Edarbi, known generically as azilsartan medoxomil, is a potent and selective angiotensin II type 1 (AT1) receptor blocker. It exerts its effects by targeting and blocking the angiotensin II receptors, which are responsible for vasoconstriction and water retention. By doing so, Edarbi relaxes and widens the blood vessels, reducing the force against the vessel walls and lowering blood pressure.

Edarbi’s mechanism of action revolves around the renin-angiotensin-aldosterone system (RAAS), a critical regulator of blood pressure and fluid balance in the body. When blood pressure drops or blood volume decreases, the kidneys release an enzyme called renin into the bloodstream. Renin then converts angiotensinogen into angiotensin I. Further, an enzyme called angiotensin-converting enzyme (ACE) converts angiotensin I into angiotensin II, a potent vasoconstrictor.

Angiotensin II binds to AT1 receptors on blood vessels and triggers vasoconstriction, leading to elevated blood pressure. Additionally, it stimulates the release of aldosterone, which promotes sodium and water retention, further contributing to hypertension.

Edarbi effectively blocks the AT1 receptors, preventing angiotensin II from binding and exerting its vasoconstrictive effects. This action helps dilate blood vessels, lower blood pressure, and reduce the workload on the heart.

Edarbi is primarily prescribed to adults with essential hypertension, which is high blood pressure without an identifiable underlying cause. It is not indicated for pediatric patients. Physicians may also consider Edarbi for patients who have difficulty controlling their blood pressure with other antihypertensive medications or who experience adverse effects with alternative treatments.

What is Essential Hypertension?

Essential hypertension is a chronic medical condition characterized by consistently elevated blood pressure levels. Unlike secondary hypertension, which is caused by an underlying health issue, essential hypertension develops gradually over time without any identifiable cause. It typically affects adults and becomes more prevalent with age.

Essential hypertension occurs when the blood vessels narrow, leading to increased resistance in the arteries, which, in turn, forces the heart to pump harder to circulate blood throughout the body. As a result, the force exerted on the walls of the arteries increases, causing the blood pressure to rise.

Effectively managing essential hypertension is crucial in preventing complications and reducing the risk of heart disease, stroke, and other health issues. Treatment plans often include a combination of lifestyle changes and medications.

Warnings and Precautions

Edarbi is a medication prescribed to treat hypertension, also known as high blood pressure. This antihypertensive drug is effective in managing blood pressure levels and reducing the risk of associated complications. However, like any medication, Edarbi comes with warnings and precautions that patients need to be aware of to use it safely and effectively.

  • Proper Dosage and Administration: Before starting Edarbi, patients should consult a healthcare professional to determine the appropriate dosage. It is crucial to follow the prescribed dosage and administration instructions carefully.
  • Hypersensitivity Reactions: Patients with a history of hypersensitivity to Azilsartan medoxomil or any other ARBs should avoid using Edarbi. Hypersensitivity reactions may include rash, itching, swelling, severe dizziness, or difficulty breathing.
  • Pregnancy and Breastfeeding: Edarbi should not be used during pregnancy as it may cause harm to the developing fetus. Pregnant women should discuss alternative treatment options with their healthcare provider. Additionally, breastfeeding mothers should avoid Edarbi, as it may pass into breast milk and harm the nursing infant.
  • Children and Adolescents: The safety and effectiveness of Edarbi have not been established in pediatric patients. Therefore, it is not recommended for use in children and adolescents under the age of 18 years.
  • Renal Impairment: Patients with severe renal impairment may experience increased levels of Edarbi in their bloodstream. Dosage adjustments may be necessary to prevent adverse effects in such individuals.
  • Hepatic Impairment: For patients with moderate to severe hepatic impairment, the use of Edarbi should be undertaken with caution. Monitoring liver function during treatment is essential in such cases.
  • Interactions with Other Medications: Edarbi may interact with other medications, including non-steroidal anti-inflammatory drugs (NSAIDs), lithium, diuretics, potassium supplements, and other antihypertensive agents. Patients should inform their healthcare provider about all the medications they are taking to avoid potential drug interactions.
  • Electrolyte Imbalance: Edarbi may cause changes in electrolyte levels, particularly potassium levels. Regular monitoring of potassium levels is essential, especially for patients with pre-existing electrolyte imbalances.
  • Driving and Operating Machinery: Some patients may experience dizziness, fatigue, or blurred vision while taking Edarbi. If such side effects occur, patients should avoid driving or operating heavy machinery until they know how the medication affects them.
  • Dehydration: Edarbi may increase the risk of dehydration, especially in patients taking diuretics. Patients should stay adequately hydrated and consult their healthcare provider if they experience signs of dehydration.

