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Crestor (Rosuvastatin Calcium)
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Crestor is a type of medication used to reduce high levels of bad cholesterol (low-density lipoprotein/LDL), and triglycerides in the blood hence preventing cardiovascular conditions. It contains an active ingredient called rosuvastatin.
This medication falls under a group of drugs called statin, which functions by reducing the liver’s production of LDL cholesterol in the bloodstream. The drug is typically taken alongside diet and exercise.
Adult males aged 50 or more and females of 60 years and above usually take Crestor to reduce the risk of heart complications, including stroke, and heart attack.
Crestor works in two ways:
- It inhibits the action of HMG-CoA reductase which reduces the liver’s ability to produce cholesterol. This decreases the overall level of cholesterol in the bloodstream.
- Crestor also increases the breakdown of LDL cholesterol in the liver commonly referred to as ‘’bad ’’ cholesterol. As statin lowers LDL cholesterol levels in the body it also increases HDL cholesterol levels, known as ‘’good ’’ cholesterol. HDL cholesterol aids in removing LDL cholesterol from the bloodstream, transporting it back to the liver for excretion, thereby reducing the risk of plaque formation in the arteries.
Crestor Precautions and Warnings
- Rhabdomyolysis and Myopathy: Using Crestor can potentially cause you to develop Rhabdomyolysis and Myopathy. Inform your doctor if you experience any signs and symptoms of muscle pain, muscle atrophy, and fatigue.
- Hepatic Dysfunction: Crestor has the potential to cause hepatic dysfunction. Patients taking alcohol or have a history of liver disease may face a higher risk of hepatic dysfunction.
- Hematuria and Proteinuria: Patients taking higher doses of Crestor (40mg) are at risk of experiencing Hematuria and Proteinuria. Consider reducing your dosage if you exhibit persistent unexplained proteinuria or hematuria.
- Increased HbA1c and Fasting Serum Glucose Level: Taking Crestor may lead to increased HbA1c and fasting serum glucose levels. You should focus on lifestyle improvements such as regular exercise and adopting a nutritious diet to prevent it.
- Asian Heritage: People of Asian descent should start taking Crestor at lower dosages as they are at an increased risk of experiencing severe side effects like statin-associated muscle symptoms.
- Older People: If you are above the age of 65, you should use an alternative medication to Crestor because you may be at a high risk of developing myopathy and rhabdomyolysis.
Side Effects of Crestor
Crestor aims to lower cholesterol levels and decrease the risk of cardiovascular conditions. However, it may induce side effects in certain patients. Recognizing the potential side effects is crucial for making informed decisions and managing your health effectively
Common Side Effects
- Constipation
- Nausea
- Stomach pain
- Loss of appetite
- Vomiting
- Fever
- Dry or sore throat
- Headache
- Dizziness
Severe Side Effects
- Blood and protein in your urine
- Joint pain
- Unexplained weight loss
- Chest tightness
- Clay-coloured stool
- Muscle pain and aches
- Trouble sleeping
Drug Interactions With Crestor
Understanding potential interactions with other drugs is essential when taking Crestor to prevent possible adverse side effects. The interaction can also affect the efficacy of Crestor in managing your condition. Gaining insights into Crestor helps optimize treatment outcomes while minimizing risks.
| Drug | Interaction |
| Ni Cain (Nicotine Acid) | The interaction between Ni Cain and Crestor may increase the risk of muscle-related side effects such as rhabdomyolysis, and myopathy, leading to liver enzyme abnormalities. |
| Cyclosporine | Combining cyclosporine and Crestor can increase the blood levels of Crestor and intensify side effects such as severe muscle pain, weakness, and potentially life-threatening complications. |
| Diltiazem | Using diltiazem concurrently with Crestor raises the blood concentration of Crestor. This can enhance the risk of muscle-related adverse effects such as myopathy. |
| Erythromycin | Concurrent use of erythromycin and Crestor causes gastrointestinal issues, including side effects such as constipation, nausea, and vomiting. |
| Niacin | Medication such as Niacin (found in Advicor) when used concurrently with Crestor may affect blood sugar levels, if you are suffering from diabetes, potentially leading to hypoglycemia. |
| Warfarin | Taking Warfarin while using Crestor increases the risk of bleeding, leading to side effects such as nausea, headaches, and dizziness. |
Strengths and Dosages of Crestor
The strengths and dosages of Crestor depend on factors like your age, any other medical conditions you may have, the medications you are currently taking, whether you are of Asian descent, and how you will respond to the drug.
