Edarbyclor is a combination medication that belongs to a class of drugs called angiotensin II receptor blockers (ARBs) and thiazide diuretics. Azilsartan medoxomil is the ARB component, which works by blocking the action of angiotensin II, a hormone that constricts blood vessels and increases blood pressure. Chlorthalidone, on the other hand, is a thiazide diuretic that helps remove excess fluid from the body, reducing the volume of blood and decreasing blood pressure.

Edarbyclor is primarily used to treat hypertension, or high blood pressure, in adults. High blood pressure is a common medical condition that occurs when the force of blood against the walls of the arteries is consistently too high. If left untreated, high blood pressure can lead to serious health complications, including heart disease, stroke, and kidney problems.

By combining azilsartan medoxomil and chlorthalidone, Edarbyclor offers a dual mechanism of action to effectively lower blood pressure. It relaxes and widens the blood vessels, allowing blood to flow more freely, while also reducing the amount of fluid in the body. This combination helps to achieve and maintain optimal blood pressure levels, reducing the risk of cardiovascular events and related complications.

Edarbyclor works by targeting two key factors involved in hypertension: vasoconstriction and fluid retention. Azilsartan medoxomil, the ARB component, blocks the receptors that angiotensin II normally binds to, thereby preventing its vasoconstrictive effects. This leads to the relaxation and widening of blood vessels, resulting in lowered blood pressure.

Additionally, chlorthalidone, the thiazide diuretic component, promotes diuresis (increased urine production) by inhibiting the reabsorption of sodium and water in the kidneys. This diuretic effect reduces the overall volume of blood in the body, further contributing to the lowering of blood pressure.

The combination of these two mechanisms of action makes Edarbyclor an effective medication for managing hypertension and improving overall cardiovascular health.

Warnings and Precautions 

While Edarbyclor can be effective in managing hypertension, it is important to be aware of the potential warnings and precautions associated with its use.

  • Cardiovascular Risk: Edarbyclor should not be taken by individuals who have a history of angioedema or hypersensitivity reactions to any component of the medication. It is also not recommended for use in patients with severe hepatic impairment or biliary obstructive disorders. Before starting Edarbyclor, inform your healthcare provider about any existing medical conditions, especially if you have heart problems or kidney disease. The medication may increase the risk of cardiovascular events such as heart attack or stroke.
  • Hypotension: Edarbyclor can cause low blood pressure, especially in individuals who are dehydrated or have salt depletion. It is important to stay adequately hydrated while taking this medication. If you experience symptoms such as dizziness, lightheadedness, or fainting, seek medical attention immediately.
  • Electrolyte Imbalance: Chlorthalidone, one of the active ingredients in Edarbyclor, is a diuretic that helps remove excess fluid from the body. However, it can also cause electrolyte imbalances, such as low potassium levels. Your healthcare provider may monitor your electrolyte levels periodically and may recommend dietary changes or additional supplements to maintain proper electrolyte balance.
  • Renal Impairment: Edarbyclor is not recommended for individuals with severe renal impairment or end-stage renal disease. It is important to inform your doctor if you have any kidney problems before starting this medication. Regular monitoring of renal function may be necessary during treatment.
  • Pregnancy and Breastfeeding: Edarbyclor should not be used during pregnancy, as it may cause harm to the fetus. It is essential to discuss contraceptive methods with your healthcare provider if you are of childbearing age and are taking Edarbyclor. Additionally, the medication can pass into breast milk and may harm a nursing infant. Consult your doctor before breastfeeding while using Edarbyclor.
  • Hyperkalemia: Edarbyclor may increase the levels of potassium in your blood. If you have conditions such as diabetes, chronic kidney disease, or are taking medications that can increase potassium levels, you may be at a higher risk of developing hyperkalemia. Regular monitoring of potassium levels is recommended during treatment with Edarbyclor.
  • Driving and Operating Machinery: Edarbyclor may cause dizziness or drowsiness in some individuals. If you experience these side effects, it is important to avoid activities that require alertness, such as driving or operating machinery, until you know how the medication affects you.
  • Allergic Reactions: Some individuals may experience allergic reactions to Edarbyclor. If you develop symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing, seek immediate medical attention.
  • Fluid and Electrolyte Imbalance: As Edarbyclor contains a diuretic, it is important to maintain proper fluid intake and be cautious about excessive fluid loss. This medication can cause dehydration or electrolyte imbalance, particularly in individuals who are elderly or have certain medical conditions.