Side Effects

If you are currently taking Edarbi or considering it as part of your hypertension management plan, it is essential to be informed about the potential adverse effects to make educated decisions about your health.

Common Side Effects of Edarbi

  1. Headache: One of the most prevalent side effects of Edarbi is headaches. This discomfort can be mild to moderate and may occur during the initial days of treatment. Over time, as the body adjusts to the medication, headaches usually subside.
  2. Dizziness: Some individuals may experience dizziness or lightheadedness, especially when rising from a sitting or lying position. This is often a temporary side effect and diminishes as the body adapts to the drug.
  3. Fatigue: Feeling tired or fatigued is another common side effect associated with Edarbi. Patients might notice a decrease in energy levels, but this usually improves over time.
  4. Nausea: Edarbi may cause mild nausea in some individuals. Taking the medication with food or as directed by a healthcare professional can help alleviate this symptom.
  5. Diarrhea: Loose stools or diarrhea might occur as the body adjusts to Edarbi. Staying hydrated and consuming a balanced diet can help manage this side effect.
  6. Cough: A dry, persistent cough is a known side effect of Edarbi. If the cough becomes bothersome, patients should inform their healthcare provider.
  7. Back Pain: Some individuals may experience mild to moderate back pain while taking Edarbi. Gentle stretching exercises and maintaining good posture can help alleviate discomfort.

Rare Side Effects of Edarbi

  1. Allergic Reaction: In rare cases, individuals may experience an allergic reaction to Edarbi. Symptoms may include rash, itching, swelling, severe dizziness, or difficulty breathing. Emergency medical attention is essential in such situations.
  2. Elevated Blood Potassium Levels: Edarbi can lead to increased levels of potassium in the blood (hyperkalemia). This can be especially concerning for individuals with pre-existing kidney problems.
  3. Angioedema: Although rare, Edarbi may cause angioedema, a condition characterized by swelling of the face, lips, throat, or tongue. This can be life-threatening and requires immediate medical attention.
  4. Liver Problems: In some instances, Edarbi has been associated with liver function abnormalities. Regular monitoring of liver enzymes may be necessary during treatment.
  5. Low Blood Pressure: While Edarbi is used to lower blood pressure, in some cases, it may lead to excessively low blood pressure (hypotension). This can cause dizziness, fainting, or falls.
  6. Eye Problems: Some individuals may experience eye-related issues such as blurred vision or dry eyes while taking Edarbi.

Severe Side Effects of Edarbi

  1. Cardiovascular Events: Edarbi, like other blood pressure medications, may be associated with a small risk of cardiovascular events such as heart attack or stroke, especially in individuals with pre-existing heart conditions.
  2. Kidney Problems: In rare cases, Edarbi can cause or worsen kidney problems, leading to decreased kidney function.
  3. Fetal Harm: Edarbi is not recommended for use during pregnancy, as it may cause harm to the fetus. Pregnant women or those planning to become pregnant should consult their healthcare provider for alternative treatments.
  4. Severe Allergic Reactions: In rare instances, Edarbi can trigger severe allergic reactions that require immediate medical intervention.
  5. Intestinal Swelling (Mesenteric Angioedema): Edarbi has been linked to a rare condition called mesenteric angioedema, which involves swelling in the intestines. This condition can be severe and requires prompt medical attention.
  6. Impaired Liver Function: Severe liver problems may occur in very rare cases, necessitating immediate medical attention.

Interactions

As with any medication, understanding its interactions with other drugs, herbs, and foods is crucial to ensure safety and effectiveness.

Drug Interactions

  • Beta-Blockers: Combining Edarbi with beta-blockers can enhance its antihypertensive effects. However, this combination may also increase the risk of hypotension (low blood pressure). Close monitoring by your healthcare provider is advised.
  • Diuretics: Edarbi may interact with diuretics, leading to an additive hypotensive effect. If you are prescribed diuretics along with Edarbi, your doctor will need to carefully adjust the dosages to prevent any adverse reactions.
  • NSAIDs: Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen may diminish the antihypertensive effects of Edarbi. Inform your doctor if you need to take NSAIDs for a specific condition, as an alternative medication might be considered.
  • Lithium: The combination of Edarbi and lithium, often used to treat bipolar disorder, may increase lithium levels in the blood. Regular blood tests and close monitoring are necessary to prevent lithium toxicity.

