Enbrel (Etanercept)
Enbrel (etanercept) is a prescription biologic medication used for certain autoimmune and inflammatory conditions. It is given as a subcutaneous (under-the-skin) injection and works by blocking TNF, a protein involved in inflammation.
We only dispense medications with a valid prescription from a licensed prescriber.
All prescriptions are reviewed and verified before dispensing. Orders may be delayed or declined if prescription details are missing, do not match the patient information on file, appear altered, or are expired. We may also refuse service if we believe an order is intended for resale or redistribution.
What You Receive
- Enbrel in sealed manufacturer packaging
- Personalized prescription instructions based on your prescriber’s directions
- Medication information leaflet provided by the manufacturer
- Itemized invoice detailing your order
- Rx Required
- Delivered Within 4-7 Days
- Medication From Canada
From $1,899.95 – $2,557.71
Shipping & Delivery
- Shipped from licensed pharmacy partners
- Tracking information is provided once your order ships
Delivery times may vary based on location and prescription verification.
This page is for general information only and is not medical advice. For medical questions, please speak with your prescriber. See Sources & Methodology for how this information is reviewed and referenced.
Enbrel Key Facts
What Enbrel is
Enbrel is a TNF blocker biologic (etanercept). It is available as an injection or for injection for subcutaneous use in several device/form options, depending on the prescribed dose and patient needs.
What it’s used for
Enbrel is used for rheumatoid arthritis, polyarticular juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis (including certain pediatric patients, depending on the condition and age).
How it works
Enbrel helps reduce inflammation by binding TNF (tumor necrosis factor) and blocking TNF activity. This can help reduce signs and symptoms and improve function in approved conditions.
Enbrel Safety Overview
Enbrel can affect your immune system and may increase the risk of serious infections.
Enbrel Warnings & Precautions
Enbrel also carries a boxed warning for serious infections and malignancies. Screening and monitoring are important before and during treatment.
Do not use Enbrel if:
- You have sepsis
- You have a serious active infection unless your prescriber tells you it is safe to start
- You have had a severe allergic reaction to etanercept or a product ingredient
Key warnings to know
- Serious infections can occur, including tuberculosis, fungal infections, bacterial infections, viral infections, and opportunistic infections
- Malignancies have been reported, including lymphoma and other cancers
- Heart failure can start or worsen
- Nervous system problems can occur, including demyelinating disorders
- Blood problems can occur
- Hepatitis b reactivation can occur in some patients with prior infection
- Serious allergic reactions can occur
- Lupus-like syndrome or autoimmune hepatitis can occur
- Live vaccines should generally be avoided during treatment
Side Effects and When to Get Help
Enbrel can cause common side effects and also serious reactions that need urgent medical attention. The most commonly reported side effects include infections and injection-site reactions.
Possible side effects may include
- Injection-site reactions such as redness, itching, pain, swelling, bruising, or bleeding
- Upper respiratory infections, including sinus infections
- Mild irritation or soreness around the injection area
- Common infection symptoms such as fever, cough, or feeling unwell
Get urgent help right away for
- Signs of a serious allergic reaction such as trouble breathing, facial swelling, or severe rash
- Signs of a serious infection such as high fever, severe weakness, or rapidly worsening illness
- Signs of heart failure such as shortness of breath or swelling in the legs or feet
- Unusual bleeding or bruising, or very pale skin
- Numbness, tingling, vision changes, or weakness
- Yellowing of the skin or eyes, or severe right-sided abdominal pain
Interactions
Enbrel can interact with certain vaccines and immune-modulating medicines. Your prescriber should review all prescription medicines, biologics, and vaccines before you start or continue treatment.
