Zestril is an angiotensin-converting enzyme (ACE) inhibitor administered to manage high blood pressure in adults and children aged 6 years and older. This medication is also prescribed in adults to treat congestive heart failure and increase the chances of survival after a heart attack.

Being an angiotensin-converting enzyme (ACE) inhibitor, Zestril works by decreasing Angiotensin II in the body, a chemical substance that raises blood pressure through vasoconstriction.

When the levels of this chemical are low, blood vessels relax, reducing the workload on the heart and allowing it to pump blood more efficiently.

Zestril Precautions and Warnings

  • Pregnancy: Avoid taking Zestril when pregnant or planning to get pregnant because it can affect the fetus during the second or third trimester causing oligohydramnios and possibly death.
  • Angioedema: Taking Zestril may cause you to develop angioedema on your face, tongue, or larynx. Discontinue the medication immediately and seek medical advice if you notice angioedema symptoms like welts, or swelling below the skin.
  • Low Sodium levels: Inform your doctor if you have low sodium levels because it may increase the risk of experiencing low blood pressure as a side effect of Zestril,
  • Liver Function: Zestril can decrease liver function, potentially causing liver failure. If you experience any signs and symptoms of decreased liver function such as fatigue, nausea, or loss of appetite, stop taking the medication and inform your doctor.
  • Diabetes: Taking Zestril when having diabetes may lead to low blood sugar levels or it can worsen your diabetic condition.
  • Kidney Function: Before taking Zestril, inform your doctor if you have any kidney conditions because it may increase the risk of having kidney problems such as narrowed blood vessels in your kidney.

Side Effects of Zestril

Zestril may cause potential side effects in some patients. Understanding the possible side effects associated with the medication is essential for ensuring safe and effective management for both patients and healthcare providers.

Common Side Effects

  • Dry cough
  • Dizziness
  • Blurred vision
  • Diarrhea
  • Profuse sweating
  • Unusual weakness or tiredness
  • Fever
  • Sore throat

Severe Side Effects

  • Confusion
  • Difficulty breathing
  • Indigestion
  • Loss of appetite
  • Irregular heartbeat
  • Fainting
  • Chest pain
  • Kidney problems

Drug Interactions With Zestril

Zestril can interact with different medications and affect how it works. Understanding the potential drug interaction of zestril with other medications is important in ensuring safe and optimal medication management.

LithiumThe interaction between Zestril and lithium increases lithium levels in your blood, which may lead to lithium toxicity causing symptoms like muscle weakness, tremors, and drowsiness.
AliskirenUsing aliskiren concurrently with Zestril lowers your blood pressure and increases the risk of kidney impairment, leading to hypotension and hyperkalemia.
InsulinZetril enhances blood sugar lowering the effects of insulin and oral diabetes. This may lead to symptoms such as confusion, profuse sweating, rapid heartbeat, and fainting.
CyclosporineCombining these two medications increases blood levels of cyclosporine by reducing its metabolism in your liver. This may cause high blood pressure, kidney damage, and tremors.
AmitriptylineConcurrent use of Amitriptyline and Zestril may cause side effects such as urinary retention, confusion, dry mouth, constipation, and blurred vision.
DiureticsCombining diuretics with Zestril enhances the blood pressure-lowering effects of both medications which may lead to a serious drop in blood pressure causing side effects such as dizziness, dehydration, and electrolyte disturbances.

Strengths and Dosages of Zestril

Age Dosage  No. Times a Day
 Initial Dose Maintenance DoseMaximum Dose  


5 mg – 10 mg20 mg – 40 mg80 mgOnce per day

The strengths and dosage of Zestril are determined by various factors like age and weight of children, the condition being treated, the severity of the condition, kidney function, laboratory results including levels of potassium, sodium, and fluids, blood pressure readings, and any other concurrent medications you are taking.

Zestril is meant for oral ingestion, it can be crushed and used to prepare an oral liquid suspension which is then swallowed.

Cost of Zestril in America

The price of Zestril oral tablet 2.5 mg dosage is $1,269 for a 90-tablet supply. The cost may fluctuate depending on the pharmacy you buy the medication. These prices are applicable for customers paying out of pocket and may not be compatible with insurance coverage.

Zestril Alternatives

Exploring different medicines for hypertension broadens therapeutic options and enables health professionals to tailor treatments to patient’s needs. Some Zestril alternatives doctors can recommend based on your needs include:

Zestril FAQs

What is Zestril used for?

Zestril is primarily used in treating high blood pressure and heart failure. It is also administered to increase the chances of survival after a heart attack.

How long does Zestril take to work?

You should expect Zestril to start lowering your high blood pressure within a few hours of administration. However, it may take several weeks to achieve its maximum therapeutic effect.

How does Zestril work?

Zestril works by inhibiting the activity of angiotensin-converting enzyme, which prevents the formation of angiotensin II. By blocking angiotensin II, Zestril promotes relaxation and dilation of blood vessels hence lowering blood pressure levels.

What is the generic name for Zestril?

The generic name of Zestril is called Lisinopril.

What drug company makes Zestril?

Zestril is made by AstraZeneca a Pharmaceutical and Biotechnology Company based in the UK.

What should I avoid when taking Zestril?

Avoid taking diets that have moderately high or high potassium levels while taking Zestril medication.

What are the side effects of Zestril?

The side effects of Zestril include coughing, dizziness, headache, irregular heartbeats, feeling faint, nausea, upset stomach, and depression.

Does Zestril cause weight gain?

No. Zestril has minimal impact on weight gain but it may cause a slight weight reduction during administration.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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