Candesartan is categorized as angiotensin II receptor blockers (ARBs). It is primarily used for preventing and managing hypertension and heart failure. The medication helps relax the blood vessels and lower blood pressure, thereby reducing the workload on your heart.

Candesartan works by preventing the action of angiotensin II, a hormone that releases aldosterone in the body. By reducing the release of aldosterone, candesartan helps to relax the blood vessels, improve blood flow, and lower blood pressure.

Improved blood flow and lowered blood pressure decrease the workload on your heart hence managing conditions like heart failure and hypertension.

Candesartan Precautions and Warnings

  • Pregnancy: Avoid using candesartan if you are pregnant or planning to get pregnant because it can cause injury or be fatal to the fetus during your second or third trimester.
  • Kidney Disease: Patients suffering from kidney problems should avoid taking candesartan because it can worsen their kidney condition.
  • Allergic Reactions: Before the administration of candesartan, inform your doctor if you are allergic to the medication or any of its ingredients because candesartan may contain some inactive components that can trigger allergic reactions.
  • Medical History: Inform your doctor about your medical background, especially if you have experienced an excessive loss of minerals or water, liver diseases, or if you have had hyperkalemia.
  • Driving and Operating Heavy Machinery: After taking the medication, avoid driving cars and operating heavy machinery because the drug causes dizziness.
  • Potassium Levels: Candesartan may increase the potassium levels in your blood when combined with potassium supplements or salt substitutes leading to hyperkalemia.

Side Effects of Candesartan

Candesartan is an effective medication in managing blood pressure but it can cause side effects in some patients. Knowing the potential side effects that can occur is important in ensuring the safe and effective use of candesartan.

Common Side Effects

  • Vomiting
  • Fever
  • Joint pain
  • Chills
  • Nausea
  • Headaches
  • Increased thirst
  • Back pain
  • Sore throat

Severe Side Effects

  • Nasal congestion
  • Low or high blood pressure
  • Allergic reactions
  • Kidney dysfunction
  • Increased potassium levels in your bloodstream
  • Confusion
  • Dark urine
  • Itching

Drug Interactions With Candesartan

Candesartan may interact with different types of medication and interfere with the effectiveness of the drug in preventing high blood pressure. Some drug interactions with candesartan include:

Drug Interaction
TrimethoprimUsing candesartan with trimethoprim concurrently increases potassium levels in the blood leading to hyperkalemia and causing symptoms such as muscle weakness and irregular heartbeat.
AliskirenThe interaction of Aliskiren with candesartan may increase the risk of kidney problems and decrease blood pressure.
Potassium supplementsCombining candesartan with potassium supplements may cause adverse effects such as fatigue, irregular heartbeats, muscle weakness, and cardiac arrest.
IbuprofenConcurrent use of ibuprofen and candesartan reduces the effectiveness of candesartan and may also impair kidney functions causing symptoms like increased blood pressure and gastrointestinal bleeding.
ACE inhibitorsUsing ACE inhibitors with candesartan increases hyperkalemia and kidney problems. Symptoms that may occur include cough, kidney dysfunction, and dizziness.
CorticosteroidsThe interaction between corticosteroids and candesartan may increase fluid retention and electrolyte imbalance. This can cause an increase in infections.

Strengths and Dosages of Candesartan

The dosage frequency of the medication can vary based on the patient’s factors like your age, the condition being treated, the severity of the condition, and how you respond to the initial dose.

You will start with a low dose of the medication. After a few weeks, your doctor will check your blood pressure and ask about any side effects. Blood tests will be conducted to evaluate kidney function and potassium levels in your bloodstream, then determine if there will be dosage adjustments needed.

Weight/Age Dosage  No. of Times per Day
Initial DosageMaintenance Dosage
1 to 6 years0.2 mg0.05 – 0.4 mg1 to 2 times per day
Children 6 – 17 years (less than 50kg)4 to 8 mg2 to 16 mg1 to 2 times per day
Adults greater than 50 kg8 to 16 mg4 to 32 mg1 to 2 times per day

Candesartan can be taken any time of the day but it is advisable to maintain a consistent schedule. It can be taken with or without food by swallowing the tablet as a whole using a cup of water. Do not chew or crush it.

Candesartan Alternatives

There are several alternative medications used in lowering blood pressure instead of candesartan. The medications operate through various mechanisms such as blocking the effects of hormones like angiotensin II. These alternatives have their unique characteristics and may be prescribed based on the patient’s needs and medical conditions. They include:

Candesartan FAQs

Should I take Candesartan in the morning or night?

Candesartan can be taken at any time throughout the day. It is advisable to establish a consistent daily schedule for administration at the same time every day for optimal effectiveness.

How fast does Candesartan work?

The medication begins to lower high blood pressure within approximately 2 hours after consuming. However, it requires up to 4 weeks of consistent use to achieve its full therapeutic effect.

What should you avoid when taking Candesartan?

Avoid taking potassium-containing salt substitutes like no salt or Morton salt substitute, potassium supplements, and high-potassium foods like noni juice.

What are the long-term side effects of Candesartan?

Prolonged usage of candesartan can occasionally lead to decreased kidney function. Your doctor should monitor your kidney function during your blood tests to check that they are working well.

How long does it take for Candesartan to leave your system

Candesartan has approximately a 9 to 12 hours half-life, meaning it typically takes about 1 to 3 days for the medication to be eliminated from your system after you stop taking it.

What painkillers can you take with Candesartan?

The best painkiller to take with candesartan is paracetamol because it does not have any effects on your kidneys.

What is the difference between Candesartan or Telmisartan?

Candesartan Telmisartan
Has minimal hepatic metabolismHas an extensive hepatic metabolism
Has a well-established efficacyHas robust clinical data for various indications
The duration of action is shorterThe duration of action is longer

How long does Candesartan stay in the system?

Candesartan stays in your system for about 24 hours after consumption.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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