People with thrombocythemia may be prescribed Agrylin. Thrombocythemia is a blood disorder in which too many platelets are manufactured in the blood, which can lead to blood clots. Agrylin, which may also be known by the generic name anagrelide, blocks the production of blood platelets, lowering them to a safer level in the patient’s bloodstream.

Agrylin Precautions and Warnings

Tell your doctor if you know of any allergies before taking Agrylin. You should share your medical history, especially heart, lung, kidney, or liver problems. It would be best to let your doctor know all the medications you are taking.

Because Agrylin can make you dizzy, you should avoid activities or substances that can also make you dizzy, such as alcohol or cannabis. You should also limit driving, using other heavy machinery, or any other activities requiring your alert, full attention until you know how Agrylin makes you feel.

QT prolongation, also known as Long QT syndrome, is a heart condition affecting the rhythm of heartbeats. Agrylin can cause this syndrome.

This syndrome is named for the QT interval, the name for the electrical impulses in the lower ventricles of the heart. These Q&T waves cause the heart to contract and then refill with blood. When this process takes longer than usual, that is QT prolongation.

This syndrome causes heart arrhythmias that can lead to fainting or seizures in rare cases – this merits immediate medical attention.

Your risk of Long QT Syndrome can be worsened by certain medical conditions such as specific heart problems, including QT prolongation in the EKG, heart failure, or slow heartbeat, or a family history of particular heart problems, including sudden cardiac death or QT prolongation in the EKG. Another risk factor is low levels of potassium or magnesium in the blood. If you use diuretics or you have conditions including severe sweating, diarrhea, or vomiting, talk to your doctor before taking Agrylin.

Before undergoing any surgical procedure, you must inform your doctor or dentist about any medications you take, including prescription or non-prescription drugs and herbal products.

Older adults may experience greater sensitivity to the side effects of this drug, especially symptoms involving QT prolongation (as mentioned above).

If you are pregnant, this medication should only be used if necessary.

Because medicine studies are not performed on pregnant women or babies, doctors don’t know if this medication passes into your breast milk. As a precaution, it is advised that you do not breastfeed while taking this medication or for up to one week after the last dose. It is recommended that you consult with your doctor before breastfeeding.

Side Effects of Agrylin

Mild Side Effects

  • Headache
  • Diarrhea
  • Weakness
  • Nausea
  • Gas
  • Dizziness
  • Loss of Appetite

Serious Side Effects

  • Unusual bleeding
  • Unusual bruising
  • Black stools
  • Foot/ankle swelling
  • Rapid breathing
  • Difficulty breathing
  • Stomach or abdominal pain
  • Fatigue
  • Kidney problems
  • Vomit that looks like coffee grounds

Very Serious Side Effects

  • Chest/jaw/left arm pain
  • Confusion or mental changes
  • Severe dizziness
  • Fainting
  • Fast, irregular, or pounding heartbeat
  • Seizures
  • Trouble speaking
  • Vision changes
  • Weakness on one side of the body


Signs of a severe allergic reaction include rash, itching, swelling of your face, neck, or throat, severe dizziness, or trouble breathing.

People taking Agrylin should contact a medical professional promptly if they experience severe side effects or the symptoms of an allergic reaction.

Agrylin Drug Interactions

It is essential to be aware of drug interactions as they can affect how your medications function and the possibility that they may increase the risk of severe side effects. However, this document may not include all possible drug interactions. Therefore, it is recommended to maintain a list of all the products you use, such as prescription/non-prescription drugs and herbal products, and share the list with your doctor and pharmacist. It is crucial to start, stop, or modify the dosage of any medication with your doctor’s approval.

Some products may interact with this drug, including other medicines that may cause bleeding or bruising (such as antiplatelet drugs like Plavix and “blood thinners” such as Warfarin and Xarelto.

It is essential only to take aspirin if your doctor approves its usage. If you have a high risk for bleeding, aspirin and Agrylin combined can increase this risk.

Discuss the risks and advantages of all of the drugs you are taking with your doctor and pharmacist to be sure you are aware of the possibilities.

Agrylin Strengths and Dosages

.5 mg4 times a day
1 mg2 times a day


The recommended adult starting dose is usually taken twice daily for at least seven days. Your doctor will check on your platelet count and gradually increase the dose until you reach an effective dose. Only change the dose after consulting your doctor.

Agrylin Frequently Asked Questions

What are alternatives to Agrylin?

Hydroxyurea and aspirin are both alternatives to taking Agrylin.

Is this used for chemotherapy?

No, though it is used for some patients with blood cancer, Agrylin is not a chemotherapy medication.

Is anagrelide (Agrylin) in the anticoagulant category?

No, it is an antiplatelet medication.

Can I get anemia if I take Agrylin?

It is a possible but uncommon side effect.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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