Humatin, also known by its generic name paromomycin, is an antibiotic medication used to treat various intestinal infections. It is primarily prescribed for the treatment of amebiasis, a parasitic infection caused by a protozoan parasite called Entamoeba histolytica. This medication is also effective against other types of intestinal infections, such as giardiasis and cryptosporidiosis.

Warnings and Precautions

While it can be an effective treatment option, it is important to be aware of the warnings and precautions associated with its use.

Allergic Reactions

Humatin may cause allergic reactions in some individuals. It is essential to be vigilant for any signs of an allergic reaction, such as hives, itching, rash, swelling, or difficulty breathing. If you experience any of these symptoms after taking Humatin, seek immediate medical attention and discontinue the medication.

Drug Interactions

Before starting Humatin, inform your healthcare provider about all the medications you are currently taking. Certain drugs may interact with Humatin and lead to adverse effects. In particular, let your doctor know if you are taking any blood-thinning medications, as combining them with Humatin may increase the risk of bleeding.

Pregnancy and Breastfeeding

If you are pregnant or planning to become pregnant, it is crucial to discuss the potential risks and benefits of using Humatin with your healthcare provider. While Humatin is generally considered safe during pregnancy, it should only be used if the potential benefits outweigh the risks.

Similarly, if you are breastfeeding, consult your doctor before taking Humatin. The medication can pass into breast milk and may harm the nursing infant. Your healthcare provider can guide you on the appropriate course of action based on your specific situation.

Pediatric Use

Humatin can be prescribed to children for certain infections, but the dosage and duration of treatment may vary based on their age and weight. It is important to follow your doctor’s instructions carefully and monitor your child for any signs of adverse effects. If you have any concerns, reach out to your child’s healthcare provider for clarification.

Gastrointestinal Side Effects

One common side effect of Humatin is gastrointestinal discomfort. This may include symptoms such as nausea, vomiting, diarrhea, or stomach pain. To minimize these effects, take Humatin with food or milk. If the symptoms persist or worsen, consult your healthcare provider for further guidance.

Sun Sensitivity

Humatin can make your skin more sensitive to sunlight. It is essential to take precautions when going outdoors, such as wearing protective clothing and using sunscreen with a high sun protection factor (SPF). Avoid prolonged sun exposure and tanning beds while taking Humatin to prevent sunburn and skin damage.

Liver and Kidney Function

If you have pre-existing liver or kidney conditions, it is crucial to inform your healthcare provider before starting Humatin. The medication can affect these organs, and your doctor may need to adjust the dosage or monitor your liver and kidney function during treatment.

Resistance and Recurrence

Humatin is an antibiotic, and like other antibiotics, its inappropriate use can contribute to the development of bacterial resistance. It is crucial to complete the full course of treatment as prescribed by your healthcare provider, even if your symptoms improve before the treatment period ends. Skipping doses or stopping the medication prematurely may lead to the recurrence of the infection and reduce the effectiveness of Humatin in the future.

Side Effects

While it is generally effective in combating these infections, like any medication, Humatin can also have side effects. It is important to be aware of these potential side effects before starting treatment with Humatin.

Common Side Effects

  • Nausea and Vomiting: One of the most common side effects of Humatin is nausea, which may be accompanied by vomiting. These symptoms can usually be managed by taking the medication with food or milk. If the nausea and vomiting persist or become severe, it is important to consult your healthcare provider.
  • Diarrhea: Humatin can sometimes cause diarrhea, which may range from mild to severe. It is essential to stay hydrated and replenish electrolytes while experiencing diarrhea. If the diarrhea persists or is accompanied by abdominal pain or fever, medical attention should be sought.
  • Loss of Appetite: Some individuals may experience a decreased appetite while taking Humatin. It is important to maintain a healthy diet and ensure adequate nutrition during this time. If the loss of appetite persists and leads to significant weight loss or weakness, consult your healthcare provider.
  • Abdominal Discomfort: Humatin can cause abdominal discomfort, such as cramps or bloating. These symptoms are usually mild and transient, resolving on their own. However, if the discomfort becomes severe or is accompanied by other concerning symptoms, medical advice should be sought.
  • Headache: Another common side effect of Humatin is a headache. This symptom is typically mild and temporary. If the headache becomes severe or persistent, it is advisable to consult your healthcare provider.


Rare Side Effects

  • Allergic Reactions: Although rare, some individuals may develop an allergic reaction to Humatin. Signs of an allergic reaction may include rash, itching, swelling, severe dizziness, or difficulty breathing. If any of these symptoms occur, immediate medical attention is necessary.
  • Liver Problems: In rare cases, Humatin can cause liver problems. Symptoms may include yellowing of the skin or eyes (jaundice), dark urine, pale stools, or persistent abdominal pain. If you experience any of these symptoms, it is important to seek medical help promptly.
  • Blood Disorders: Humatin can rarely affect blood cells, leading to conditions such as anemia or a decrease in white blood cells. Symptoms of these blood disorders may include unusual tiredness, pale skin, easy bruising or bleeding, or signs of infection. If any of these symptoms occur, consult your healthcare provider immediately.
  • Neurological Effects: Although uncommon, Humatin can cause neurological side effects in some individuals. These effects may include dizziness, confusion, or difficulty with coordination. If you experience any of these symptoms, it is advisable to seek medical advice.
  • Muscle or Joint Pain: In rare cases, Humatin may cause muscle or joint pain. If you develop unexplained muscle or joint pain while taking Humatin, it is important to inform your healthcare provider.


