Edarbyclor is a generic drug name for a medication in the angiotensin II inhibitors with thiazides class. The drug is made up of a combination of the angiotensin II receptor blocker azilsartan and a thiazide diuretic called chlorthalidone. Edarbyclor is used to treat high blood pressure and lower the chance of having a stroke or heart attack.

The angiotensin II inhibitor component of Edarbyclor stops the activation of the angiotensin II receptor. This results in vasodilation and a reduction of the antidiuretic hormone vasopressin. It also reduces aldosterone—a steroid hormone that helps regulate the balance of salts and water in the kidneys. The combined effects lead to reduced blood pressure.

The thiazide diuretics component blocks the sodium/chloride co-transporter in the distal convoluted tubule, leading to decreased re-absorption of sodium and chloride ions. This results in increased urine production and lowered blood pressure.

Edarbyclor Precautions and Warnings

Do not take Edarbyclor if you are allergic to any of its ingredients, such as azilsartan or chlorthalidone. Those who are allergic to sulfonamide medications should also not take Edarbyclor.

Talk to your doctor if you are or are planning to become pregnant or breastfeeding. The azilsartan and chlorthalidone components may cause injury or death to the unborn baby. This risk is increased during the second or third trimester.

Edarbyclor should not be used in combination with diabetes medication containing the blood pressure medicine Aliskiren. This medication should also be avoided for those with liver or kidney disease, gout, low sodium or potassium in their blood, heart disease, or history of stroke. It should not also be used by those suffering from dehydration or difficulty urinating.

This medication is not approved for those under 18 years old.

Edarbyclor Side Effects

There are many common and more severe side effects associated with Edarbyclor.

Common Side Effects

  • abdominal pain
  • back or leg pain
  • constipation
  • decreased appetite
  • difficulty with sexual activity
  • diarrhea
  • restlessness and trouble sleeping
  • dizziness
  • dry mouth
  • drowsiness or fatigue
  • headache
  • increased sensitivity to the sun
  • muscle cramps or spasms
  • nausea
  • skin rash or red patches
  • spinning sensation
  • sweating
  • upset stomach
  • weakness

Severe Side Effects

These side effects are uncommon but may occur. If you begin to experience any of these side effects, contact your healthcare provider immediately.

  • increased or irregular heartbeat
  • pins and needles feeling in the fingers
  • anemia
  • bleeding
  • electrolyte imbalance
  • signs of infection
  • kidney problems
  • liver problems
  • low blood pressure
  • muscle damage
  • pancreatitis
  • swelling of the hands and feet
  • puffiness from fluid retention
  • swollen glands
  • high blood sugar

Very Severe Side Effects

You should seek immediate medical attention if you are exhibiting of the signs of a serious allergic reaction. This may include abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face or throat. Other possible reactions that require immediate medical attention include severe skin reactions—such as blistering, peeling, and rashes that may be large, spread rapidly, or are accompanied by fever—or eye problems, such as eye pain, blurred vision, or sudden nearsightedness.

Drug Interactions with Edarbyclor

There are many possible drug interactions with Edarbyclor. Some common drug types with interactions include:

  • Cardiovascular Medications
  • Antihypertensives
  • Antihistamines
  • Respiratory Medications
  • Antipsychotics
  • Antidepressants
  • Stimulants
  • Antiparkinsonian Medications
  • Analgesics
  • Pain Management Medications
  • Endocrine Medications
  • Anti-infectives
  • Immunosuppressants
  • Gastrointestinal Medications
  • Anticonvulsants
  • Mood Stabilizers
  • Anticholinergics
  • Diabetes medications
  • Phosphodiesterase-5 inhibitors
  • Bortezomib
  • Calcipotriol
  • Cyclophosphamide
  • Conivaptan
  • Cyclobenzaprine
  • Digoxin
  • Glycopyrrolate
  • Heparin
  • Low-molecular-weight heparins
  • Potassium supplements
  • Sodium phosphates
  • Calcium supplements
  • Tretinoin
  • Yohimbine
  • Barbiturates
  • Orphenadrine
  • Dextromethorphan
  • Pentoxifylline
  • Flunarizine
  • Tolvaptan
  • Brimonidine
  • Nabilone

Strengths and Dosages of Edarbyclor

The recommended starting dose of Edarbyclor is one 40/12.5 mg tablet taken once daily. This dose may be increased to 40/25 mg after 2 to 4 weeks. The effects of the initial 40/12.5 mg dose should begin to take apparent effect within 1 to 2 weeks.

Cost of Edarbyclor in America?

The average cost for Edarbyclor in America is $8.88 without insurance, depending on the pharmacy.

DoseAmount Price
40/12.5 mg30 Tablets$266.28
40/25 mg30 Tablets$266.28

Why is Edarbyclor So Expensive?

Edarbi is expensive because it is the only angiotensin receptor blocker in the U.S. that does not have a generic equivalent available. This often creates a higher out-of-pocket cost. Additionally, its two active ingredients—azilsartan and chlorthalidone—are both relatively expensive to produce.

Edarbyclor Alternatives

Edarbyclor is available as a brand-name drug only. No generic version is available. However, some alternatives may include:

Edarbyclor FAQs

When is the best time to take Edarbyclor?

Edarbyclor should be taken once daily at consistent times for best results unless otherwise directed by a doctor. The estimated best time of day to take It is at least 4 hours before going to bed, as it may cause the patient to need to wake up to urinate.

Is Edarbyclor a good blood pressure medication?

Edarbyclor is an effective option for blood pressure control. This helps to prevent issues such as strokes, heart attacks, and kidney problems.

Is Edarbyclor hard on kidneys?

Edarbyclor may affect kidney function. Narrowing of the artery to the kidney and sudden kidney failure has been reported in rare cases. Those already facing kidney problems should avoid the use of Edarbyclor.

Can you drink alcohol while taking Edarbyclor?

No, those on Edarbyclor should not consume alcohol as it increases the risk of dangerously low blood pressure.

Does Edarbyclor cause weight gain?

Weight gain may be a symptom of Edarbyclor, but it is uncommon. If you experience weight gain while taking Edarbyclor, contact a doctor, as it is considered a serious side effect and may be a sign of other issues.

Can Edarbyclor increase your heart rate?

Increased heart rate or irregular heartbeat can be side effects of Edarbyclor. If you experience increased heart rate or irregular heartbeat while taking Edarbyclor, seek medical attention immediately, as it could lead to serious problems.

How fast does Edarbyclor work?

Edarbyclor takes effect within a few hours, although these effects may not be felt immediately. More apparent effects should be noticed within within 1 to 2 weeks.

Is there a generic version of Edarbyclor?

No, Edarbyclor is currently only available as a brand-name medication.

Can I take ibuprofen with Edarbyclor?

Taking ibuprofen once in a while for short periods of time is fine for most people on Edarbyclor. Regular use of ibuprofen may be harmful, however, as nonsteroidal anti-inflammatory drugs (NSAIDs) may lead to kidney damage or worsen your blood pressure while on Edarbyclor.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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