Nidagel is an antibiotic that treats vaginal bacterial infections such as vaginosis. Its active ingredient is metronidazole, a nitroimidazole antibiotic. Vaginal gel Nidagel targets infection directly in the vagina.

It eliminates infections and manages symptoms, including abnormal vaginal discharge and odor, by preventing bacteria growth and replication. Using the prescribed Nidagel dosage correctly and finishing the course will eliminate the infection and reduce the chance of recurrence.

How Does Nidagel Work?

Nidagel (metronidazole vaginal gel) kills bacteria that cause bacterial vaginosis. It works by stopping bacterial development. The drug targets and disrupts bacterial DNA, preventing it from replication and survival.

Direct administration of this topical gel maximizes vaginal infection treatment while minimizing systemic side effects. Follow your doctor’s dose and treatment plan to get the best results.

Warnings and Precautions of Nidagel

When choosing a drug, weigh its risks and warnings against benefits. This should always be a decision between you and your doctor. Some Nidagel warnings and precautions you need to consider before deciding if it is the right antibiotic for you include:

  • Allergies: Tell your doctor if you’ve had any unexpected or adverse reactions to this or other related drugs.
  • Pediatric: Nidagel’s effects in children have not been studied, so there’s little and insufficient research on the safety and efficacy of Nidagel on children under 12 years old.
  • Geriatric: Previous investigations have not found geriatric-specific issues that would limit the use of Nidagel in older people. However, dosage adjustment is required for persons of age 65 and above.
  • Breastfeeding: No adequate studies in women have determined risks to a baby when using this drug while breastfeeding. Consult your doctor on the pros and cons before taking this drug during breastfeeding.

Side Effects of Nidagel

The antibiotic metronidazole, sold as Nidagel, treats bacterial and parasite diseases. Like many drugs, metronidazole has adverse effects, both mild and severe. If you experience any of these severe side effects or other unexpected symptoms while using Nidagel or metronidazole, get medical attention immediately. They can advise and alter treatment accordingly.

Common Side Effects

  • Gastrointestinal effects such as nausea, vomiting, appetite loss, gastric cramps and diarrhea
  • Severe Headache
  • Frequent Dizziness
  • Drowsiness
  • Oral metallic taste
  • Itching or discharge (for gels)

Rare Yet Serious Effects

  • Allergic reactions with allergic symptoms such as rash, itching, swelling, severe dizziness
  • Problems breathing may be experienced
  • Hands or feet numb or tingling
  • Urination pain or difficulty
  • White mouth or lip sores
  • Dark urine
  • Frequent nausea or vomiting
  • Serious abdominal discomfort
  • Unusual fatigue or weakness
  • Antibiotic-related diarrhea: In rare cases, you may experience a severe kind of diarrhea associated with a condition known as pseudomembranous inflammation.

Drug Interactions With Nidagel

Nidagel (metronidazole vaginal gel) may interact with other drugs, causing side effects or lowering their efficacy. Before administering Nidagel treatment, please get specific guidance from your doctor or pharmacist. They will assess you and advise based on your medical history and specific illness. Before starting Nidagel, tell your doctor about all your medications, vitamins, and herbal products. Common medication interactions include:

  • Warfarin and Other Blood Thinners: Nidagel may increase bleeding risk when taken with Warfarin. You must closely monitor blood coagulation characteristics in such circumstances.
  • Disulfiram: When used together, Nidagel and disulfiram, an alcohol-dependent medicine, can produce severe nausea, vomiting, and headaches by inhibiting the breakdown of acetaldehyde.
  • Lithium: Nidagel may raise blood lithium levels, causing toxicity. Using these drugs together may require lithium monitoring and dosage modifications.
  • Alcohol: Avoid drinking alcohol while using Nidagel and for at least 48 hours after therapy to avoid flushing, rapid heartbeat, nausea, and vomiting.
  • Phenytoin: Nidagel may enhance the risk of adverse effects when administered with phenytoin or phenobarbital. These situations may require close monitoring and medication changes.

Nidagel Strengths and Dosages

The strengths and dosage will depend on the bacterial and fungal infection you suffer from and the severity of the disease. Age is also an important factor when determining the dosage of Nidagel.

Form Age Dosage Frequency
Nidagel Cream Adults One applicatorful containing 500 mg 1 or 2 times a day for 20 or 10 days
Nidagel Gel Adults and children above 12 years One applicatorful 5 g Once per day for 5 days
Tablets Adults One 500 mg tablet Once per day for 10 or 20 days

Nidagel is generally prescribed to adults and children above 12 years old. Since there’s not enough research to ascertain the efficacy and safe use of Nidagel for children below 12 years, you need to talk to your doctor before prescribing the medication.

For adults and children above 12 years, the medication is applied once a day in the vagina. Ensure you use a sanitary towel to prevent staining your underwear when the drug leaks.

Nidagel may irritate during the first few minutes of application. If the feeling continues or gets intense, please seek medical advice immediately.

You may also use the drug while on your menstruation period.

Nidagel Alternatives


Patients can use Tinidazole as an alternative to Metronidazole. Tinidazole is an antibiotic that belongs to the same group as metronidazole. It’s used to cure a wide variety of infections, including bacterial vaginosis, trichomoniasis, and giardiasis. While you can take the medication without food, doctors advise patients to take it with food to prevent stomach aches.


Solosec can also be used in place of metronidazole. This medication is used to treat sexually transmitted infections (STIs) and is available as a single dose for a complete course.

Questions And Answers of Nidagel

How does Nigel work?

Nidagel is a medication used to treat bacterial and parasitic infections. It prevents the growth and replication of microorganisms.

Is there any food or drink I need to avoid?

Avoid consumption of alcohol while taking Nidagel. Combining Nidagel with alcohol can lead to unpleasant side effects such as headache and vomiting.

Is it safe to use Nidagel during pregnancy?

The medication can be used by pregnant women suffering from bacterial and fungal infections. However, it is advisable not to use Nidagel during the first trimester of pregnancy.

How do I store Nigel?

Keep the medicine at room temperature, away from children and pets. If you have any unused or expired drugs, dispose of them properly. Please do not throw it or flush it down the toilet.

Is it safe to drive or operate heavy machinery while using Nigel?

Avoid driving or operating heavy machinery when taking the medication, as it may cause symptoms like drowsiness and dizziness.

What do I need to know before taking the drug?

Before taking the medication, you should be aware of any allergic reactions related to it or any other food that may interact with it and immediately inform your healthcare provider about them.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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