Rupall is regarded as a second-generation antihistamine with the active ingredient rupatadine. The drug helps to cure inflammation of the nasal membrane. Still, some physicians may use it in the treatment of chronic urticaria.

It relieves sneezing, itching, watery eyes, and runny nose. Rupall provides effective relief, but over-the-counter options like cetirizine (Zyrtec), loratadine (Claritin), fexofenadine (Allegra), and diphenhydramine (Benadryl, Unisom) may provide similar relief at different prices. A healthcare expert can help patients choose the best solution based on their needs and budget.

How Does Rupall Work?

  • Blocks Histamine Receptors: Being a second-generation antihistamine, Rupall works by blocking the histaminic receptors. As a result, it obstructs the operation of your body’s organic compound histamine, which is released when exposed to allergens. Histamine causes most symptoms of allergic reactions.
  • Obstructs PAF Receptors: Additionally, rupatadine is known to impede platelets-activating factor receptors and exhibit anti-inflammatory attributes. Their combined effort prevents inflammation in the nasal membrane brought about by allergic reactions.

Rupall Precautions and Warnings

  • Alcohol Consumption: Avoid taking alcohol while on rupatadine as it may potentiate the sedative effects of alcohol and cause drowsiness.
  • Avoid Driving: Don’t drive or operate on heavy machinery while taking this medication as it causes dizziness.
  • Nursing Women: Even though rupatadine is excreted in animal milk, it’s not clear if the same can happen with breast milk. So consult your doctor before using it.
  • Cardiac Electrophysiology: Rupall can cause electrolyte imbalance, so care should be exercised when administering the medication to individuals at increased risk of experiencing cardiac electrophysiology.
  • Impaired Kidney Functions: Patients having renal insufficiency are not recommended to use rupatadine as it affects kidney function unless advised otherwise by a doctor.
  • Pregnant Women: As a precautionary measure it is best to avoid the use of Rupall during pregnancy unless advised by your doctor.
  • Children: Do not administer to children under 12 years of age as its safety and effectiveness are not established yet.

Rupall Side Effects

Individuals who use rupatadine as a solution to treat their allergies experience unintended responses. Some of these effects are mild and part of adjusting to the drug while others are severe and require prompt medical assistance.

Common Side Effects

Most people taking Rupall may experience these side effects. These side effects are usually mild and disappear on their own.

  • Headache
  • Tiredness
  • Nausea
  • Dizziness
  • Dry mouth

Severe Side Effects

Be cautious of the rare but adverse reactions of Rupall. Call 911 if you experience any of these side effects:

  • Fainting
  • Difficulty breathing
  • Chest tightness
  • Abnormal heart rhythm
  • Signs of muscle damage (like unexplained muscle pain, weak muscles, or discolored urine)
  • Abdominal pain

Rupall Drug Interactions

Individual drug-drug interaction occurred with rupatadine. Particular care should be exercised when administering the Rupall to patients who are using other medications. Some common interactions include:

DrugType of Interaction
Antipsychotics such as chlorpromazine, clozapine, risperidoneWorsen side effects of either drug
Certain antifungals like itraconazole (Sporanox), ketoconazoleIncreases concentration of Rupall worsening side effects
Agomelatine and CevimelineMay decrease the metabolism of rupatadine
Medications like cetirizine, chlorcyclizine, gatifloxacin, moxifloxacin, and pimozideCan increase risk of abnormal heart rhythm ( Specifically QT prolongation)
Sedative-hypnoticsWill heighten sedative effects and worsen drowsiness

Rupall Strengths and Dosages

The following table lists the strengths and dosages of Rupall, an antihistamine that is used to treat allergy symptoms:

Dosage FormStrengthRecommended Dosage
Tablet10 mgAdults and children over 12 years old: 1 tablet once daily with or without food
Children 6 to 12 years old: Half a tablet (5 mg) once daily with or without food
Oral Solution1 mg/mLAdults and children over 12 years old: 10 mL (10 mg) once daily with or without food
Children 6 to 12 years old: 5 mL (5 mg) once daily with or without food


Dosages depend on medical circumstances and doctor recommendations. Consult a doctor before starting or modifying a drug.

Rupall Alternatives

  • Antihistamine Cetirizine: Antihistamine Cetirizine (Zyrtec) is widely available in the US. The generic version of Zyrtec is often cheaper.
  • Antihistamine Loratadine: Over-the-counter antihistamine Loratadine (Claritin) is another popular choice. It’s available in generic and brand-name forms and costs similarly to cetirizine.
  • Fexofenadine: Over-the-counter Fexofenadine (Allegra) costs about the same as cetirizine and loratadine. Purchasing generic Allegra rather than the brand name may save money.
  • Diphenhydramine (Benadryl, Unisom): This older antihistamine is cheaper than newer ones. Generic diphenhydramine is widely available and affordable.

Alternatives for allergy relief at different price points allow patients to choose based on their preferences and budget. A doctor should assess your medical history and needs to determine the best course of action.


How often should I take Rupall?

Drug and individual dosage directions vary. Rupall, cetirizine, loratadine, and fexofenadine are used once daily, whereas diphenhydramine can be taken every 4–6 hours as needed. Following your doctor’s or medication’s directions is vital.

Do Rupall and its substitutes have side effects?

Antihistamines can cause drowsiness, dry mouth, headache, and gastrointestinal discomfort. Side effects vary by medicine and person. Discuss concerns with a doctor before starting a new medication.

Can I use Rupall with other drugs?

Before taking any new drug, especially if you take others, visit a doctor. Some drugs interact with Rupall reducing efficacy or causing side effects.

Are there special considerations for children, pregnant women, and aged people?

These populations may need special antihistamine doses or precautions. To ensure safety and efficacy, consult a doctor before providing medication to children, pregnant or breastfeeding women, or the elderly.

How much does Rupall cost in the United States?

In 2024, Rupall tablets cost $1.33–$2 in the US. This price range may vary by pharmacy or location. A 30-tablet supply costs $39.90–$60.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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