Lupron Depot (Leuprolide Acetate)
Lupron Depot is a prescription hormone therapy injection used for certain gynecology indications, including endometriosis and short-term preoperative management of anemia caused by uterine fibroids (formulation-dependent). It is given by a healthcare professional as an intramuscular depot injection and is not a self-injection product.
We only dispense medications with a valid prescription from a licensed prescriber.
All prescriptions are reviewed and verified before dispensing. Orders may be delayed or declined if prescription details are missing, do not match the patient information on file, appear altered, or are expired. We may also refuse service if we believe an order is intended for resale or redistribution.
What You Receive
- Lupron Depot in sealed manufacturer packaging
- Personalized prescription instructions based on your prescriber’s directions
- Medication information leaflet provided by the manufacturer
- Itemized invoice detailing your order
- Rx Required
From $249.95 – $2,200.00
Shipping & Delivery
- Shipped from licensed pharmacy partners
- Tracking information is provided once your order ships
Delivery times may vary based on location and prescription verification.
This page is for general information only and is not medical advice. For medical questions, please speak with your prescriber. See Sources & Methodology for how this information is reviewed and referenced.
Lupron Depot Key Facts
What Lupron Depot is
Lupron Depot is a GnRH agonist (gonadotropin-releasing hormone agonist) depot injection containing leuprolide acetate.
What it’s used for
Endometriosis symptom management (including pain relief and reduction of endometriotic lesions)
Endometriosis treatment with norethindrone acetate add-back therapy (as directed)
Preoperative hematologic improvement in women with anemia caused by fibroids (with iron therapy, when hormonal suppression is needed)
How it works
Lupron Depot first causes a short hormone stimulation, then suppresses pituitary gonadotropins over time, which lowers gonadal steroid hormone levels. This reduces hormone-driven activity in tissues involved in conditions such as endometriosis and fibroids.
Lupron Depot Safety Overview
Lupron Depot can cause important safety issues that should be reviewed before treatment starts, especially because treatment duration and formulation selection matter.
Lupron Depot Warnings & Precautions
Risks and precautions may also differ if it is used with norethindrone acetate add-back therapy.
Do not use Lupron Depot if:
- You have a known allergy to leuprolide, GnRH, or GnRH agonist medicines
- You are pregnant
- You have undiagnosed abnormal uterine bleeding
- Your prescriber has told you you should not take norethindrone acetate and your treatment plan includes add-back therapy
Key warnings to know
- Bone mineral density loss can occur and treatment duration is limited
- Fetal harm risk if used during pregnancy
- Non-hormonal contraception may still be needed because ovulation suppression does not guarantee contraception
- Severe skin reactions (including SCARs) have been reported
- Serious allergic reactions, including anaphylaxis, have been reported
- Symptoms may briefly flare after the first dose
- Depression may occur or worsen during treatment
Side Effects and When to Get Help
Side effects can vary by indication, dose schedule, and whether add-back therapy is used. Many side effects are manageable, but some symptoms need urgent medical attention right away.
Possible side effects may include
- Hot flashes and sweating
- Headache or migraine
- Mood changes
- Vaginal symptoms (such as irritation or dryness)
- Nausea or vomiting
- Dizziness
- Changes in libido
- General body pain
- Weight changes
- Injection site irritation
Get urgent help right away for
- Signs of a serious allergic reaction (swelling, trouble breathing, severe hives)
- Severe rash or skin reaction, especially with fever, mouth sores, or peeling skin
- Seizure symptoms
- Severe depression symptoms or thoughts of self-harm
- Signs of pregnancy during treatment
- Severe or unusual symptoms that rapidly worsen after an injection
Interactions
Lupron Depot does not have formal pharmacokinetic drug-drug interaction studies in the 11.25 mg gynecology label, and CYP450-mediated interactions are not expected based on how leuprolide is handled. Even so, your prescriber should review your full medication list and any add-back therapy plan before treatment.