Herbal Interactions

  • Licorice: Licorice root contains glycyrrhizin, which can lower potassium levels and may lead to hypokalemia when combined with Edarbi. Hypokalemia can increase the risk of arrhythmias and other cardiovascular issues.
  • St. John’s Wort: St. John’s Wort is a popular herbal remedy for depression. When used concurrently with Edarbi, it may reduce the medication’s effectiveness in lowering blood pressure.
  • Garlic: Garlic supplements may have mild antihypertensive effects, and when combined with Edarbi, it can cause excessive blood pressure lowering, leading to hypotension.

Food Interactions

  • Grapefruit: Grapefruit and its juice contain compounds that can interfere with drug metabolism enzymes, potentially increasing the levels of Edarbi in the bloodstream. Avoid consuming grapefruit while taking this medication.
  • High-Potassium Foods: Edarbi can lead to increased potassium levels. It is advisable to avoid or limit high-potassium foods like bananas, oranges, spinach, and tomatoes to prevent hyperkalemia.
  • Alcohol: Combining alcohol with Edarbi may cause excessive drowsiness and dizziness. It can also increase the risk of orthostatic hypotension, a sudden drop in blood pressure when standing up.

Dosing

Understanding the appropriate dosage for Edarbi is crucial to ensure its therapeutic benefits and avoid any potential adverse effects.

Initial Dosage for Edarbi

The initial dosage of Edarbi is generally 80 mg once daily. This starting dose is often sufficient for most individuals to manage their blood pressure effectively. The medication is typically administered orally with or without food. Remember that individual responses to medications may vary, so your healthcare provider might adjust the initial dosage based on your specific condition and medical history.

Maintenance Dose for Edarbi

After initiating treatment with Edarbi, the maintenance dose is usually 80 mg to 160 mg once daily. This dose range allows healthcare providers to tailor the treatment to each patient’s unique needs. It is crucial to adhere to the prescribed maintenance dose consistently to maintain stable blood pressure levels. Regular follow-ups with your doctor will help monitor your response to the medication and make any necessary adjustments.

Missed Dose of Edarbi

If you forget to take a scheduled dose of Edarbi, don’t panic. It’s essential to maintain consistency in taking Edarbi to ensure its effectiveness in controlling blood pressure. Follow these simple steps to manage a missed dose:

  1. If It’s Been Less Than 12 Hours: Take the missed dose as soon as you remember. However, if it is nearly time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule.
  2. If It’s Been More Than 12 Hours: Skip the missed dose altogether and wait until your next scheduled dose. Never take a double dose to make up for the missed one, as it may increase the risk of adverse effects.

Overdose of Edarbi

An overdose of Edarbi can be dangerous and requires immediate medical attention. Symptoms of an overdose may include severe dizziness, fainting, rapid or irregular heartbeat, and difficulty breathing. If you suspect an overdose or experience any severe symptoms, seek emergency medical assistance immediately.

Storage

Properly storing Edarbi is crucial to ensure its efficacy and safety.

  • Recommended Storage Conditions: To maintain the potency and effectiveness of Edarbi, it’s crucial to store it under proper conditions. Store the medication at room temperature, away from direct sunlight, moisture, and heat. Avoid storing it in the bathroom or kitchen, where humidity and temperature fluctuations are common.
  • Proper Container and Packaging: Keep Edarbi in its original container or packaging provided by the pharmacist. The container is designed to protect the medication from external elements and maintain its stability.
  • Room Temperature Storage: Store Edarbi at room temperature, ideally between 68°F to 77°F (20°C to 25°C). Avoid exposing the medication to temperatures outside this range, as it may lead to the degradation of active ingredients.
  • Avoiding Temperature Extremes: Avoid extreme temperatures, both hot and cold, as they can negatively affect the medication’s efficacy. Do not leave Edarbi in a car during hot summer days or expose it to freezing temperatures in winter.
  • Storing Edarbi in a Refrigerator: If you live in a region with high temperatures, consider storing Edarbi in the refrigerator. However, ensure that the medication is not exposed to freezing temperatures, as it can alter the drug’s chemical composition.
  • Protecting from Light and Moisture: Edarbi should be stored in a container that protects it from light and moisture. Exposure to light and moisture can lead to the breakdown of the medication, reducing its effectiveness.
  • Avoiding Exposure to Air: When using Edarbi, make sure to close the container tightly after each use. Exposure to air can cause oxidation of the drug, leading to degradation and reduced efficacy.
  • Keeping Edarbi Away from Children and Pets: Keep Edarbi out of reach of children and pets. The medication is intended for adult use only and can be harmful if ingested accidentally.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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