Side Effects

While it is effective in lowering blood pressure, it’s important to be aware of the potential side effects that may arise from its use. In this article, we will explore the various side effects associated with Edarbyclor, including common, rare, and severe side effects. It is crucial to have a comprehensive understanding of these side effects to make informed decisions about your health.

Common Side Effects

  1. Dizziness: Some individuals may experience dizziness when starting Edarbyclor. This can be due to a sudden drop in blood pressure. It is important to take precautionary measures when engaging in activities that require alertness, such as driving or operating machinery.
  2. Fatigue: Feeling tired or experiencing a lack of energy is a common side effect of Edarbyclor. This can affect your daily activities and productivity. It is recommended to rest and allow your body to adjust to the medication.
  3. Headache: Headaches may occur as a result of the changes in blood pressure caused by Edarbyclor. If the headaches persist or become severe, it is advisable to consult your healthcare provider.

Rare Side Effects

  1. Allergic Reactions: In rare cases, individuals may experience allergic reactions to Edarbyclor. Symptoms may include hives, rash, itching, swelling, or difficulty breathing. If you notice any of these signs, seek immediate medical attention.
  2. Elevated Potassium Levels: Edarbyclor can increase the levels of potassium in your blood. This condition, known as hyperkalemia, may lead to various complications. Regular monitoring of potassium levels is essential to prevent any adverse effects.
  3. Gastrointestinal Issues: Some individuals may experience digestive problems such as nausea, vomiting, or diarrhea while taking Edarbyclor. If these symptoms persist or worsen, consult your doctor for further guidance.

Severe Side Effects

  1. Low Blood Pressure: Although Edarbyclor is primarily used to lower blood pressure, it can occasionally lead to excessively low blood pressure, known as hypotension. Symptoms may include lightheadedness, fainting, and confusion. If you experience these symptoms, seek immediate medical attention.
  2. Kidney Problems: Edarbyclor can potentially affect kidney function, especially in individuals with pre-existing kidney disease. If you notice changes in urination patterns, swelling, or difficulty breathing, contact your healthcare provider promptly.
  3. Liver Damage: In rare cases, Edarbyclor may cause liver damage. Symptoms of liver problems include yellowing of the skin or eyes (jaundice), dark urine, abdominal pain, and persistent fatigue. If you experience any of these symptoms, seek medical assistance without delay.

Drug Interactions 

As with any medication, it is essential to understand the potential drug interactions associated with Edarbyclor.

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

NSAIDs, such as Voltaren or Celebrex, are commonly used to relieve pain and reduce inflammation. However, when taken concurrently with Edarbyclor, they may reduce the effectiveness of the medication in lowering blood pressure. It is advisable to consult your healthcare provider before taking any NSAIDs while on Edarbyclor.

Potassium-Sparing Diuretics

Potassium-sparing diuretics, such as spironolactone or amiloride, are often prescribed to help the body get rid of excess water and salt while retaining potassium. When used with Edarbyclor, these diuretics can increase the risk of hyperkalemia (high potassium levels). Close monitoring of potassium levels is necessary if these medications are used together.


Lithium is commonly prescribed for the treatment of bipolar disorder. When taken with Edarbyclor, it can increase the concentration of lithium in the blood, leading to lithium toxicity. It is crucial to inform your healthcare provider if you are taking lithium or if you plan to start taking Edarbyclor.


Digoxin is a medication used to treat heart failure and certain heart rhythm problems. Concurrent use of Edarbyclor and digoxin may increase the risk of developing irregular heart rhythms. Regular monitoring of electrolyte levels and heart function is necessary if you are taking these medications together.

