Colchicine is an anti-gout agent and prescription drug that is designed to avert or treat gout episodes. Gout becomes a problem when the body builds up excess levels of uric acid. That uric acid can then cause the formation of painful crystals in the joints or kidneys.

Colchicine is also used to tackle cardiovascular problems and treat a rare medical illness known as familial Mediterranean fever (FMF).

This medication works by reducing uric acid crystal buildup in the joints and relieving swelling. In cases of cardiovascular problems and treating FMF, Colchicine works by stopping the buildup of the amyloid A protein which is quite common in FMF cases.

This prescription drug does not work as a pain reliever for other ailments.

Precautions and Warnings with Colchicine

Before taking Colchicine, you should let your doctor know about any allergies you have and your health history. This prescription drug may not be safe for people with liver complications or kidney problems.

Colchicine may negatively impact your ability to take in various nutrients, like vitamin B12, and different foods. Alcohol consumption may adversely impact the effectiveness of colchicine.

You should inform your doctor about any herbs, supplements, nutritional products, vitamins, or medications that you’re taking. If you are pregnant, planning to get pregnant, breastfeeding, or planning to breastfeed, you should alert your doctor before you start taking Colchicine.

Consuming grapefruit or grapefruit juice can lead to negative side effects while taking Colchicine.

Colchicine Side Effects

Colchicine affects your blood supply, enzymes, and protein levels and may lead to a series of various side effects.

Mild Side Effects

If you begin to have mild side effects after starting Colchicine, they may go away with time as your body gets used to the medicine. If the following side effects persist, be sure to inform your doctor:

  • Cramping
  • Nausea
  • Abdominal pain
  • Vomiting
  • Diarrhea

Severe Side Effects

If you begin to have severe side effects after you begin Colchicine, you should inform your doctor immediately. If you believe you’re having a medical emergency, call 911 right away. Severe side effects from Colchicine are not standard.

Severe side effects from Colchicine can include the following:

  • Muscle pain/weakness
  • Rapid heartbeat
  • Kidney problems
  • Fever
  • Strange bleeding/bruising
  • Numb or tingling fingers/toes

Drug Interactions with Colchicine

Before you begin to take Colchicine, you should tell your doctor about any herbs, vitamins, supplements, or medications that you’re taking or planning to begin taking.

Colchicine may interact with other prescription drugs. You tell your doctor if you’re taking the following prescription drugs as they may interact with Colchicine:

Strengths and Dosages of Colchicine

Colchicine is available in a 0.6 mg dose. Actual prescription doses from doctors may be different depending on the medical condition of each person.

This prescription drug should be taken by mouth with full cups of water. To further reduce the likelihood of kidney stones, you should consume at least eight to ten glasses of water each day while taking Colchicine.

Colchicine should not be taken in greater amounts than prescribed. This can lead to extreme side effects. You should not crush, break, chew, or split Colchicine as this may negatively impact its effectiveness.

If you miss a dose of Colchicine, take it as soon as you can. You should keep taking Colchicine even if you have gout episodes in the initial few weeks. If you think you’re having life-threatening health problems, alert 911 right away.


The following alternatives to Colchicine are available:

  • Colcrys
  • Indomethacin

FAQs of Colchicine?

What is Colchicine?

Colchicine is an anti-gout agent and prescription medication that is used to prevent or treat gout episodes.

How does Colchicine work?

This medication works by lowering excess uric acid crystals in the joints and reducing swelling.

What foods should you avoid when taking Colchicine?

You should avoid grapefruit and grapefruit juice while taking Colchicine.

Can I drink alcohol while taking Colchicine?

You can drink alcohol while taking Colchicine, but it may increase your blood’s uric acid levels.

How long does it take for Colchicine to work?

Colchicine is known to start working within 30 minutes to two hours.

How long does Colchicine stay in your system?

Colchicine can stay in your system for as long as ten days.

How long do you take Colchicine for gout?

Your doctor may prescribe Colchicine for as long as three to six months.

What is the biggest side effect of Colchicine?

Kidney problems are the biggest side effect of Colchicine. You should seek medical attention if you develop kidney problems from taking Colchicine.

How much Colchicine can I take in a day?

Your doctor will generally not prescribe more than 1.2 mg of Colchicine to take in one day

Can Colchicine cause diarrhea?

Diarrhea is a known side effect of Colchicine.

Can Colchicine be used for pericarditis?

Colchicine can be used for pericarditis.

What is the cost of Colchicine In America?

A 30-tablet, 0.6 mg supply of Colchicine is available for about $179 at most pharmacies across the United States.

Why does Colchicine cost so much?

Colchicine’s cost is due to its availability as a brand-name drug called Colcrys. There is also a generic version of Cochichine.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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