Incruse Ellipta is an FDA-approved prescription medicine primarily used in the treatment of COPD. It belongs to a class of medications known as long-acting muscarinic antagonists (LAMA) or anticholinergics. The active ingredient in Incruse Ellipta is Umeclidinium, which helps relax the airways, making it easier for individuals to breathe.

Incruse Ellipta works by targeting and blocking specific receptors called muscarinic receptors in the airways. These receptors are responsible for controlling the contraction of smooth muscles surrounding the air passages. By inhibiting these receptors, Incruse Ellipta helps to dilate the airways, leading to improved airflow and reduced respiratory symptoms.

Incruse Ellipta is intended for adult patients diagnosed with COPD, a chronic respiratory condition that causes difficulty in breathing. COPD encompasses chronic bronchitis and emphysema, and it affects millions of people worldwide. Physicians often prescribe Incruse Ellipta as part of a comprehensive treatment plan to manage COPD symptoms effectively.

While Incruse Ellipta is beneficial for many COPD patients, it may not be suitable for everyone. Individuals with a history of hypersensitivity to Umeclidinium or any other components in the medication should avoid using it. Additionally, individuals with asthma or acute bronchospasm should refrain from using Incruse Ellipta.

Chronic Obstructive Pulmonary Disease (COPD)

COPD, or Chronic Obstructive Pulmonary Disease, is a chronic lung condition that hinders airflow and makes breathing difficult. It is a term encompassing two primary conditions: chronic bronchitis and emphysema. In COPD, the airways and air sacs in the lungs become damaged and lose their elasticity, leading to obstruction and trapping of air. As the disease progresses, patients may experience shortness of breath, coughing, wheezing, and other respiratory symptoms.

COPD is a widespread health issue globally. According to the World Health Organization (WHO), it is the third leading cause of death worldwide. It affects people of all ages, but it is more common among individuals over the age of 40, especially those with a history of smoking or exposure to harmful pollutants.

The primary cause of COPD is long-term exposure to irritants that damage the lungs and airways. Cigarette smoking is the most significant risk factor for COPD, responsible for around 80-90% of COPD-related deaths. Other factors such as exposure to secondhand smoke, air pollution, occupational dust and chemicals, and genetic factors can also contribute to the development of COPD.

Warnings and Precautions

While it is highly effective in improving breathing and reducing symptoms, it’s essential to use it with caution and awareness of potential risks.

  1. Not a Rescue Medication: Incruse Ellipta is not intended for the relief of acute breathing problems or bronchospasms. It should not be used as a rescue medication during sudden COPD exacerbations.
  2. Allergic Reactions: Some individuals may be hypersensitive to umeclidinium or the other ingredients in Incruse Ellipta. If you experience signs of an allergic reaction such as rash, itching, swelling, severe dizziness, or difficulty breathing, seek immediate medical attention.
  3. Medical History Considerations: Inform your healthcare provider about your complete medical history, especially if you have a history of narrow-angle glaucoma, urinary retention, or prostatic hyperplasia, as Incruse Ellipta may worsen these conditions.
  4. Pregnancy and Breastfeeding: Consult your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding before using Incruse Ellipta. The risks and benefits for you and your baby should be assessed.
  5. Pediatric Use: Incruse Ellipta is not recommended for children and adolescents under the age of 18 years. Safety and efficacy in this age group have not been established.
  6. Proper Inhaler Technique: Learn the correct inhalation technique from your healthcare provider to ensure the medication reaches your lungs effectively.
  7. Avoiding Contamination: Keep the inhaler device clean and dry at all times. Avoid contact with water or other liquids to prevent contamination.
  8. Regular Check-ups: Attend regular check-ups with your doctor to monitor your progress and address any concerns related to Incruse Ellipta usage.
  9. Smoking Cessation: If you are a smoker, quitting smoking is crucial for better COPD management. Smoking can worsen the condition and reduce the effectiveness of Incruse Ellipta.
  10. Avoiding Triggers: Identify and avoid triggers that worsen your COPD symptoms, such as smoke, dust, and pollutants.

Side Effects

While Incruse Ellipta is effective, it is important to understand the side effects of the medication.