Your initial treatment will be moderate, and your doctor will adjust it gradually to find the optimal dosage. The objective is to prescribe the lowest effective amount of Crestor, ensuring it achieves the desired effect while minimizing potential side effects.
| Age | Dosing | No. of Times a Day |
| Children 8 to 9 years of age
| 5 mg – 10 mg | Once per day |
| Children 10 – 17 years of age
| 5 mg -20 mg | Once per day |
| Adults 18 years and above
| 5 mg – 40 mg | Once per day |
Crestor is taken orally as a single dose at any time of the day, with or without food. Swallow the tablet whole without chewing or crushing it.
Cost of Crestor in America
The price of a supply of 90 Crestor oral tablets each containing 5 mg is $883. However, the price can vary depending on the pharmacy you purchase the drug. This cost applies to customers paying out of pocket and may not be applicable if you have medical insurance coverage.
Why is Crestor so Expensive?
The high cost of Crestor can be attributed to a combination of factors. Which include:
- The production of the drug needs a complex manufacturing process and quality standard, which helps guarantee the medication’s efficacy, safety, and consistency. The high manufacturing costs contribute to the overall expense of producing Crestor.
- The process of developing a new medicine entails conducting extensive research, clinical trials, and obtaining regulatory approvals, which needs financial investments. The research and development costs are factored into the pricing of the medication.
- Crestor is a brand-name medication. Brand-name medications are often more expensive than their generic version due to factors like brand recognition, marketing expenses, and perceived quality.
Crestor Alternatives
Alternative medications to Crestor are available that can effectively manage cholesterol levels while addressing patients’ needs and preferences. Patients may opt for alternatives due to personal preference for instance if they find Crestor too expensive or for medical considerations, if they cannot tolerate Crestor well. Some alternatives that patients can consider include:
- Zetia
- Bembedoic acid
- Lipitor
- Welchol
- Inclisiran
- Zocor
- Altoprev
- Leqvio
- Simvastatin
- Praluent
- Lescol XL
- Pravachol
- Niaspan
- Evolocumab
Crestor FAQs
What is Crestor used for
Crestor is used to lower “bad” cholesterol, prevent cardiovascular disease, treat hyperlipidemia, and manage familial hypercholesterolemia.
What foods should be avoided when taking Crestor?
Avoid consuming foods that are high in fats or cholesterol because it can decrease the effectiveness of Crestor. Also, avoid drinking alcohol as it can elevate triglyceride levels and increase the risk of liver damage.
How long does Crestor stay in your system?
The half-life of Crestor is approximately 14 hours, therefore, it takes almost 14 hours for the Crestor blood levels to decrease by half.
Is there a generic for Crestor?
Yes. The generic version of Crestor is available called rosuvastatin.
What is the difference between Crestor and Lipitor (make a comparison table)
| Crestor | Lipitor |
| More potent at lowering LDL at a lower dose. | Effective at lowering LDL at higher doses. |
| Slightly greater increase in HDL | A moderate increase in HDL |
| Fewer interactions due to metabolism | More potential interactions due to CYP3A4 |
Should you take Crestor near bedtime?
While taking Crestor before bedtime is recommended because cholesterol is usually high at night, patients can still take Crestor at any time of the day. You only need to select a time that is convenient for you and take the medication at the same time each day.
How long does it take for Crestor to work?
It can take approximately 2-4 weeks for Crestor to reduce LDL cholesterol in your body.
How long does it take for Crestor to get out of your system?
The half-life of Crestor is 14 hours, meaning it will take 3 days for Crestor to clear from your system.
How much will Crestor lower my cholesterol?
Crestor has been demonstrated to reduce LDL cholesterol by up to 55% at a 20-mg dose, compared to a 7% reduction with a placebo.
Does Crestor cause muscle pain?
Yes. Muscle pain is a potential side effect of the medication, although not every patient experiences it. Patients may experience muscle pain or weakness.
Our Guarantee For Buying Crestor From A Canadian Pharmacy Partner
At MyRx Outlet, we are committed to delivering safe, high-quality medications that you can trust. We adhere to strict regulations in every country we operate in, ensuring that your order is handled by a licensed Canadian pharmacy or a trusted partner overseas. Each medication has been legally approved by Health Canada or other respected authorities. To purchase Crestor at a discounted rate, call 1-888-551-2467.
IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.
