Entresto (Sacubitril/Valsartan)
Entresto is a prescription heart failure medication that combines a neprilysin inhibitor (sacubitril) and an ARB (valsartan). It is used to reduce the risk of cardiovascular death and heart failure hospitalization in certain patients with chronic heart failure, and it is taken by mouth on a scheduled dosing plan set by a prescriber.
We only dispense medications with a valid prescription from a licensed prescriber.
All prescriptions are reviewed and verified before dispensing. Orders may be delayed or declined if prescription details are missing, do not match the patient information on file, appear altered, or are expired. We may also refuse service if we believe an order is intended for resale or redistribution.
What You Receive
- Entresto (or generic) in sealed manufacturer packaging
- Personalized prescription instructions based on your prescriber’s directions
- Medication information leaflet provided by the manufacturer
- Itemized invoice detailing your order
- Rx Required
From $260.95 – $350.25
Shipping & Delivery
- Shipped from licensed pharmacy partners
- Tracking information is provided once your order ships
Delivery times may vary based on location and prescription verification.
This page is for general information only and is not medical advice. For medical questions, please speak with your prescriber. See Sources & Methodology for how this information is reviewed and referenced.
Entresto Key Facts
What Entresto is
Entresto is an ARNI combination medication made of sacubitril and valsartan. It is available as film-coated tablets, and some patients may be prescribed an oral pellet form depending on age and swallowing needs.
What it’s used for
Entresto is used in chronic heart failure to reduce the risk of cardiovascular death and hospitalization for heart failure. Treatment decisions are based on the patient’s type of heart failure and overall clinical picture.
How it works
Entresto works through two pathways at the same time. Sacubitril increases beneficial heart-protective peptides by inhibiting neprilysin, and valsartan blocks angiotensin II signaling to help reduce strain on the heart and blood vessels.
Entresto Safety Overview
Entresto has strict “do not combine” rules with certain blood pressure medicines.
Entresto Warnings & Precautions
Entresto can cause serious concerns that need monitoring, especially related to pregnancy risk, swelling reactions, low blood pressure, kidney function, and potassium.
Do not use Entresto if:
- Hypersensitivity to any component
- History of angioedema related to previous ACE inhibitor or ARB therapy
- Concomitant use with ACE inhibitors
- Concomitant use with aliskiren in patients with diabetes
Key warnings to know
- Pregnancy risk with fetal harm, stop as soon as pregnancy is detected
- Angioedema risk with swelling of face, lips, tongue, or throat
- Low blood pressure risk especially if dehydrated or on strong diuretics
- Kidney function can worsen in susceptible patients
- High potassium risk especially in kidney disease or with potassium-raising medicines
Side Effects and When to Get Help
Most side effects relate to blood pressure, potassium, kidney function, or cough. Seek help right away for swelling reactions or severe symptoms, and contact your prescriber if side effects are persistent or worsening.
Possible side effects may include
- Low blood pressure symptoms such as dizziness or lightheadedness
- High potassium on bloodwork
- Cough
- Kidney function worsening or kidney-related lab changes
- Dizziness
Get urgent help right away for
- Swelling of face, lips, tongue, or throat
- Trouble breathing or severe allergic symptoms
- Fainting or severe dizziness that does not improve
- Very little urine or sudden worsening swelling
Interactions
Entresto has important interaction rules with other blood pressure medicines and several common drug groups. A medication review matters before starting, stopping, or switching therapies.
Interactions you should discuss with your prescriber include
- ACE inhibitors with a required 36-hour washout before or after use
- Other ARBs since Entresto already contains valsartan
- Aliskiren especially in diabetes or reduced kidney function
- Potassium supplements, salt substitutes, or potassium-sparing diuretics
- NSAIDs including COX-2 inhibitors
- Lithium
Entresto Drug Facts
| Category | Details |
|---|---|
| Brand Name | Entresto |
| Drug Class | ARNI (neprilysin inhibitor + ARB) |
| Indication | Chronic heart failure, reduces cv death and hf hospitalization |
| Dosage Forms | Oral tablets; oral pellets (select patients) |
| Strengths | Tablets 24/26, 49/51, 97/103 mg; pellets 6/6, 15/16 mg |
| Administration Timing | Twice daily (titrated to target as tolerated) |
| Boxed Warning | Fetal toxicity; ACE inhibitor use; prior ACEi/ARB angioedema; aliskiren in diabetes; hypersensitivity |
| Storage | 20°C to 25°C; excursions 15°C to 30°C; protect from moisture |
| Missed Dose | Take when remembered unless close to next dose; do not double |
| Alternatives | Enalapril (Vasotec), lisinopril (Zestril), valsartan (Diovan), losartan (Cozaar) |
Helpful Information
How To Buy Entresto Online
1
Select Your Prescribed Entresto Dosage & Strength
Choose the strength and quantity that matches your prescription, then add it to your cart. Orders are limited to a 90-day supply per fill.
2
Complete Checkout
Ensure your shipping and contact information is correct so your order can be processed without delays.
3
Submit Your Entresto Prescription
Upload your prescription at checkout. If you need a transfer, provide your prescriber or current pharmacy details and we will request it on your behalf.
Prescription & Dispensing Standards
- Prescription required for all orders and reviewed for pharmacy and regulatory compliance
- Dispensed by licensed pharmacy partners
- Orders are held if information is missing, unclear, or does not match.
- No substitutions without prescriber approval, and no controlled substances.
Our Guarantee
At MyRx Outlet, we are committed to delivering safe, high-quality medications that you can trust. We adhere to strict regulations in every country we operate in, ensuring that your order is handled by a licensed Canadian pharmacy or a trusted partner overseas. Each medication has been legally approved by Health Canada or other respected authorities. To purchase Entresto (or generic) at a discounted rate, call 1-888-551-2467.
FAQs
What is Entresto used for?
Entresto is used in chronic heart failure to reduce the risk of cardiovascular death and hospitalization for heart failure.
How do I take Entresto?
Entresto is typically taken twice daily. Your prescriber chooses the starting dose and adjusts it based on blood pressure, kidney function, and tolerance.
Can I take Entresto with an ACE inhibitor?
No. Entresto must not be taken with an ACE inhibitor, and a 36-hour washout is required when switching.
What should I do if I miss a dose?
Take it when you remember unless it is close to your next dose. Do not take two doses at the same time.
What side effect should I watch for most closely?
Swelling reactions (angioedema) and severe low blood pressure symptoms are the most urgent concerns. Seek help right away if you have facial or throat swelling or fainting.
Ordering & Prescription FAQs
Do I need a prescription?
Yes, a prescription is required. Refills depend on what your prescriber authorizes.
How do I submit my prescription?
You can upload it through our Upload Prescription page, email it to info@myrxoutlet.com, or fax it to 1-888-230-1245. If you need a prescription transfer, just let us know at checkout and include your pharmacy or prescriber contact details.
When is my payment processed?
Your payment is processed only after your prescription and order have been reviewed and approved by our licensed pharmacy team. Once everything is confirmed, we’ll process payment and prepare your order for shipping.
What happens if my prescription can’t be verified?
Your order may be placed on hold or declined if prescription details are missing, don’t match, are expired, or can’t be confirmed.
Sources
FDA Prescribing Information / Patient Information, ENTRESTO (sacubitril and valsartan) tablets
https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/207620s025%2C218591s000lbl.pdf
DailyMed Drug Label / Medication Guide, ENTRESTO (sacubitril and valsartan) tablet, film coated
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=000dc81d-ab91-450c-8eae-8eb74e72296f