Humatin, or Paromomycin, is an aminoglycoside antibiotic that fights microorganisms. This drug kills bacteria by preventing protein synthesis.

The FDA approved Humatin to treat intestinal parasites such as amoebiasis, cryptosporidiosis, and giardiasis and cure hepatic coma. Additionally, Humatin treats bacterial infections in the digestive tract.

While Humatin is usually administered orally, other methods might be considered based on individual circumstances. And just like other antibiotics, patients must finish treatment as prescribed to minimize antibiotic resistance and ensure efficacy.

How Does Humatin Work?

Humatin works by inhibiting bacteria and parasite growth by targeting critical cellular processes, promoting the immune system, or other elimination. Here’s how the active ingredient Paromomycin can achieve that:

  • Binding to Ribosomes: Paromomycin binds to ribosomes, which synthesize proteins in bacteria and parasites. Paromomycin disrupts genetic information reading and translation into proteins by attaching to ribosomal subunits. As a result, the bacteria or parasites cannot synthesize crucial proteins for survival and replication.
  • Misreading Genetic Code: Humatin can induce protein synthesis and cause genetic code reading problems. Misreading the mRNA template causes erroneous amino acids to be added to the protein chain. This produces nonfunctional or faulty proteins, affecting bacteria and parasite life and function.
  • Disrupting Cell Membrane Integrity: In addition to disrupting protein production, this drug may also affect bacterial and parasite cell membranes, damaging their structure and killing the cells.

Precautions and Warnings of Humatin

Before administering Humatin, you need to be aware of these precautions and warnings:

  • Bacterial Vaccines: Paromomycin may interfere with the normal function of live bacterial vaccines, making them fail. Discuss with your doctor before taking bacterial vaccines when on Humatin medication.
  • Pregnant and Breastfeeding Women: It is unclear whether Humatin can be secreted in human milk. Similarly, there’s not enough research to determine the safety of the drug on infants and unborn babies. So pregnant and breastfeeding women should only use this drug after discussing possible benefits and risks with a doctor.
  • Allergies: Avoid taking this medication if you’re allergic to paromomycin, its inactive ingredients, or any other aminoglycoside antibiotic, as it may result in severe allergic reactions.
  • Drug Resistance: Only take Humatin for proven bacterial infections. Using the drug without the right bacteria increases the risk of developing drug-resistant bacteria.
  • Inflammatory Bowel Disease: People with ulcerative lesions of the bowel should use Humatin with caution as it could be absorbed inadvertently, leading to renal toxicity.
  • Overgrowth of Organisms: Humatin can effectively kill intestinal parasites and certain bacteria, but it could lead to an overgrowth of non-susceptible organisms like fungi. Notify your doctor if you develop symptoms of other infections during therapy.

Humatin Side Effects

Patients may experience some unwanted effects after taking Humatin. Some of these side effects are mild and disappear after the body has adjusted to the medication. Others are so severe and persistent that your doctor may require you to change the dosage or drop the medication altogether.

Common Side Effects

Most people taking Humatin may experience common side effects like:

  • Dizziness
  • Hives
  • Weakness of the joints of the arm and the legs
  • Sweating on face, tongue, lips
  • Fever
  • Nausea
  • Stomach cramps
  • Diarrhea

Severe Side Effects

Call your doctor immediately if you experience:

  • Sudden loss of vision, eye pain, blurred vision, or swelling of the eye
  • Severe headache
  • Trouble walking, confusion, or loss of coordination
  • Stiffy muscles
  • Fast, irregular heartbeats
  • Shortness of breath

Drug Interactions With Humatin

Interaction of Humatin with other medications can change its effectiveness and intensify the risk of side effects like nausea. Here are the everyday drug interactions you need to be aware of:

Drug Interaction
AnticoagulantHumatin may interact with anticoagulants such as Warfarin and Eliquis and increase the risk of bleeding.
DiureticsUsing Humatin with other types of diuretics increases the likelihood of kidney damage.
AlcoholConsuming alcohol while taking this medication is highly discouraged as it can exacerbate serious side effects like dizziness and abdominal pain.
Aminoglycoside antibioticsConcurrent use of Humatin with aminoglycoside like gentamicin may lead to an increase in nephrotoxicity.
AcenocoumarolCombining the medication with acenocouarol may lead to an increase in bleeding.

Before you use Humatin, you should consult your doctor about potential drug interactions. Inform them of any drugs or vitamins that you might be taking. The doctor should be able to advise you on how possible interactions can be managed without stopping any of the medication.

Humatin Strengths and Dosages

The dosage of Humatin will differ depending on the type and severity of the condition being treated, as well as the patient’s age.

Additionally, the frequency of doses per day, the intervals between doses, and the duration of treatment are determined by a specific medical condition being addressed and the drug’s potency.

Type of Disease Age Dosage No of times a day
Intestinal amebiasisChildren25mgThree times a day (after every 8 hours)
Adults35mgThree times a day (after every 8 hours)
Hepatic comaChildrenIt needs to be determined by the doctor.
Adults4gPer day (small doses)

Humatin Alternatives

Besides Paromomycin, other alternative medications can treat parasites like amoebiasis. They include:

  • Metronidazole (Flagyl)- An antibiotic that prevents bacterial cell replication, leading to its death. This drug is effective against a wide range of infections, including amoebas.
  • Tinidazole– Treats various infections, including trichomoniasis, amebiasis, and giardiasis.
  • Albendazole: Cures parasitic worm infections such as ascariasis, hookworm infection, giardiasis, and pinworm infection.

FAQs of Humatin

If you are a current customer and have questions about Humatin, feel free to contact us, and we can have one of our licensed pharmacists reach out to you.

Is Humatin safe for pregnant or breastfeeding women?

Unless advised by your doctor, do not take Humatin when pregnant or breastfeeding since it is unclear whether the drug can pass through human milk and harm your baby or if it could affect unborn babies.

Should I take paromomycin before or after food?

Humatin should be taken with meals to reduce the risk of stomach upset.

How long does it take for paromomycin to work?

While the time taken for paromomycin to work may vary from one individual to another, most patients experience symptom relief after five days of using the medication.

Can Humatin interact with other medications?

Yes. Humatin can interact with certain medications, altering their effectiveness and sometimes intensifying side effects. It would be essential to let your doctor know about your current medication.

How is Humatin stored?

Store Humatin at room temperature, away from direct sunlight, and out of reach of children and pets. If you have an expired medication, please do not use it; dispose of it correctly according to local regulations.

What are the common side effects of Humatin?

The common side effects include nausea, dizziness, headache, and vomiting. These side effects are mild and temporary, but please seek medical assistance immediately if they continue.

What should I do if I miss a dose?

If you miss the medication, please take it as soon as you remember. But if it is time to take the next dose, you can ignore the missed dose and continue with the regular dosage schedule.

What is the cost of Humatin in America?

250 mg of Humatin is $491 for a supply of 100 capsules.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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