Common Side Effects of Incruse Ellipta

  • Dry Mouth: One of the most frequently reported side effects is dry mouth. This can be alleviated by staying hydrated and using sugarless candies or gum.
  • Throat Irritation: Some individuals may experience mild irritation in their throat after using the inhaler. Gargling with warm saltwater may provide relief.
  • Headache: Headaches may occur initially as your body adjusts to the medication. If the headaches persist or become severe, consult your healthcare provider.
  • Nasal Congestion: Incruse Ellipta may cause nasal congestion in some users. Over-the-counter saline nasal sprays may help alleviate this symptom.
  • Coughing: While Incruse Ellipta helps improve breathing, it may also lead to an increase in coughing in some individuals. This is generally temporary and should subside with continued use.

Rare Side Effects of Incruse Ellipta

  • Blurred Vision: Incruse Ellipta could potentially cause temporary blurred vision. If this occurs, avoid activities that require clear vision until it resolves.
  • Palpitations: Some individuals may notice an irregular or rapid heartbeat. If you experience persistent or concerning palpitations, seek medical attention.
  • Allergic Reactions: In rare cases, individuals may develop an allergic reaction to Incruse Ellipta. Symptoms may include rash, itching, swelling, severe dizziness, and difficulty breathing. Seek immediate medical attention if you experience any of these signs.
  • Muscle Cramps: Incruse Ellipta may cause muscle cramps or muscle pain in some users. Gentle stretching exercises and staying hydrated may help prevent this side effect.
  • Tremors: In rare instances, users may experience hand tremors or shaky hands. If this becomes bothersome, consult your healthcare provider.

Severe Side Effects of Incruse Ellipta

  • Severe Breathing Difficulties: Some individuals may experience a sudden worsening of breathing difficulties. If this happens, go to the nearest emergency room or call for medical help immediately.
  • Chest Pain: Incruse Ellipta may rarely cause chest pain. If you experience any chest discomfort, do not ignore it, and seek medical evaluation promptly.
  • Vision Changes: Severe vision changes, such as sudden loss of vision, may occur. This is a medical emergency, and you should seek immediate attention from an eye care professional.
  • High Blood Pressure: Incruse Ellipta may lead to elevated blood pressure in some users. Regular monitoring of blood pressure is essential during treatment.
  • Urinary Difficulties: In rare cases, individuals may experience difficulty in passing urine or changes in the frequency of urination. Consult your doctor if you notice such symptoms.


While it offers significant benefits in improving lung function and easing breathing, it is crucial to be aware of potential interactions with other drugs, herbs, and foods.

Drug Interactions with Incruse Ellipta

  1. Beta-Adrenergic Agonists: Combining Incruse Ellipta with short-acting or long-acting beta-agonists may enhance bronchodilation and improve COPD symptoms. However, it is essential to use them as prescribed and under medical supervision to avoid adverse effects.
  2. Other Anticholinergic Medications: Concurrent use of multiple anticholinergic drugs may lead to an increased risk of anticholinergic side effects such as dry mouth, blurred vision, and constipation. Always inform your healthcare provider about all medications you are taking.
  3. Xanthine Derivatives: Theophylline and other xanthine derivatives may interact with Incruse Ellipta, potentially increasing the risk of side effects. Regular monitoring and dosage adjustments may be necessary.
  4. CYP3A4 Inhibitors: Medications that inhibit the CYP3A4 enzyme may increase Incruse Ellipta’s concentration in the body, leading to potential side effects. Consult your doctor if you are taking any CYP3A4 inhibitors.
  5. CYP3A4 Inducers: On the other hand, CYP3A4 inducers may decrease Incruse Ellipta’s effectiveness. Dose adjustments or alternative medications might be considered if needed.
  6. Diuretics: Some diuretics can cause potassium depletion, which may increase the risk of cardiac arrhythmias when used with Incruse Ellipta. Regular monitoring of potassium levels is crucial.

Herbal Interactions with Incruse Ellipta

  1. Licorice Root: Licorice root may lead to potassium depletion, similar to certain diuretics. Combined use with Incruse Ellipta might increase the risk of cardiac adverse effects. Avoid excessive consumption of licorice root.
  2. Ephedra: Ephedra contains ephedrine, which may cause cardiovascular side effects. Using it concurrently with Incruse Ellipta could elevate the risk of adverse reactions.
  3. St. John’s Wort: St. John’s Wort is known to induce CYP3A4, potentially reducing the effectiveness of Incruse Ellipta. Patients using this herb should be closely monitored.
  4. Ginseng: Ginseng may have stimulant properties that could interact with the effects of Incruse Ellipta. Exercise caution when combining the two.