Diabetes Medications

Edarbyclor may affect blood glucose levels, especially in individuals with diabetes. If you are taking medications for diabetes, including insulin (such as Lantus or Humalog) or oral antidiabetic agents, it is essential to monitor your blood sugar levels closely while on Edarbyclor. Your healthcare provider may need to adjust your diabetes medication dosage accordingly.


Warfarin is an anticoagulant medication used to prevent blood clots. When taken with Edarbyclor, it can increase the anticoagulant effect of warfarin, leading to an increased risk of bleeding. Regular monitoring of blood clotting parameters is necessary if you are taking these medications together.


It’s important to note that the dosage may vary depending on your specific condition, so always follow the instructions provided by your healthcare professional.

Starting Dose

The recommended starting dose of Edarbyclor is 40/12.5 mg once daily. The first number represents the amount of azilsartan medoxomil in milligrams, and the second number represents the amount of chlorthalidone in milligrams.


If your blood pressure is not adequately controlled with the initial dose, your doctor may gradually increase the dosage. This process is known as titration and is done to achieve the desired therapeutic effect. The maximum recommended dose is 40/25 mg once daily.

Take with or without Food

Edarbyclor can be taken with or without food. It is essential to take the medication at the same time each day to maintain consistent blood levels and ensure its effectiveness.


Overdosing on Edarbyclor can have severe consequences and should be avoided at all costs. It’s crucial to follow the prescribed dosage and never exceed the recommended amount. If you accidentally take more than the prescribed dose, seek immediate medical attention or contact your local poison control center.

Symptoms of an overdose may include:

  • Severe dizziness
  • Fainting
  • Excessive thirst
  • Rapid or irregular heartbeat
  • Electrolyte imbalances

It is vital to remember that Edarbyclor should only be used under the supervision of a healthcare professional. If you suspect an overdose, do not hesitate to seek medical help.

Missed Dose

If you miss a dose of Edarbyclor, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

To ensure you don’t miss any doses, it may be helpful to set a daily reminder or use a pill organizer. Consistency in taking your medication is crucial for managing your blood pressure effectively.


When it comes to storing Edarbyclor, following the recommended guidelines is essential to preserve the medication’s potency and prevent any potential harm. Here, we will explore the best ways to store Edarbyclor to maintain its quality and efficacy.

Choose a Cool and Dry Location

To ensure the stability of Edarbyclor, it is important to store it in a cool and dry place. Avoid areas with excessive moisture, such as bathrooms, as humidity can degrade the medication. Instead, opt for a cabinet or drawer in a room with a stable temperature. Keeping the medication away from direct sunlight is also crucial.

Keep Away from Children and Pets

The safety of your loved ones is paramount, especially when it comes to medications. Edarbyclor should always be stored in a secure location, out of reach from children and pets. Consider using a lockable medicine cabinet or a high shelf to prevent accidental ingestion or tampering.

Maintain the Original Packaging

The original packaging of Edarbyclor is designed to protect the medication from light, moisture, and other environmental factors. It is recommended to keep the tablets or capsules in their original blister packs or containers. Avoid transferring them to other containers unless directed by your healthcare provider or pharmacist.

Check Expiry Dates

Regularly check the expiry dates of your Edarbyclor medication. Expired medication may not be as effective or could potentially cause harm. If you notice that your medication has expired, consult your pharmacist for proper disposal instructions and obtain a fresh supply.

Store According to Temperature Requirements

It is important to store Edarbyclor within the temperature range recommended by the manufacturer. Typically, the medication should be stored at room temperature, around 20-25 degrees Celsius (68-77 degrees Fahrenheit). Extreme temperatures can affect the stability and efficacy of the medication. Avoid storing it in areas prone to temperature fluctuations, such as near heaters, air conditioners, or refrigerators.

Keep Medication Out of the Bathroom

Although it may seem convenient, storing Edarbyclor in the bathroom is not ideal. The humidity and temperature changes in the bathroom can adversely affect the medication’s stability. Instead, choose a location outside the bathroom that meets the recommended storage conditions.

Do Not Freeze Edarbyclor

Freezing Edarbyclor is strictly prohibited. Extreme cold temperatures can alter the composition and effectiveness of the medication. If you accidentally freeze your Edarbyclor, contact your pharmacist for further guidance.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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