Interactions you should discuss with your prescriber include
- Live vaccines
- Anakinra
- Abatacept
- Cyclophosphamide
- Sulfasalazine
- Methotrexate, steroids, nsaids, and other immune-affecting medicines
Enbrel Drug Facts
| Category | Details |
|---|---|
| Brand Name | Enbrel |
| Drug Class | TNF blocker biologic |
| Indication | RA, pJIA, PsA, AS, plaque psoriasis |
| Dosage Forms | SC injection; solution and powder for reconstitution |
| Strengths | 25 mg/0.5 mL, 50 mg/mL, 25 mg vial (lyophilized) |
| Administration Timing | Usually weekly; adult plaque psoriasis may start twice weekly (then weekly) |
| Boxed Warning | Serious infections, malignancies; do not use in sepsis |
| Storage | Refrigerate 36°F to 46°F in original carton; do not freeze or shake |
| Missed Dose | Inject when remembered, then resume regular schedule; ask prescriber/pharmacist if unsure |
| Alternatives | Humira (adalimumab), Simponi (golimumab), Cimzia (certolizumab), Remicade/Inflectra (infliximab) |
Helpful Information
How To Buy Enbrel Online
1
Select Your Prescribed Enbrel Dosage & Strength
Choose the strength and quantity that matches your prescription, then add it to your cart. Orders are limited to a 90-day supply per fill.
2
Complete Checkout
Ensure your shipping and contact information is correct so your order can be processed without delays.
3
Submit Your Enbrel Prescription
Upload your prescription at checkout. If you need a transfer, provide your prescriber or current pharmacy details and we will request it on your behalf.
Prescription & Dispensing Standards
- Prescription required for all orders and reviewed for pharmacy and regulatory compliance
- Dispensed by licensed pharmacy partners
- Orders are held if information is missing, unclear, or does not match.
- No substitutions without prescriber approval, and no controlled substances.
Our Guarantee
At MyRx Outlet, we are committed to delivering safe, high-quality medications that you can trust. We adhere to strict regulations in every country we operate in, ensuring that your order is handled by a licensed Canadian pharmacy or a trusted partner overseas. Each medication has been legally approved by Health Canada or other respected authorities. To purchase Enbrel at a discounted rate, call 1-888-551-2467.
FAQs
What is Enbrel used for?
Enbrel is used for certain inflammatory and autoimmune conditions, including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, and plaque psoriasis in eligible patients.
How often is Enbrel taken?
Dosing depends on the condition, age, weight, and product form. Many adult uses are weekly, while some plaque psoriasis regimens may start with a twice-weekly phase before weekly maintenance.
What checks are usually done before starting Enbrel?
Patients are typically evaluated for infection risk before starting treatment, including tuberculosis screening. Vaccination status should also be reviewed before therapy begins.
What should I do if I miss a dose of Enbrel?
Inject the missed dose when you remember, then continue your regular schedule. If you are unsure when the next dose should be, contact your prescriber.
Does Enbrel need to be refrigerated?
Yes. Enbrel is usually stored in the refrigerator in the original carton. Some product forms may allow limited room-temperature storage, but follow the exact instructions for your prescribed version.
Ordering & Prescription FAQs
Do I need a prescription?
Yes, a prescription is required. Refills depend on what your prescriber authorizes.
How do I submit my prescription?
You can upload it through our Upload Prescription page, email it to info@myrxoutlet.com, or fax it to 1-888-230-1245. If you need a prescription transfer, just let us know at checkout and include your pharmacy or prescriber contact details.
When is my payment processed?
Your payment is processed only after your prescription and order have been reviewed and approved by our licensed pharmacy team. Once everything is confirmed, we’ll process payment and prepare your order for shipping.
What happens if my prescription can’t be verified?
Your order may be placed on hold or declined if prescription details are missing, don’t match, are expired, or can’t be confirmed.
Sources
FDA Prescribing Information / Medication Guide, ENBREL (etanercept)
https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/103795s5591lbl.pdf
DailyMed, ENBREL (etanercept) injection / for injection
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a002b40c-097d-47a5-957f-7a7b1807af7f