Advicor (Niacin, Lovastatin)
Advicor is a combination cholesterol medication that contained extended-release niacin and lovastatin. FDA approval was withdrawn in April 2016 after the manufacturer requested withdrawal, and it is no longer marketed as an approved product in the U.S.
We only dispense medications with a valid prescription from a licensed prescriber.
All prescriptions are reviewed and verified before dispensing. Orders may be delayed or declined if prescription details are missing, do not match the patient information on file, appear altered, or are expired. We may also refuse service if we believe an order is intended for resale or redistribution.
What You Receive
- Advicor (or approved equivalent) in sealed manufacturer packaging
- Personalized prescription instructions based on your prescriber’s directions
- Medication information leaflet provided by the manufacturer
- Itemized invoice detailing your order
- Rx Required
Discontinued
Shipping & Delivery
- Shipped from licensed pharmacy partners
- Tracking information is provided once your order ships
Delivery times may vary based on location and prescription verification.
This page is for general information only and is not medical advice. For medical questions, please speak with your prescriber. See Sources & Methodology for how this information is reviewed and referenced.
Advicor Key Facts
What Advicor is
A combination tablet that contained niacin extended-release plus lovastatin (a statin).
What it’s used for
A combination tablet that contained niacin extended-release plus lovastatin (a statin).
How it works
Lovastatin lowers LDL cholesterol by reducing cholesterol production in the liver.
Niacin ER can lower triglycerides and raise HDL, but it also has important safety limitations.
Advicor Safety Overview
Advicor carried clinically important risks, including liver injury and muscle injury (myopathy/rhabdomyolysis), especially when combined with certain interacting drugs. It also had statin-class pregnancy restrictions.
Advicor Warnings & Precautions
Any unexplained muscle pain, weakness, dark urine, or severe fatigue requires prompt medical attention.
Do not use Advicor if:
- Any unexplained muscle pain, weakness, dark urine, or severe fatigue required prompt medical review
- Pregnancy or breastfeeding (statin component)
- Use with certain strong interacting drugs listed in labeling (see Interactions)
Key warnings to know
- Liver toxicity risk, including serious reactions in rare cases
- Muscle injury risk increases with interacting medicines and certain medical conditions
- Niacin can worsen blood sugar control and can raise uric acid, which may trigger gout
- Not recommended during pregnancy; statins were contraindicated in pregnancy in labeling
Side Effects and When to Get Help
Niacin commonly causes flushing and warmth, especially when starting or increasing doses. More serious risks include liver injury and severe muscle injury. Seek urgent care for severe weakness, dark urine, yellowing skin/eyes, severe abdominal pain, or chest pain.
Common effects reported with niacin/statin therapy may include:
- Flushing, itching, warmth, headache
- Upset stomach
Get urgent help right away for
- Unexplained muscle pain, tenderness, or weakness
- Dark urine, fever, or severe fatigue along with muscle symptoms
- Yellowing of the skin or eyes, severe upper abdominal pain, or persistent nausea
- Facial swelling, trouble breathing, widespread rash
Interactions
The highest-risk interactions were those that raised lovastatin exposure, which increased the chance of serious muscle injury. Before starting any statin-containing regimen, a prescriber must review antibiotics, antifungals, HIV medicines, transplant medicines, and other lipid-lowering drugs.