Food Interactions with Incruse Ellipta

  1. Grapefruit: Grapefruit and grapefruit juice contain compounds that inhibit CYP3A4, which might increase Incruse Ellipta’s concentration in the body. It is advisable to avoid grapefruit while on this medication.
  2. High-Potassium Foods: As Incruse Ellipta can lead to potassium retention, it is essential to moderate the intake of high-potassium foods like bananas, oranges, and potatoes to prevent hyperkalemia.
  3. Caffeinated Beverages: Caffeine may have mild bronchodilatory effects. While moderate consumption of caffeinated beverages is generally safe, excessive intake may lead to jitteriness or increased heart rate when combined with Incruse Ellipta.
  4. Alcohol: Incruse Ellipta does not have specific interactions with alcohol. However, excessive alcohol consumption can worsen COPD symptoms and should be avoided.

How to Use

Using Incruse Ellipta correctly is essential to effectively manage COPD symptoms and improve your overall lung function.

  1. Check the Expiry Date and Integrity: Before using Incruse Ellipta, examine the inhaler for the expiry date. Ensure that the foil blister is intact and undamaged. If the blister is torn or open, do not use it, and instead, get a new one.
  2. Prepare the Incruse Ellipta Inhaler: Hold the inhaler with the mouthpiece facing up and open the cover fully until you hear a click sound. This action loads the dose, and you will see the dose counter changing.
  3. Breathe Out Completely: Before inhaling the medication, breathe out fully, away from the inhaler.
  4. Inhale the Medication: Place the mouthpiece between your lips, forming a tight seal, and breathe in quickly and deeply through your mouth. This action will release the medication into your lungs. Do not exhale into the inhaler.
  5. Hold Your Breath: Hold your breath for about 10 seconds to allow the medication to distribute in your airways effectively.
  6. Close the Inhaler: Close the inhaler cover firmly to protect it from dust and debris.
  7. Rinse Your Mouth: To minimize the risk of side effects, rinse your mouth thoroughly with water after using Incruse Ellipta.


Proper dosing of Incruse Ellipta is crucial for achieving optimal results and effectively managing COPD.

Initial Dosing of Incruse Ellipta

When starting Incruse Ellipta, the typical initial dose is one inhalation (55 mcg of umeclidinium) once daily. It is crucial to follow the healthcare provider’s instructions carefully when using the inhaler for the first time. Patients should be educated on the proper inhalation technique to ensure that they receive the correct dose.

Maintenance Dosing of Incruse Ellipta

After the initial dose, patients should continue with the maintenance dose of one inhalation (55 mcg) once daily. It is essential to use the inhaler at the same time each day to maintain consistent therapeutic levels of the medication in the body. Compliance with the prescribed maintenance dose is vital for the long-term management of COPD.

Missed Dose of Incruse Ellipta

If a patient forgets to take their regular dose of Incruse Ellipta, they should take it as soon as they remember. However, if it is almost time for the next scheduled dose, they should skip the missed one and continue with their usual dosing schedule. Double dosing to make up for a missed dose should be avoided. In case of any doubts or concerns, patients should consult their healthcare provider.

Overdose of Incruse Ellipta

An overdose of Incruse Ellipta is unlikely, given the nature of the medication. However, if a significantly higher than recommended dose is ingested accidentally, medical attention should be sought immediately. Common symptoms of an overdose may include severe dry mouth, difficulty urinating, blurred vision, and an unusually fast heartbeat.


To ensure Incruse Ellipta remains effective, it is essential to store it under the appropriate conditions.

  1. Keep Away from Moisture: Moisture can degrade the powder inside the inhaler. Store it in a dry place, and avoid exposing it to humid environments like bathrooms.
  2. Protect from Light: Direct exposure to sunlight or artificial light may impact the medication’s stability. Store the inhaler in its original packaging to shield it from light.
  3. Avoid Extreme Temperatures: Extreme heat or cold can affect the efficacy of the medication. Keep the Incruse Ellipta at room temperature, between 68°F to 77°F (20°C to 25°C).


IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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