe side effects. Talking with your doctor about your medications is essential to avoid potential interactions.

Drug Interaction
PhenytoinThe interaction between phenytoin (found in Dilantin) and Daliresp may lead to a decrease in metabolism, possibly reducing the effectiveness of Daliresp in treating COPD symptoms.
FluconazoleUsing fluconazole (Diflucan) and Daliresp concomitantly may increase the blood sugar level, which may increase the risk of side effects such as nausea, diarrhea, and insomnia.
CiprofloxacinCiprofloxacin increases the concentration of Daliresp in the body, which can lead to adverse reactions such as gastrointestinal symptoms and severe headaches.
KetoconazoleUsing ketoconazole with Daliresp concurrently may increase the risk of side effects such as gastrointestinal disturbances, headache, and weight loss.
RifampinConcurrent use of Daliresp and Rifampin (Rifadin) may lower Daliresp concentrations, reducing its effectiveness in managing COPD symptoms and worsening the disease.
ErythromycinUsing erythromycin while using Daliresp can result in a greater likelihood of experiencing side effects such as headaches, diarrhea, and decreased appetite.

Daliresp Strengths and Dosages

Daliresp comes in tablet form with two starting doses of 250 and 500 mcg. Depending on your condition, your doctor will prescribe different strengths and dosages of Daliresp.

For the most part, however, physicians prescribe 250 mcg for the first four weeks as the starting dose. This dose is not necessarily effective and should be increased to a maintenance dose of 500 mcg daily.

No dose is indicated for children below the age of 18. A medical professional should determine the utilization and dosage of this medication in children.

Cost of Daliresp in America

The price of Daliresp in America is $320.99 for a supply of 20 tablets, 250mcg. On the other hand, a supply of 30 tablets 500mcg will set you back around $476.84.

These prices are for patients who pay out of pocket and are not valid for insurance. If you want to cut costs, you can opt for the generic version of Daliresp.

Daliresp Alternatives

Apart from Daliresp, other alternative medications can be used in the prevention of COPD and asthma. They include:

  • Symbicort: This combination of budesonide and formoterol is used to treat conditions like asthma and COPD. Unlike Daliresp, Symbicort is also administered to treat and prevent acute bronchospasm.
  • Trelegy Ellipta┬ácombines three active ingredients: fluticasone, umeclidinium, and vilanterol. Trelegy is used in treating and preventing COPD and asthmatic conditions.
  • Other medications: Other medications used in treating COPD and asthma are prednisone, montelukast, Anoro, Incruse, Stiolto Respimat, and Tudorza Pressair.

FAQs With Daliresp

What does Daliresp do for the lungs?

The medication helps enhance lung health and reduce exacerbations of COPD symptoms in patients with severe COPD linked with bronchitis.

Can a child take Daliresp?

Please don’t administer the medication to children under 18 years unless a doctor says it.

What are the psychiatric side effects of Daliresp?

In some cases, the medication may lead to suicidal thoughts, depression, and insomnia. If you notice these effects, inform your doctor immediately.

Is Daliresp an anti-inflammatory?

Yes. The medicine helps ease lung inflammation associated with COPD, aiming to control COPD symptoms in individuals with severe COPD.

What are the common side effects of Daliresp?

Common side effects of Daliresp include headaches, stomach pain, nausea, diarrhea, back pain, dizziness, and decreased appetite.

Is Daliresp a steroid?

No. Daliresp is not a steroid. It belongs to a group of drugs called phosphodiesterase inhibitors that reduce inflammation inside the lungs.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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