Interactions to review with your prescriber may include:
- Strong CYP3A4 inhibitors that can significantly increase lovastatin levels
- Cyclosporine and danazol due to increased muscle injury risk
- Gemfibrozil and certain other lipid therapies due to additive muscle risk
- Heavy alcohol use due to increased flushing and added liver risk
Advicor Drug Facts
| Category | Details |
|---|---|
| Brand Name | Advicor |
| Drug Class | Primary hypercholesterolemia and mixed dyslipidemia as an adjunct to diet in appropriate patients |
| Dosage Form | Extended-release tablet |
| Strengths | Multiple fixed-dose combinations were marketed (niacin ER with lovastatin). Strength options varied by market and time period |
| Key Safety Alerts | Liver injury risk and myopathy risk, increased with interacting drugs |
| Who should not use it | Active liver disease, hypersensitivity, and other labeled contraindications. Pregnancy and breastfeeding restrictions applied under historical labeling |
| Administration Timing | Historically used once daily at bedtime with gradual dose escalation to improve tolerability, per labeling strategy |
| Monitoring | Lipid panel, liver enzymes, and evaluation of muscle symptoms. Consider glucose and uric acid monitoring in at-risk patients |
| Indication | Primary hypercholesterolemia and mixed dyslipidemia as an adjunct to diet in appropriate patients |
| Alternatives | Lovastatin, atorvastatin (Lipitor), rosuvastatin (Crestor), simvastatin, pravastatin, ezetimibe, PCSK9 inhibitors (when appropriate) |
Helpful Information
How To Buy Advicor Online
1
Select Your Prescribed Advicor Dosage & Strength
Choose the strength and quantity that matches your prescription, then add it to your cart. Orders are limited to a 90-day supply per fill.
2
Complete Checkout
Ensure your shipping and contact information is correct so your order can be processed without delays.
3
Submit Your Advicor Prescription
Upload your prescription at checkout. If you need a transfer, provide your prescriber or current pharmacy details and we will request it on your behalf.
Prescription & Dispensing Standards
- Prescription required for all orders and reviewed for pharmacy and regulatory compliance
- Dispensed by licensed pharmacy partners
- Orders are held if information is missing, unclear, or does not match.
- No substitutions without prescriber approval, and no controlled substances.
Our Guarantee
At MyRx Outlet, we are committed to delivering safe, high-quality medications that you can trust. We adhere to strict regulations in every country we operate in, ensuring that your order is handled by a licensed Canadian pharmacy or a trusted partner overseas. Each medication has been legally approved by Health Canada or other respected authorities. To purchase Advicor at a discounted rate, call 1-888-551-2467.
FAQs
Is Advicor still FDA-approved in the U.S.?
No. FDA approval was withdrawn effective April 18, 2016.
What was Advicor used for?
It was used as an adjunct to diet to treat certain cholesterol disorders in appropriate patients.
What side effect was most common?
Flushing and warmth were common due to the niacin component, especially early in therapy.
What are the most serious safety risks?
Serious risks included liver injury and severe muscle injury, especially with certain drug interactions.
Which interactions mattered most?
Medications that raise lovastatin levels and increase muscle injury risk were especially important to screen for.
Can niacin affect diabetes or gout?
Yes. Niacin can worsen blood sugar control and can raise uric acid.
Ordering & Prescription FAQs
Do I need a prescription?
Yes. But, Advicor is discontinued and we will not ship this medication to the United States.
How do I submit my prescription?
You can upload it through our Upload Prescription page, email it to info@myrxoutlet.com, or fax it to 1-888-230-1245. If you need a prescription transfer, just let us know at checkout and include your pharmacy or prescriber contact details.
When is my payment processed?
Your payment is processed only after your prescription and order have been reviewed and approved by our licensed pharmacy team. Once everything is confirmed, we’ll process payment and prepare your order for shipping.
What happens if my prescription can’t be verified?
Your order may be placed on hold or declined if prescription details are missing, don’t match, are expired, or can’t be confirmed.
Sources
FDA label (historical), Advicor (niacin extended-release/lovastatin)
https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021249s029lbl.pdf
DailyMed label, Advicor (niacin and lovastatin) extended-release tablet
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dbdee4c0-86fa-4857-b536-79bf9ebb911a
FDA notice in Federal Register, withdrawal of approval for Advicor and Simcor
https://www.federalregister.gov/documents/2016/04/18/2016-08894/abbvie-inc-withdrawal-of-approval-of-new-drug-applications-for-advicor-and-simcor
GovInfo PDF of the Federal Register notice (2016-08894)
https://www.govinfo.gov/content/pkg/FR-2016-04-18/pdf/2016-08894.pdf