Severe Side Effects

  • Severe Allergic Reaction (Anaphylaxis): While extremely rare, Humatin can trigger a severe allergic reaction known as anaphylaxis. This is a medical emergency and requires immediate attention. Symptoms of anaphylaxis may include difficulty breathing, swelling of the face, lips, tongue, or throat, rapid heartbeat, or loss of consciousness.
  • Pancreatitis: In very rare instances, Humatin may cause inflammation of the pancreas (pancreatitis). Symptoms of pancreatitis may include severe abdominal pain, nausea, vomiting, and fever. If you experience these symptoms, seek medical assistance urgently.
  • Vision Changes: Although uncommon, Humatin can cause vision changes in some individuals. If you notice any alterations in your vision while taking this medication, it is important to notify your healthcare provider.
  • Kidney Problems: Severe kidney problems are rare but possible with the use of Humatin. Symptoms of kidney problems may include decreased urine output, swelling in the legs or ankles, fatigue, or shortness of breath. If you experience these symptoms, it is crucial to seek medical help immediately.


Drug Interactions

By understanding the possible interactions with other medications, you can take appropriate precautions and minimize any potential risks.

Aminoglycoside Antibiotics

Combining Humatin with other aminoglycoside antibiotics, such as streptomycin or neomycin, can increase the risk of kidney damage. It’s important to monitor kidney function closely when using these medications together.

Certain Anticoagulants

Humatin may interact with anticoagulant medications, such as warfarin, and alter their effects. This interaction can increase the risk of bleeding. Regular monitoring of blood clotting parameters is crucial if Humatin is used concomitantly with anticoagulants.

Muscle Relaxants

Concurrent use of Humatin and certain muscle relaxants, like succinylcholine, can enhance the muscle relaxant effects, potentially leading to increased respiratory depression. Caution should be exercised when combining these medications.

Medications That Affect the Neuromuscular Junction

Humatin can interact with medications that affect the neuromuscular junction, such as botulinum toxin. This interaction may potentiate the effects of both drugs, resulting in increased muscle weakness or paralysis. Close monitoring is necessary in such cases.

Nephrotoxic Medications

Humatin should be used cautiously in combination with other nephrotoxic medications, as it can increase the risk of kidney damage. Regular monitoring of renal function is essential when using these medications together.


Following the recommended dosing guidelines is essential for achieving optimal results. Remember to take Humatin as prescribed by your healthcare provider, adhere to the recommended dosage, and consult your doctor if you have any concerns or questions.

Recommended Dosage for Adults

For adults, the usual recommended dosage of Humatin is 25 to 35 mg per kilogram of body weight per day, divided into three equal doses. This means that if you weigh 70 kilograms, the total daily dosage would range from 1750 mg to 2450 mg, depending on your specific condition.

Recommended Dosage for Children

The dosing of Humatin for children is based on their body weight. The usual recommended dosage for pediatric patients is 25 to 35 mg per kilogram of body weight per day, divided into three equal doses.

Missed Dose

If you accidentally miss a dose of Humatin, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.


Taking more than the prescribed dose of Humatin can lead to an overdose. If you suspect an overdose, seek immediate medical attention or contact a poison control center right away. Symptoms of an overdose may include severe stomach pain, vomiting, hearing loss, and difficulty breathing.


  • Follow the instructions on the packaging: Always read and follow the instructions provided on the packaging of Humatin. The manufacturer may provide specific storage guidelines that are essential to maintain the efficacy of the medication. Adhering to these instructions will help preserve the quality of Humatin.
  • Keep away from children and pets: To ensure the safety of children and pets, store Humatin in a location that is out of their reach. Consider using child-resistant containers or storing the medication in a locked cabinet to prevent accidental ingestion.
  • Check the expiration date: Before storing Humatin, check the expiration date printed on the packaging. Expired medications may not provide the desired therapeutic effect and can even be harmful. Dispose of any expired Humatin properly and avoid using it beyond the recommended date.
  • Avoid transferring to different containers: Unless explicitly instructed by a healthcare professional or pharmacist, do not transfer Humatin to a different container. The original packaging is designed to protect the medication from external elements, ensuring its stability and potency.
  • Store away from heat sources: Humatin should be stored away from direct sources of heat, such as stoves, radiators, or heating vents. Exposure to high temperatures can alter the chemical composition of the medication and reduce its effectiveness.
  • Store in a cool and dry place: Choose a cool and dry place to store Humatin. The bathroom and kitchen are generally not suitable for medication storage due to their fluctuating temperature and high humidity levels. Instead, opt for a bedroom or a closet that is not exposed to excessive heat or moisture.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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