This is a prescription medication that is used to treat advanced prostate cancer, uterine fibroids, or endometriosis as well as other problems related to female hormones. There is another form of this drug used in pediatric patients called Lupron Depot-Ped. When it’s given to children, it’s for early-onset puberty. Lupron Depot in both forms has an active ingredient called leuprolide acetate. It’s a type of hormone therapy that is in a group of medications that are known as gonadotropin-releasing hormone agonists.

This medication is administered as an injection only. A healthcare practitioner will inject you with Lupron Depot. It is injected straight into a muscle.

Lupron Depot is a synthetic protein that acts like a natural hormone. When given to men, it decreases the amount of testosterone. When given to women, it decreases the amount of estrogen. When given to a child, it can help both males and females with precocious puberty in those aged two and up. This medication gained FDA approval in 1985.

Lupron Depot Precautions and Warnings

It’s essential for your doctor to know your complete health history before you take this medication. Be sure that they know about any health conditions you have. If you’ve ever been allergic to this medication, don’t take it. Tell the doctor about the reaction right away.

When used long-term, this medication can cause patients to develop lower bone density. If you have osteoporosis or anything else resulting in bone density loss, ensure your doctor knows about it. Drinking alcohol can make this effect worse. You may need to have bone density testing while you’re using this medication, or you might be put on a different medication.

It’s possible for this medication to cause depression. If you have existing depression, taking Lupron Depot can make it worse. If you have depression, tell your doctor before taking this medication. You may need close monitoring while using this drug. Be aware of any unusual or new behaviors or moods.

Lupron Depot can cause your blood sugar to go up. If you’re diabetic, this can make your condition worse or make it harder to keep control over it. Tell your doctor if you are diabetic before going on this drug. You’ll need to check your blood sugar more often, and you may need your diabetes medication dosage to be changed. If you don’t have diabetes, this medication can make it more likely that you’ll develop it.

This medication can cause problems with blood vessels and the heart, including strokes or heart attacks. Patients who have existing heart problems, particularly if they have a heart rhythm problem, need to tell the doctor about their condition. The doctor will weigh the risks of taking this medication against its benefits.

This medication shouldn’t be used during pregnancy. It can put you at a higher risk of pregnancy loss and can cause harm to the baby. You’ll need a pregnancy test before you take this medication. Take precautions not to become pregnant while taking it. It’s also important not to breastfeed while using this medication, as it may be harmful to the baby.

Side Effects of Lupron Depot

There are a number of side effects possible, and they may be mild or more severe. Sometimes, a patient will have their side effects go away once their body gets used to the medication after taking it for a couple of weeks.

Some of these side effects may be severe or bothersome. If your side effects bother you, tell your doctor about the problem. You may need to have your dosage changed or to be switched to a different medication.

Common Side Effects

Some of the common side effects of this medication include:

  • Decrease in testicle size
  • Menstruation or spotting
  • Hot flashes, clamminess, or sweating
  • Fatigue
  • Vaginal itching, dryness, or discharge
  • Swelling of the lower legs, feet, hands, or ankles
  • Pain or tenderness in the breast or a changed breast size in women and men
  • Less sexual desire and ability
  • Stomach pain
  • Depression
  • Joint or muscle pain
  • Feet or hands that tingle, burn, or hurt
  • Weight changes
  • Fever
  • Acne
  • Constipation
  • Nervousness
  • Sore throat, cough, runny nose, or flu-like effects
  • Injection site redness, pain, redness, burning or hardening
  • Memory problems
  • Moon changes and difficulty controlling emotions
  • Feeling uneasy or uncomfortable
  • Rash
  • Fluid retention

Allergic Reaction

It’s possible to have an allergic reaction to this medication. This may be mild or severe. If you have minor itchiness, skin rash, or flushing, these are mild symptoms, but the doctor should hear about them. If you have a severe reaction, you may have trouble breathing, and swelling in your face, hands, feet, or in your mouth.

Drug Interactions with Lupron Depot

There are several medications that can cause a bad interaction with Lupron Depot. Don’t take this medication along with cisapride, pimozide, chasteberry, thioridazine, or dronedarone (Multaq). Lupron Depot may also interact with certain dietary or herbal supplements such as DHEA or black cohosh as well as male or female hormones or medications that can create an abnormal heart rhythm called a QT interval.

Strengths and Dosages of Lupron Depot

Both Lupron Depot and Lupron Depot-Ped are available in syringes. A powder is mixed into a solution by a healthcare provider. The patient is then given the injection. There are different strengths available for this medication. These include 3.75 mg, 7.5 mg, 11.25 mg, 15 mg, 22.5 mg, 30 mg, and 45 mg.

When this medication is administered for advanced prostate cancer, it’s usually given in one dose every one, three, four, or six months. When it’s administered for uterine fibroids or endometriosis, it’s usually even every month or three months. When it’s given for early-onset puberty, it’s generally given every month or three months.

Lupron Depot injections:3.75 mg, 7.5 mg, 11.25 mg, 15 mg, 22.5 mg, 30 mg, 45 mg

Cost of Lupron Depot in America

A monthly injection costs about $2,400. The exact price will depend on the strength of the injection that you’re given. If you have health insurance, there may be a much lower price that you’ll pay such as a negotiated price or a co-pay. The manufacturer of this medication, AbbVie, also has a program to help people with their medications if they can’t afford them. The program is called myAbbVie Assist.

FAQs of Lupron Depot

What is Lupron Depot used for?

This is a medication that can be used to treat advanced prostate cancer as well as hormone problems in women such as endometriosis and uterine fibroids.

How long does Lupron Depot stay in your system?

This drug has many strengths available, and how long it lasts depends on the strength used. The medication is a long-acting type that can last until the next dose which may be a month or more away. The six-month strengths slowly release the medication for six months.

How does Lupron Depot work?

This medication acts like a natural hormone, affecting how much estrogen or testosterone is made by the body. It generally reduces the production of those hormones to treat the problem caused by hormones, including advanced prostate cancer.

Who makes Lupron Depot?

The manufacturer is AbbVie.

Will I have withdrawal symptoms when I stop taking Lupron Depot?

No, because this medication is so long-acting, the medication will stay in your system for a long while after you stop taking it. Once it is eliminated from your system, your hormone levels will go back to what they were before you started taking this medication.

How to store Lupron Depot?

It is stored in medical facilities and is kept as a powder and a separate solution until it is to be administered. Then, the two parts are combined to create the medication.

Can you drink alcohol while taking this medication?

It’s not a good idea to drink alcohol while using this medication. One of its possible side effects is lowering bone density, and alcohol can make this effect worse.

Are there alternatives to Lupron Depot?

Lupron may be an alternative for Lupron Depot, though it isn’t as long acting. There are also other medications that can be tried for various uses, including Erleada, Bicalutamide, Zytiga, Apalutamide, Casodex, Eligard, and Xtandi.

Who injects Lupron Depot for me?

This medication is injected by a healthcare professional. You won’t be given these syringes to take home and inject by yourself. It’s injected into a muscle.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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