Interactions you should discuss with your prescriber include
- Norethindrone acetate (if used as add-back therapy)
- All prescription medicines, OTC medicines, vitamins, and supplements
- Medicines that may affect bone health (for example long-term corticosteroids)
- Medicines used for seizure disorders
- Hormonal therapies or hormone-containing products unless specifically approved by your prescriber
Lupron Depot Drug Facts
| Category | Details |
|---|---|
| Brand Name | Lupron Depot |
| Drug Class | GnRH agonist |
| Indication | Endometriosis; selected fibroid-related preoperative anemia use (with iron), depending on formulation |
| Dosage Forms | Depot suspension for IM injection (reconstituted) |
| Strengths | 3.75 mg (1-month), 11.25 mg (3-month) gynecology formulations |
| Administration Timing | Given by a healthcare professional; monthly (3.75 mg) or every 3 months (11.25 mg), depending on indication |
| Key warnings | Pregnancy, undiagnosed abnormal uterine bleeding, hypersensitivity to GnRH/GnRH agonists/leuprolide; add-back therapy contraindications also apply when used |
| Storage | Store kit at 20°C to 25°C (68°F to 77°F); excursions 15°C to 30°C (59°F to 86°F) |
| Missed Dose | Clinic injection; if an appointment is missed, contact the clinic/prescriber promptly to reschedule |
| Alternatives | Leuprolide depot (formulation-dependent), Zoladex (goserelin), Orilissa (elagolix), Myfembree (indication-specific) |
Helpful Information
How To Buy Lupron Depot Online
1
Select Your Prescribed Lupron Depot Dosage & Strength
Choose the strength and quantity that matches your prescription, then add it to your cart. Orders are limited to a 90-day supply per fill.
2
Complete Checkout
Ensure your shipping and contact information is correct so your order can be processed without delays.
3
Submit Your Lupron Depot Prescription
Upload your prescription at checkout. If you need a transfer, provide your prescriber or current pharmacy details and we will request it on your behalf.
Prescription & Dispensing Standards
- Prescription required for all orders and reviewed for pharmacy and regulatory compliance
- Dispensed by licensed pharmacy partners
- Orders are held if information is missing, unclear, or does not match.
- No substitutions without prescriber approval, and no controlled substances.
Our Guarantee
At MyRx Outlet, we are committed to delivering safe, high-quality medications that you can trust. We adhere to strict regulations in every country we operate in, ensuring that your order is handled by a licensed Canadian pharmacy or a trusted partner overseas. Each medication has been legally approved by Health Canada or other respected authorities. To purchase Lupron Depot at a discounted rate, call 1-888-551-2467.
FAQs
What is Lupron Depot used for?
Lupron Depot is used for certain hormone-responsive gynecology conditions, including endometriosis and selected short-term fibroid-related treatment plans before surgery (depending on the exact formulation and treatment plan).
How often is Lupron Depot given?
It depends on the formulation. Common gynecology versions are given either once monthly (3.75 mg) or once every 3 months (11.25 mg), and they are not interchangeable.
Does Lupron Depot stop periods?
It commonly suppresses ovulation and menstruation during treatment, but this does not guarantee contraception. If pregnancy prevention is needed, non-hormonal contraception may be recommended.
What are the most common side effects of Lupron Depot?
Commonly reported effects include hot flashes/sweats, headaches, mood changes, vaginal symptoms, nausea/vomiting, dizziness, libido changes, pain, and weight changes.
How long can you stay on Lupron Depot?
Treatment duration is limited because of bone mineral density loss risk. The exact limit depends on indication and whether add-back therapy is used, so duration should be set by the prescriber.
Ordering & Prescription FAQs
Do I need a prescription?
Yes, a prescription is required. Refills depend on what your prescriber authorizes.
How do I submit my prescription?
You can upload it through our Upload Prescription page, email it to info@myrxoutlet.com, or fax it to 1-888-230-1245. If you need a prescription transfer, just let us know at checkout and include your pharmacy or prescriber contact details.
When is my payment processed?
Your payment is processed only after your prescription and order have been reviewed and approved by our licensed pharmacy team. Once everything is confirmed, we’ll process payment and prepare your order for shipping.
What happens if my prescription can’t be verified?
Your order may be placed on hold or declined if prescription details are missing, don’t match, are expired, or can’t be confirmed.
Sources
FDA Prescribing Information / Patient Information, LUPRON DEPOT 11.25 mg (leuprolide acetate for depot suspension for injection)
https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/020708s040s041lbl.pdf
DailyMed Drug Label, LUPRON DEPOT 11.25 mg (leuprolide acetate kit)
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=60aad237-e1da-4705-cbbb-b3ca79e89ad8
DailyMed Drug Label, LUPRON DEPOT 3.75 mg (leuprolide acetate kit)
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=00c486b0-bd7b-4898-834d-8c656e5e73cb